Vitamin D-ascorbic Acid Association in Bone Metabolism

  • P. A. Thornton


Previous results (Thornton and Brownrigg, 1961) have indicated that ascorbic acid influenced the skeletal response of chicks to vitamin D3 deficiency. Turnover of skeletal 45Ca was enhanced in vitamin D3 deficient individuals in the presence of ascorbic acid, suggesting a change in the bone metabolic rate. No specific role for vitamin D in bone cells has been evolved; however, investigations with cartilage have suggested a metabolic function in that tissue. It appears to be needed for normal formation and metabolism of citric acid (Neuman and Neuman, 1958).


Ascorbic Acid Deficient Group Phosphate Release Calcium Utilization Phosphate Mobilization 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1966

Authors and Affiliations

  • P. A. Thornton
    • 1
    • 2
  1. 1.Veterans Administration HospitalLexingtonUSA
  2. 2.Departments of Physiology and Biophysics and MedicineUniversity of KentuckyLexingtonUSA

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