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Vitamin D-ascorbic Acid Association in Bone Metabolism

  • P. A. Thornton

Abstract

Previous results (Thornton and Brownrigg, 1961) have indicated that ascorbic acid influenced the skeletal response of chicks to vitamin D3 deficiency. Turnover of skeletal 45Ca was enhanced in vitamin D3 deficient individuals in the presence of ascorbic acid, suggesting a change in the bone metabolic rate. No specific role for vitamin D in bone cells has been evolved; however, investigations with cartilage have suggested a metabolic function in that tissue. It appears to be needed for normal formation and metabolism of citric acid (Neuman and Neuman, 1958).

Keywords

Ascorbic Acid Deficient Group Phosphate Release Calcium Utilization Phosphate Mobilization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Barker, S. B., and W. H. Summerson. The colorimetric determination of lactic acid in biological material. J. biol. Chem. 138, 535 (1941).Google Scholar
  2. Borle, A. B., N. Nichols, and G. Nichols, Jr.. Metabolic studies of bone in vitro. I. Normal bone. J. biol. Chem. 235, 1206 (1960).PubMedGoogle Scholar
  3. Cohn, D. V., and B. K. Forscher. Aerobic metabolism of glucose by bone. J. biol. Chem. 237, 615 (1962).PubMedGoogle Scholar
  4. Fiske, C. H., and Y. Subbarow. The colorimetric determination of phosphorus. J. biol. Chem. 66, 375 (1925).Google Scholar
  5. Goldhaber, P.: Some factors affecting bone resorption in tissue culture. J. Bone Jt Surg. 43 B, 180 (1961).Google Scholar
  6. Gould, B. S., and H. Schwachman. Bone and tissue phosphatase in experimental scurvy and studies on the source of serum phosphatase. Amer. J. Physiol. 135, 485 (1941).Google Scholar
  7. Huggett, A. S. C., and D. A. Nixon. Use of glucose oxidase, peroxidase and O-dianisdine in determination of blood and urinary glucose. Lancet, 273, 368 (1957).PubMedCrossRefGoogle Scholar
  8. Levy, B. M., and R. V. GorlinThe temporomandibular joint in vitamin C deficiency. J. dent. Res. 32, 622 (1953).PubMedCrossRefGoogle Scholar
  9. Lilienthal, J. L., Jr.K. L. Zierler, B. P. Folk, R. Buka, and M. J. RileyA reference base and system for analysis of muscle constituents. J. biol. Chem. 182, 501 (1950).Google Scholar
  10. Neuman, W. F., and M. W. Neuman. The Chemical Dynamics of Bone. Chicago: The Uni versity of Chicago Press 1958.Google Scholar
  11. Thornton, P. A.: Unpublished.Google Scholar
  12. Thornton, P. A., and D. Brownrigg. Calcium utilization and skeletal development in chicks as influenced by parental dietary ascorbic acid. J. Nutr. 75, 354 (1961).PubMedGoogle Scholar
  13. Thornton, P. A., C. W. Weber, and R. E. Moreng. The effect of ascorbic acid in the diet of adult chickens on calcium utilization by the progeny. J. Nutr. 69, 33 (1959).PubMedGoogle Scholar
  14. Walker, D. G.: Citric acid cycle in osteoblasts and osteoclasts. Bull. Johns Hopk. Hosp. 106, 80 (1961).Google Scholar
  15. Willis, J. B.: Determinations of calcium and magnesium in urine by atomic absorption spectroscopy. Analyt. Chem. 33, 556 (1961).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1966

Authors and Affiliations

  • P. A. Thornton
    • 1
    • 2
  1. 1.Veterans Administration HospitalLexingtonUSA
  2. 2.Departments of Physiology and Biophysics and MedicineUniversity of KentuckyLexingtonUSA

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