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Immunodiagnosis in Schistosomiasis

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Bilharziasis

Abstract

Approximately 150 million people throughout the world are estimated to be presently infected with schistosomes. Although it is known that human infection with this trematode constitutes an important clinical and public health problem in Asia, Africa and South America and, to a lesser extent in the West Indies, reasonably accurate data on the prevalence and intensity of this infection are not often available. In many instances we do not even know whether the incidence of schistosomiasis in a given population group is increasing or decreasing and whether the areas affected are expanding or contracting. This lack of essential knowledge is largely due to the fact that an unequivocal diagnosis of schistosomiasis is difficult to obtain.

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References

  1. Anderson, R. I.: Current and potential value of immunodiagnostic tests employing a whole organism. Amer. J. Hyg. Monogr. Ser. 22, 97–109 (1963).

    Google Scholar 

  2. Anderson, R. I.: Relationship of antibody nitrogen to titer obtained in the cercarial antigen slide flocculation test for schistosomiasis. Exp. Parasit. 12, 434–440 (1962).

    Article  PubMed  CAS  Google Scholar 

  3. Anderson, R. I.: Serologic diagnosis of Schistosoma mansoni infections. I. Development of a cercarial antigen slide flocculation test. Amer. J. Trop. Med. Hyg. 9, 299–303 (1960).

    CAS  Google Scholar 

  4. Anderson, R. I., E. H. Sadun, and M. J. Scioenbechler: Cross absorption studies performed with Schistosoma mansoni and Trichinella spiralis antigens in sera from patients with trichinosis. Exp. Parasit. 14, 323–329 (1963).

    Article  PubMed  CAS  Google Scholar 

  5. Anderson, R. I., E. H. Sadun, and M. J. Scioenbechler: Some recent advances in the diagnosis of schistosomiasis. Med. Ann. D. C. 31, 211–215 (1962).

    CAS  Google Scholar 

  6. Anderson, R. I., E. H. Sadun, M. J. Scioenbechler, J. S. Williams: Preserved cercariae in the fluorescent antibody (FA) test for schistosomiasis. Exp. Parasit. 11, 226–230 (1961).

    Article  PubMed  CAS  Google Scholar 

  7. Anderson, R. I., E. H. Sadun, M. J. Scioenbechler, J. S. Williams: A technique for the use of minute amounts of dried blood in the fluorescent antibody test for schistosomiasis. Exp. Parasit. 11, 111–116 (1961).

    Article  PubMed  CAS  Google Scholar 

  8. D. H. Naimark: Serologic diagnosis of Schistosoma mansoni infections. II. Sensitivity of intradermal and serologic tests on individuals with an unequivocal diagnosis of schistosomiasis. Amer. J. Trop. Med. Hyg. 9, 600–603 (1960).

    Google Scholar 

  9. Biguet, J., A. Capron, P. Tran: Les antigenes de Schistosoma mansoni. I. Etude electrophoretique et immunoelectrophoretique. Caracterisation des antigenes specifiques. Ann. Inst. Pasteur. 103, 763–777 (1962).

    CAS  Google Scholar 

  10. Brandt, J. L., and E. P. Finch: A simple flocculation slide test for the diagnosis of schistosomiasis. Amer. J. Clin. Path. 16, 141–152 (1946).

    Google Scholar 

  11. Brewer, J. H., and A. Harris: Presented at Meeting of Maryland Branch. Amer. Soc. Microbiol., 1962.

    Google Scholar 

  12. Buck, A. A., E. H. Sadun, R. I. Anderson, and E. Shaffa: Comparative studies of some immunologic screening tests for schistosomiasis in Ethiopia. Amer. J. Hyg. 80, 75–84 (1964).

    PubMed  CAS  Google Scholar 

  13. Chaffee, E. F., P. M. Bauman, and J. J. Shapilo: Diagnosis of schistosomiasis by complement-fixation. Amer. J. Trop. Med. Hyg. 3, 905–913 (1954).

    CAS  Google Scholar 

  14. Clarke, V.: Personal communication, 1963.

    Google Scholar 

  15. Desowitz, R. S.: Effect of antibody on the respiratory rate of Trypanosoma vivax. Nature 177, 132–133 (1956).

    Article  PubMed  CAS  Google Scholar 

  16. Eliakim, M., and A. M. Davies: The complement-fixation test in bilharziasis. II. Preparation and preservation of antigens from Schistosoma mansoni worms extracted in Coca’s solution. Parasitology 45, 189–194 (1955).

    Article  PubMed  CAS  Google Scholar 

  17. Fife, E. H., K. A. Sleeman, and J. I. Bruce: Studies on the exoantigens of Schistosoma mansoni cercariae. (In Press).

    Google Scholar 

  18. Foster, R.: Skin antigen tests and the fluorescent antibody technique in the diagnosis of schistosomiasis. (In Press).

    Google Scholar 

  19. Jachowsxr, L. A., and R. I. Anderson: Evaluation of some laboratory procedures in diagnosing infections with Schistosoma mansoni. Bull. Wld Hlth Org. 25, 675–693 (1961).

    Google Scholar 

  20. E. H. Sadun: Serologic reactions to Schistosoma mansoni. I. Quantitative studies on experimentally infected monkeys (Macaca mulatta). Amer. J. Hyg. 77, 137–145 (1963).

    Google Scholar 

  21. Kagan, I. G.: Personal communication, 1963.

    Google Scholar 

  22. L. Norman: Analysis of helminth antigens (Echinococcus granulosus and Schistosoma mansoni) by agar gel methods. Ann. N. Y. Acad. Sci. 113, 130–153 (1963).

    PubMed  Google Scholar 

  23. J. Pellegrino, and J. M. P. Memoria: Studies on the standardization of the intradermal test for the diagnosis of bilharziasis. Amer. J. Trop. Med. Hyg. 10, 200–207 (1961).

    Google Scholar 

  24. J. Pellegrino, and J. M. P. Memoria: A critical review of immunological methods for the diagnosis of bilharziasis. Bull. Wld Hlth Org. 25, 611–674 (1961).

    Google Scholar 

  25. J. Pellegrino, and J. M. P. Memoria: Hemagglutination after immunization with schistosome antigens. Science. 122, 376–377 (1955).

    Article  Google Scholar 

  26. Kent, J. F.: Current and potential value of immunodiagnostic tests employing soluble antigens. Amer. J. Hyg. Monogr. Ser. 22, 68–90 (1963).

    Google Scholar 

  27. E. H. Fife, Jr.: Precise standardization of reagents for complement fixation. Amer. J. Trop. Med. Hyg. 12, 103–116 (1963).

    Google Scholar 

  28. Kent, N. H.: Comparative immunochemistry of larval and adult forms of Schistosoma mansoni. Ann. N. Y. Acad. Sci. 113, 100–113 (1963).

    Article  PubMed  CAS  Google Scholar 

  29. Lewert, R. M.: Personal communication, 1963.

    Google Scholar 

  30. Liu, C., and F. B. Bang: Agglutination of cercariae of Schistosoma mansoni by immune sera. Proc. Soc. Exp. Biol. 74, 68–72 (1950).

    Google Scholar 

  31. Newsome, J.: Investigation of anti-schistosome opsonins in vivo.Trans. Roy. Soc. I roi). Med. Hyg. 58, 58–62 (1964).

    Article  CAS  Google Scholar 

  32. Okabe, K., and T. Tanaka: A new urine precipitin reaction for schistosomiasis japonica. Kurume Med. J. 5, 45–52 (1958).

    Article  Google Scholar 

  33. Y. Koga, H. Shibue, and M. Matsuse: Immunological studies on schistosomiasis Japonica. 3. Intradermal and precipitin tests for schistosomiasis japonica. Kurume Med. J. 1, 85–89 (1954).

    Google Scholar 

  34. Oliver-Gonzalez, J.: Anti-egg precipitin in the serum of humans infected with Schistosoma mansoni. J. Infect. Dis. 95, 86–91 (1954).

    Article  PubMed  CAS  Google Scholar 

  35. C. K. Pratt: Skin and precipitin reactions to antigens from the cercariae and adults of Schistosoma mansoni. Puerto Rico J. Publ. Hlth 20, 242–256 (1944).

    Google Scholar 

  36. Pautrizel, R.: Personal communication, 1963.

    Google Scholar 

  37. Pellegrino, J.: The intradermal test in the diagnosis of bilharziasis. Bull. Wld Hlth Org. 18, 945–961 (1958).

    CAS  Google Scholar 

  38. Pellegrino, J.: Immunological methods for the diagnosis of schistosomiasis mansoni. In: Procedings Seventh Internat. Cong. Trop. Med. Malaria, Rio de Janeiro, 1, 21–23 (1963).

    Google Scholar 

  39. E. Paulini, J. M. P. Memoria, and D. G. Macedo: A reacao intradermica na esquistossomose corn una fracao polissacaridea isolada de cercarias de Schistosoma mansoni. Malar. Doen. Trop. 8, 527–534 (1956).

    Google Scholar 

  40. Portnoy, J., J. H. Brewer, and A. Harris: Rapid plasma reagin card test for syphilis and other treponematoses. Publ. Hlth Rep. 77, 645–652 (1962).

    Article  CAS  Google Scholar 

  41. Rieber, S., R. I. Anderson, and M. G. Radke: Serologic diagnosis of Schistosoma mansoni infections. III. Isolation and purification of antigen from adult S. mansoni for the complement fixation test. Amer. J. Trop. Med. Hyg. 10, 351–355 (1961).

    CAS  Google Scholar 

  42. Sadun, E. H.: Trichinosis, hydatid disease, schistosomiasis and ascariasis. In: Immunological diseases. Sampter, W., and H. L. Alexander (Eds.). Boston: Little Brown and Co. 1965.

    Google Scholar 

  43. Sadun, E. H.: Recent advances in the diagnosis of the most prevalent human trematode infections in Asia. Abstracts of the Ninth Pacific Congress, Bangkok, Thailand, 1957.

    Google Scholar 

  44. M. J. Schoenbechler, and M. Bentz: Multiple antibody response in schistosoma mansoni infections. Amer. J. Trop. Med. Hyg. 14, 977–995 (1965).

    Google Scholar 

  45. R. I. Anderson, and M. J. Schoenbeculer: A plasma card test for rapid serodiagnosis of schistosomiasis (SPC). Proc. Soc. Exp. Biol. 112, 280–283 (1963).

    PubMed  Google Scholar 

  46. E. Biocca: Intradermal and fluorescent antibody tests on humans exposed to Schistosoma bovis cercariae from Sardinia. Bull. Wld Hlth Org. 27, 810–814 (1962).

    Google Scholar 

  47. R. I. Anderson, and J. S. Williams: Fluorescent antibody test for the laboratory diagnosis of schistosomiasis in humans by using dried blood smears on filter paper. Exp. Parasit. 11, 117–120 (1961).

    Article  PubMed  Google Scholar 

  48. J. S. Williams, and R. I. Anderson: Fluorescent antibody technic for serodiagnosis of schistosomiasis in humans. Proc. Soc. Exp. Biol. 105, 289–291 (1960).

    PubMed  Google Scholar 

  49. S. S. Lin, and B. C. Walton: Studies on the host parasite relationships to Schistosoma japonicum: III. The use of purified antigens in the diagnosis of infections in human and experimental animals. Milit. Med. 124, 428–436 (1959).

    Google Scholar 

  50. A. A. Buck, and B. C. Walton: The use of purified antigens in the immunodiagnosis of paragonimiasis in humans and experimental animals. J. Parasit. 44 (Suppl.) (1958).

    Google Scholar 

  51. Schneider, M. D., and M. G. Radke: Further observations on a complement fixing substance from Schistosoma mansoni. Proc. Med. Soc. (Washington) 24, 137–139 (1957).

    CAS  Google Scholar 

  52. M. T. Coleman: Immunologically reactive substance from Schistosoma mansoni. Exp. Parasit. 4, 391–397 (1956).

    Google Scholar 

  53. Senterfit, L. B.: Immobilization of Schistosoma mansoni miracidia by immune serum. Proc. Soc. Exp. Biol. 84, 5–7 (1953).

    PubMed  CAS  Google Scholar 

  54. Sherif, A. F.: Schistosomal metabolic products in the diagnosis of bilharziasis. Ciba Fundation Symposium Bilharziasis, Wolstenholme, G. E. W., and O’Connor, M. (Eds.). Boston: Little Brown and Co. 1962.

    Google Scholar 

  55. Sleeman, H. K.: Isolation and study of a specific complement fixing antigen from adult Schistosoma mansoni. Amer. J. Trop. Med. Hyg. 9, 11–17 (1960).

    CAS  Google Scholar 

  56. E. H. Fife, and J. I. Bruce: Isolation and characterization of serologically active components from secretory and excretory products of Schistosoma mansoni cercariae. J. Parasit. 19, 36 (1963).

    Google Scholar 

  57. J. D. Burke, and J. F. Kent: Physicochemical and serologic studies of Schistosoma mansoni antigens. Amer. J. Trop. Med. Hyg. 7, 241 (1958).

    Google Scholar 

  58. Smithers, R. S.: Gel-diffusion studies on Schistosoma mansoni. Trans. Roy. Soc. Trop. Med. Hyg. 54, 8 (1960).

    Article  Google Scholar 

  59. Taliaferro, W. H., W. A. Hoffman, and D. H. Cook: A precipitin test in intestinal schistosomiasis (S. mansoni). J. Prey. Med. 2, 395–414 (1928).

    Google Scholar 

  60. Toussaint, A. S.: Improvement of the soluble antigen fluorescent antibody procedure. Exp. Parasit. (in press).

    Google Scholar 

  61. Toussaint, A. J., and R. I. Anderson: A soluble antigen fluorescent antibody (SAFA) technic. Appl. Microbiol. 13, 552–558 (1965).

    PubMed  CAS  Google Scholar 

  62. Vogel, H., U. W. Minning: Hüllenbildung bei Bilharzia-Cercariaen im Serum Bilharzia-infizierter Tiere und Menschen. Zbl. Bakt. 153, 91–105 (1940).

    Google Scholar 

  63. Wright, W. H., J. Bozicevich, F. J. Brady, and P. M. Bauman: The diagnosis of Schistosomiasis japonica. V. The diagnosis of Schistosomiasis japonica by means of serological tests. Amer. J. Hyg. 45, 150–163 (1947).

    CAS  Google Scholar 

  64. Yoshimoto, M.: Ûber die Komplement-Bindungsreaktion bei der Schistosomum-Krankheit in Japan. Z. Immun.-Forsch. 5, 438–445 (1910).

    Google Scholar 

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Sadun, E.H. (1967). Immunodiagnosis in Schistosomiasis. In: Mostofi, F.K. (eds) Bilharziasis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49777-3_26

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  • DOI: https://doi.org/10.1007/978-3-642-49777-3_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49492-5

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