Effect of Some Metabolic Factors and Drugs on Uptake and Release of Catecholaminess in vitro and in vivo

  • U. S. von Euler
Part of the Bayer Symposium book series (BAYER-SYMP, volume 2)


Since the demonstration of ATP in relatively large amounts in adrenal medullary granules (Htllarp, Högberg and Nilson, 1955) and in nerve granules (Schtmann, 1958) this nucleotide has been implicated in the amine storage function of these organelles.


Adrenal Medulla Metabolic Factor Adrenergic Nerve Axon Membrane Sympathomimetic Amine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Armett, C. J., Rrreame, J. M.: The action of acetylcholine on conduction in mammalian nonmyelinated fibres and its prevention by an anticholinesterase. J. Physiol. (Lond.) 152, 141–158 (1960).Google Scholar
  2. Axelrod, J., Herttino, G., Potter, L.: Effect of drugs on the uptake and release of 311-norepinephrine in the rat heart. Nature (Lond.) 194, 297 (1962).CrossRefGoogle Scholar
  3. Bell, C.: Fine structural localization of acetylcholinesterase at a cholinergie vasodilator nerve-arterial smooth muscle synapse. Circulat. Res. 24, 61–70 (1969).PubMedCrossRefGoogle Scholar
  4. Belleau, B.: Relationships between agonists, antagonists and receptor sites. Ciba Foundation Symposium “Adrenergic Mechanisms”, p. 223–245. London: J. & A. Churchill Ltd. 1960.Google Scholar
  5. Belleau, B., Martel, R., Lacasse, G., Menard, M., Weinberg, N. L., Perron, Y. G.: N-Carboxylic acid esters of 1,2- and 1,4-dihydroquinolines. A new class of irreversible inactivators of the Catecholamines a receptors and potent central nervous system depressants. J. Amer. Chem. Soc. 90, 823 (1968).CrossRefGoogle Scholar
  6. Butraingham, A. T., Wilson, A. B.: Preganglionic and postganglionic stimulation of the guinea-pig isolated vas deferens preparation. Brit. J. Pharmacol. 21, 569–580 (1963).Google Scholar
  7. Burgen, A. S. V., Iversen, L. L.: The inhibition of noradrenaline uptake by sympathomimetic amines in the rat isolated heart. Brit. J. Pharmacol. 25, 34–49 (1965).PubMedGoogle Scholar
  8. Burger, A., Pruire U. A., Schumann, H. J.: Untersuchungen zur Bedeutung einer ATPase aus Milznervengranula. Naunyn Schmiedebergs Arch. Pharmak. exp. Path. 260, 101–102 (1968).Google Scholar
  9. Burn, J. H.: Introductory remarks. In: Adrenergic transmission, Sec. V. Pharmacol. Rev. 18, 459–470 (1966).Google Scholar
  10. Burn, J. H., Rand, M. J.: The action of sympathomimetic amines in animals treated with reserpine. J. Physiol. (Lond.) 144, 314–336 (1958).Google Scholar
  11. Burn, J. H., Rand, M. J.: Sympathetic postganglionic mechanism. Nature (Lond.) 184, 163–165 (1959).CrossRefGoogle Scholar
  12. Burnstocr, G., Holman, M. E.: Smooth muscle: Autonomic nerve transmission. Ann Rev. Physiol. 25, 61–85 (1963).CrossRefGoogle Scholar
  13. Burnstocr, G., Rosnvson, P. M.: Localization of Catecholaminess and acetylcholinesterase in autonomic nerves. Circulat. Res. 21, Suppl. III, 43–55 (1967).Google Scholar
  14. Bygdeman, S., Johnsen, O.: Studies on the effect of adrenergic blocking drugs on Catecholamines-induced platelet aggregation and uptake of noradrenaline and 5-hydroxytryptamine. Acta physiol. stand. 75, 129–138 (1969).CrossRefGoogle Scholar
  15. Carlsson, A., Hillarp, N.-A., Waldeck, B.: A Mg++-ATP dependent storage mechanism in the amine granules of the adrenal medulla. Med. exp. 6, 47–53 (1962).PubMedGoogle Scholar
  16. Carlsson, A., Hillarp, N -A., Waldeok, B.: Analysis oftheMg++ATP dependent storage mechanism in the amine granules of the adrenal medulla. Acta physiol. stand. 59, Suppl. 215 (1963).Google Scholar
  17. Davies, B. N., Horton, E. W., Witmunoton, P. G.: The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation. J. Physiol. (Lond.) 188, 38P–39P (1967).Google Scholar
  18. Day, M. D., Owen, D. A. A.: The interaction between angiotensin and sympathetic vasoconstriction in the isolated artery of the rabbit ear. Brit. J. Pharmacol. 34, 499–507 (1968).CrossRefGoogle Scholar
  19. Diorio, A.: The release of Catecholaminess from the isolated chromaffine granules of the adrenal medulla using sulphydryl inhibitors. Canad. J. Biochem. 35, 395–400 (1957).CrossRefGoogle Scholar
  20. Euler, U. S.: Sympathin, histamine and acetylcholine in mammalian nerves. J. Physiol. (Loud.) 107, 10P–11P (1948).Google Scholar
  21. Euler, U. S.: Acute neuromuscular transmission failure in vas deferens after reserpine. Acta physiol. scand. 76, 255–256 (1969).CrossRefGoogle Scholar
  22. Euler, U. S., Hedqvist, P.: Inhibitory action of prostaglandins E1 and E2 on the neuromuscular transmission in the guinea pig vas deferens. Acta physiol. scand. 77, 510–512 (1969).CrossRefGoogle Scholar
  23. Euler, U. S., Lishajko, F.: Effect of reserpine on the release of noradrenaline from transmitter granules in adrenergic nerves. Science 132, 351–352 (1960).CrossRefGoogle Scholar
  24. Euler, U. S., Lishajko, F.: Effect of reserpine on the release of Catecholaminess from isolated nerve and chromaffin cell granules. Acta physiol. scand. 52, 137–145 (1961).CrossRefGoogle Scholar
  25. Euler, U. S., Lishajko, F.: Effect of adenine nucleotides on Catecholamines release and uptake in isolated adrenergic nerve granules. Acta physiol. scand. 59, 454–461 (1963).CrossRefGoogle Scholar
  26. Euler, U. S., Lishajko, F.: Effect of reserpine on the uptake of Catecholaminess in isolated nerve storage granules. Int. J. Neuropharmacol. 2, 127–134 (1963).CrossRefGoogle Scholar
  27. Euler, U. S., Lishajko, F.: Effect of drugs on the storage granules of adrenergic nerves. In: Pharmacology of cholinergic and adrenergic transmission, Proc. 2nd Internat. Pharmacol. Meeting, Prague, 1963, pp. 245–259, Praha: Czechoslovak Medical Press 1965.Google Scholar
  28. Euler, U. S., Lishajko, F.: Effect of directly and indirectly acting sympathomimetic amines on adrenergic transmitter granules. Acta physiol. scand. 73, 78–92 (1968).CrossRefGoogle Scholar
  29. Euler, U. S., Lishajko, F.: Inhibitory action of adrenergic blocking agents on reuptake and net uptake of noradrenaline in nerve granules. Acta physiol. scand. 74, 501–506 (1968).CrossRefGoogle Scholar
  30. Euler, U. S., Lishajko, F.: Observations on the actions of prenylamine (Segontin) in vivo and on adrenergic transmitter granules. Biochim. appl. (Parma) 14, Suppl. I, 17–32 (1968).Google Scholar
  31. Euler, U. S., Lishajko, F.: Effects of some metabolic co-factors and inhibitors on transmitter release and uptake in isolated adrenergic nerve granules. Acta physiol. scand. 77, 298–307 (1969).CrossRefGoogle Scholar
  32. Euler, U. S., Persson N.-A.: Potentiationofadrenergic cardiovascular effects of two quaternary nicotine analogues by reserpine. Acta physiol. scand. 78, 459–464 (1970).CrossRefGoogle Scholar
  33. Ferry, C. B.: The sympathomimetic effect of acetylcholine on the spleen of the cat. J. Physiol. (Loud.) 167, 487–504 (1963).Google Scholar
  34. Foluow, B., Häggendal, J., Lisander, B.: Extent of release and elimination of noradrenaline at peripheral adrenergic nerve terminals. Acta physiol. scand. 72, Suppl. 307 (1968).Google Scholar
  35. Hedqvist, P.: On the mechanism of depletion of noradrenaline stores by iso-monomethyl-nicotinium bromide. Acta physiol. scand. 78, 117–122 (1970).PubMedCrossRefGoogle Scholar
  36. Hedqvist, P.: Modulating effect of prostaglandin E2 on noradrenaline release from the isolated cat spleen. Acta physiol. scand. 75, 511–512 (1969).PubMedCrossRefGoogle Scholar
  37. Hedqvist, P.: Antagonism between prostaglandin E2 and phenoxyhenzamine on noradrenaline release from the cat spleen. Acta physiol. scand. 76, 383–384 (1969).PubMedCrossRefGoogle Scholar
  38. Hedqvist, P., Brundin, J.: Inhibition of prostaglandin E1 of noradrenaline release and of effector response to nerve stimulation in the cat spleen. Life Sci. 8, 389–395 (1969).PubMedCrossRefGoogle Scholar
  39. Hrllarp, N.-A.: Enzymic systems involving adenosinephosphates in the adrenaline and nor-adrenaline containing granules of the adrenal medulla. Acta physiol. scand. 42, 141–165 (1958).Google Scholar
  40. Hrllarp, N.-A.: Some problems concerning the storage of catechol amines in the adrenal medulla. Ciba Foundation Symposium “Adrenergic Mechanisms”, p. 481–501. London: J. & A. Churchill Ltd. 1960.Google Scholar
  41. Hrllarp, N.-A., Högberg, B., Nilson, B.: Adenosine triphosphate in the adrenal medulla of the cow. Nature (Lond.) 176, 1032–1033 (1955).CrossRefGoogle Scholar
  42. Hugovic, S.: Responses of the isolated sympathetic nerve ductus deferens preparation of the guinea-pig. Brit. J. Pharmacol. 16, 188–194 (1961).Google Scholar
  43. Iversen, L. L.: The uptake of noradrenaline by the isolated perfused rat heart. Brit. J. Pharmacol. 21, 523–537 (1963).PubMedGoogle Scholar
  44. Jonasson, J., Rosengren, E., Waldeck, B.: Effects of some pharmacologically active amines on the uptake of arylalkylamines by adrenal medullary granules. Acta physiol. scand. 60, 136–140 (1964).PubMedCrossRefGoogle Scholar
  45. Katz, B.: The release of neural transmitter substances. The Sherrington Lectures Y. Liverpool: Univ. Press 1969.Google Scholar
  46. Kirshner, N.: Uptake of Catecholaminess by a particulate fraction of the adrenal medulla. J. biol. Chem. 237, 2311–2317 (1962).PubMedGoogle Scholar
  47. Lindmar, R., Löffelholz, K., Muscholl, E.: A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents. Brit. J. Pharmacol. 32, 280–294 (1968).PubMedGoogle Scholar
  48. Lindmar, R., Muscholl, E:: Die Wirkung von Pharmaka auf die Elimination von Noradrenalin aus der Perfusionsflüssigkeit und die Noradrenalinaufnahme in das isolierte Herz. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak 247, 469–492 (1964).Google Scholar
  49. Lishajko, F.: Release, reuptake and net uptake of dopamine, noradrenaline and adrenaline in isolated sheep adrenal medullary granules. Acta physiol. scand. 76, 159–171 (1969).PubMedCrossRefGoogle Scholar
  50. Malik, K. U., Ling, G. M.: Modification by acetylcholine of the response of rat mesenteric arteries to sympathetic stimulation. Circulat. Rea. 25, 1–9 (1969).CrossRefGoogle Scholar
  51. Mantegazza, P., Naimzada, M. K.: Attivita della prostaglandina El sul preparato nervo ipogastrico-deferente di varie specie animali. Atti Accad. med. lombarda 20, 58–64 (1965).Google Scholar
  52. Nachmanso N. D.: Role of acetylcholine in neuromuscular transmission. Ann. N. Y. Acad. Sci. 135, 136–149 (1966).CrossRefGoogle Scholar
  53. Nasmyth, P. A.: An investigation of the action of tyramine and its interrelationship with the effects of other sympathomimetic amines. Brit. J. Pharmacol. 18, 65–75 (1962).PubMedGoogle Scholar
  54. Owman, C., Sjöstrand, N. O.: On short adrenergic neurons in the accessory male genital organs of the bull. Experientia (Basel) 22, 759–761 (1966).CrossRefGoogle Scholar
  55. Pfenninger, K., Sandri, C., Akert, K., Eugster, C. H.: Contribution to the problem of structural organization of the presynaptie area. Brain Res. 12, 10–18 (1969).PubMedCrossRefGoogle Scholar
  56. Schümann, H. J.: Über den Noradrenalin-und ATP-Gehalt sympathischer Nerven. NaunynSchmiedebergs Arch. exp. Path. Pharmak. 233, 296–300 (1958).Google Scholar
  57. Schümann, H. J., Prmrepu, A.: The mechanism of Catecholamines release by tyramine. Int. J. Neuropharmacol. 1, 179–182 (1962).CrossRefGoogle Scholar
  58. Sjöstrand, N. O.: Effect of some smooth muscle stimulants on the motor response of the isolated guinea pig vas deferens to hypogastric nerve stimulation. Nature (Lond.) 192, 1190–1191 (1961).CrossRefGoogle Scholar
  59. Smith, A. D.: Biochemistry of adrenal chromaffin granules. In: The interaction of drugs and subcellular components in animal cells, ( Campbell, P. N., Ed.) London: J. A. Churchill Ltd. 1968.Google Scholar
  60. Stjïrne, L.: Studies of Catecholamines uptake storage and release mechanisms. Acta physiol. scand. 62, 228 (1964).Google Scholar
  61. Sutherland, E. W., Robison, G. A., Butcher, R. W.: Some aspects of the biological role of adenosine 3’,5’-monophosphate (cyclic AMP) Circulation 37, 279–306 (1968).Google Scholar
  62. Taugner, G., Hasselbach, W.: Über den Mechanismus der Catecholamin-Speicherung in den „chromaffinen Granula“ des Nebennierenmarks. Naunyn-Schmiedebergs Arch. Pharmak exp. Path. 255, 266–286 (1966).Google Scholar
  63. Trendelenburg, U.: Modification of the effect of tyramine by various agents and procedures. J. Pharmacol. exp. Ther. 134, 8–17 (1961).PubMedGoogle Scholar
  64. Wilcken, D. E. L., Brender, D., Shorey, C. D., Macdonald, G. J.: Reserpine: Effect on structure of heart muscle. Science 157, 1332–1334 (1967).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1970

Authors and Affiliations

  • U. S. von Euler
    • 1
  1. 1.Department of Physiology Faculty of MedicineKarolinska InstituteStockholmSweden

Personalised recommendations