Skip to main content
Book cover

Current Problems in Immunology pp 47–62Cite as

Mammalian Erythrocyte Receptors: Their Nature and their Significance in Immunopathology

  • Chapter

Part of the Bayer-Symposium book series (BAYER-SYMP,volume 1)

Abstract

Immunity reactions are interactions between the host and his environment. In this interaction “receptors” in the sense of Paul Ehrlich (1901) play a paramount role. The study of immunity reactions is not only important in itself but it furthers comprehension of other host-environment interactions including those of toxins, drugs or even live agents such as viruses. In all instances the agent or its products, be they noxious or beneficial, have first to attach to a receptor before they can begin to exert their influence.

Keywords

  • Influenza Virus
  • Sialic Acid
  • Blood Group
  • Infectious Mononucleosis
  • Sheep Erythrocyte

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This investigation has been supported by Atomic Energy Commission Contract No. At(11–1)1285, by National Institutes of Health Grant Nos. AI-05681 and AI-05682, by National Science Foundation Grant GB 8378, by The John A. Hartford Foundation Grant SD-340 and the Chicago Heart Association Grant RN 69–43.

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-49733-9_6
  • Chapter length: 16 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-49733-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   139.00
Price excludes VAT (USA)
Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adye, J. C., and G. F. Springer: Mode of inhibition of endotoxin coating of human red cells by compounds of known structure. Fed. Proc. 27, Nr. 2, 267 (1968).

    Google Scholar 

  • Anderson, B., P. Hoffman, and K. Meyer: The 0-serine linkage in peptides of chondrotin 4- or 6-sulfate. J. biol. Chem. 240, 156–167 (1965).

    PubMed  CAS  Google Scholar 

  • Baranowski, T., E. Lisowska, A. Morawiecki, E. Romanowska, and K. Strózecka: Studies on blood group antigens M and N; III. Chemical composition of purified antigens. Arch. Immunol. Terapii Dows. 7, 15–27 (1959).

    CAS  Google Scholar 

  • Beychok, S., and E. A. Kabat: Optical activity and conformation of carbohydrates. I. Optical rotatory dispersion studies on immunochemically reactive amino sugars and their glycosides, milk oligosaccharides of glucose, and blood group substances. Biochemistry 4, 2565–2574 (1965).

    PubMed  CrossRef  CAS  Google Scholar 

  • Bezkorovainy, A., G. F. Springer, and K. Hotta: Some physical properties of the human NN-and Me-Vg blood-group antigens. Biochim. biophys. Acta (Amst.) 115, 501–504 (1966).

    CrossRef  CAS  Google Scholar 

  • Callahan, H., and G. F. Springer: Infectious mononucleosis receptor from sheep erythrocytes. Fed. Proc. 25, Nr. 2, 435 (1966).

    Google Scholar 

  • Carsten, M. E., and E. A. Kabat: Immunochemical studies on blood groups. XIX. The amino acids of blood group substances. J. Amer. chem. Soc. 78, 3083–3087 (1956).

    CrossRef  CAS  Google Scholar 

  • Ehrlich, P.: Reprinted in P. Ehrlich: Gesammelte Arbeiten, Vol. 2, p. 316 ( 1901 ). Berlin-Göttingen-Heidelberg: Springer 1957.

    Google Scholar 

  • Gottschalk, A.: Glycoproteins, Vol. 5, pp. 434–438. Amsterdam, London, New York: Elsevier 1966.

    Google Scholar 

  • Henle, G., W. Henle, and V. Diehl: Relation of Burkitt’s tumor-association herpes-type virus to infectious mononucleosis. Proc. nat. Acad. Sci. (Wash.) 59, 94–101 (1968).

    CrossRef  CAS  Google Scholar 

  • Hotta, K., and G. F. Springer: Isolation and partial characterization of blood group N specific haptens from human blood group M and N substances. In: Proc. X. Congr. Int. Soc. Bl. Transf. Stockholm 1964, pp. 505–509. Basel-New York: Karger 1965.

    Google Scholar 

  • Jirgensons, B., and G. F. Springer: Conformation of blood-group and virus receptor glycoproteins from red cells and secretions. Science 162, 365–367 (1968).

    PubMed  CrossRef  CAS  Google Scholar 

  • Kabat, E. A.: Blood-group substances. New York: Academic Press, Inc. 1956.

    Google Scholar 

  • Kabat, E. A., E. W. Bassett, K. Pryzwansky, K. O. Lloyd, M. E. Kaplan, and E. J. Layug: Immunochemical studies on blood groups. XXXIII. The effects of alkaline borohydride and of alkali on blood group A, B, and H substances. Biochemistry 4, 1632–1638 (1965).

    PubMed  CrossRef  CAS  Google Scholar 

  • Kathan, R. H., R. J. Winzler, and C. A. Johnson: Preparation of an inhibitor of viral hemagglutination from human erythrocytes. J. exp. Med. 113, 37–45 (1961).

    PubMed  CrossRef  CAS  Google Scholar 

  • Klenk, E., u. G. Uhlenbruck: On the isolation of mucoids containing neuraminic acid from human erythrocyte stroma, a contribution to the chemistry of agglutinogens. Z. physiol. Chem. 319, 151–160 (1960).

    CrossRef  CAS  Google Scholar 

  • Kriipe, M., u. G. Uhlenbruck: Zur Natur der Phytagglutininrezeptoren an einigen Erythrozytenmucoiden von Mensch, Rind and Pferd. Z. Immun-Forsch. 126, 408–414 (1964).

    Google Scholar 

  • Landsteiner, K., and P. Levine: Inheritance of agglutinogens of human blood demonstrable by immune agglutinins. J. exp. Med. 48, 731–749 (1928).

    CAS  Google Scholar 

  • Luderitz, O., O. Westphal, K. Sievers, E. Kröger, E. Neter u. O. H. Braun: Über die Fixation von P32-markiertem Lipopolysaccharid (Endotoxin) aus Escherichia coli an menschlichen Erythrozyten. Biochem. Z. 330, 34–46 (1958).

    PubMed  CAS  Google Scholar 

  • Mäkelä, O., and K. Cantell: Destruction of MN blood group receptors of human red cells by some influenza viruses. Ann Med. exp. Fenn. 36, 366–374 (1958).

    Google Scholar 

  • Morawiecki, A.: Dissociation of M- and N-group mucoproteins into subunits in detergent solutions. Biochim. biophys. Acta (Amst) 83, 339–347 (1964).

    CAS  Google Scholar 

  • Neter, E.: Bacterial hemagglutination and hemolysis. Bact. Rev. 20, 166–188 (1956).

    PubMed  CAS  Google Scholar 

  • Niederman, J. C., R. W. McCollum, G. Henle, and W. Henle: infectious mononucleosis.Clinical manifestations in relation to EB virus antibodies. J. Amer. med. Ass. 203, 205–209 (1968).

    CrossRef  CAS  Google Scholar 

  • Paul, J. R., and W. W. Bunnell: The presence of heterophile antibodies in infectious mononucleosis. Amer. J. med. Sci. 183, 90–104 (1932).

    CrossRef  Google Scholar 

  • Pusztai, A., and W. T. J. Morgan: Studies in immunochemistry 22. The amino acid composition of the human blood-group A, B, H, and Lea specific substances. Biochem. J. 88, 546–555 (1963).

    PubMed  CAS  Google Scholar 

  • Springer, G. F.: Human MN glycoproteins: dependence of blood-group and anti-influenza virus activities on their molecular size. Biochem. biophys. Res. Commun. 28, 510–513 (1967).

    CAS  Google Scholar 

  • Springer, G. F., and N. J. Ansell: Inactivation of human erythrocyte agglutinogens M and N by influenza viruses and receptor-destroying enzyme. Proc. nat. Acad. Sci. (Wash.) 44, 182–189 (1958).

    CrossRef  CAS  Google Scholar 

  • Springer, G. F., M. A. Fletcher, and J. Gegersen : Amide content of erythrocyte blood-group and virus inhibitory glycoproteins. Fed. Proc. 28, Nr. 2, 899 (1969c).

    Google Scholar 

  • Springer, G. F., and R. E. Horton: Erythrocyte sensitization by blood group specific bacterial antigens. J. gen. Physiol 47, Nr. 6, 1229–1250 (1964).

    PubMed  CrossRef  CAS  Google Scholar 

  • Springer, G. F., and R. E. Horton: Blood-group isoantibody stimulation in man by feeding blood-group active bacteria. J. Clin. Invest. July, 1969.

    Google Scholar 

  • Springer, G. F., and R. E. Horton, and M. Forbes: Origin of anti-human blood group B agglutinins in white leghorn chicks. J. exp. Med. 110, Nr. 2, 221–244 (1959).

    PubMed  CrossRef  CAS  Google Scholar 

  • Springer, G. F., S. V. Huprikar, and E. Neter: Specific endotoxin neutralization by human erythrocyte receptor substance. Submitted for publication, 1969 d.

    Google Scholar 

  • Springer, G. F., Y. Nagai, and H. Tegtmeyer: Isolation and properties of human blood-group NN and Meconium-Vg antigens. Biochemistry 5, 3254–3272 (1966a).

    PubMed  CrossRef  CAS  Google Scholar 

  • Springer, G. F., W. Pollmann (1) and C. S. Wang: In preparation (1969 a).

    Google Scholar 

  • Springer, G. F., and M. J. Rapaport: Specific release of heterogenetic “mononucleosis receptor” by influenza viruses, receptor destroying enzyme and plant proteases. Proc. Soc. exp. Biol. (N. Y.) 96, 103–107 (1957).

    CAS  Google Scholar 

  • Springer, G. F., H. G. Schwick, and M. A. Fletcher: The relationship of the influenza virus inhibitory activity of glycoproteins to their molecular size and sialic acid content. Proc. nat. Acad. Sci. (Wash.) June, 1969 b.

    Google Scholar 

  • Springer, G. F., E. T. Wang, J. H. Nichols, and J. M. Shear: Relations between bacterial lipopolysaccharide structures and those of human cells. Ann N Y. Acad. Sci. 133 2, 566–579 (1966 b).

    CrossRef  Google Scholar 

  • Springer, G. F., P. Williamson, and W. C. Brandes: Blood group activity of gramnegative bacteria. J. exp. Med. 113, Nr. 6, 1077–1093 (1961).

    CrossRef  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunochemistry Research, Evanston Hospital, Northwestern University, 2650 Ridge Avenue, Evanston, Illinois, 60201, USA

    Prof. Dr. Georg F. Springer

Authors
  1. Prof. Dr. Georg F. Springer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Direktor, Max-Planck-Instituts für Immunbiologie, 7800, Freiburg-Zähringen, Deutschland

    Professor Dr. Otto Westphal

  2. Direktor der Medizinischen Klinik der Universität, 7400, Tübingen, Deutschland

    Professor Dr. Dr. h. c. Hans-Erhard Bock

  3. Vorstand des Instituts für experimentelle Pathologie, Farbenfabriken Bayer AG, 5600, Wuppertal-Elberfeld, Deutschland

    Professor Dr. Ekkehard Grundmann

Rights and permissions

Reprints and Permissions

Copyright information

© 1969 Springer-Veralg Berlin · Heidelberg

About this chapter

Cite this chapter

Springer, G.F. (1969). Mammalian Erythrocyte Receptors: Their Nature and their Significance in Immunopathology. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-49733-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49454-3

  • Online ISBN: 978-3-642-49733-9

  • eBook Packages: Springer Book Archive