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Anticomplementary Activity of Guinea Pig Serum Euglobulin: Its Relation to C 1 and to TAMe Esterase

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Abstract

The interaction of complement with a suitable antigen-antibody aggregate triggers a chain of chemical reactions involving consecutively the nine factors of complement (C1 to C9). The triggering reaction is identical with the material fixation of Cl to the immune complex ; this leads to the formation of Ag-Ab-C1. By its fixation Cl is converted from its chemically inert form to a highly reactive state (“fixed” or “activated” C1). The reactivity of fixed Cl is directed first against C4. Consequently C4 rapidly disappears from the fluid phase in the presence of fixed Cl. A strikingly similar process occurs spontaneously in a fraction of guinea pig serum [5, 6].

Keywords

  • Immune Complex
  • Human Complement
  • Immune Seron
  • Trigger Reaction
  • Anticomplementary Activity

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This work was done at the Institute of Medical Microbiology, Johannes Gutenberg-Universität, Mainz The work was supported by the Deutsche Forschungsgemeinschaft (Grant Kl 124/10) and by the Landesversicherungsanstalt Rheinland-Pfalz. The members of the working group are the following: Dr. W. Opferkuch, Dr. R. Ringelmann, M. Loos and the speaker.

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References

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Klein, P. (1969). Anticomplementary Activity of Guinea Pig Serum Euglobulin: Its Relation to C 1 and to TAMe Esterase. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-49733-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

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