Skip to main content

Immune Reactions in Chronic Liver Diseases

  • Chapter

Part of the Bayer-Symposium book series (BAYER-SYMP,volume 1)

Abstract

The question of whether or not human liver diseases may be initiated or perpetuated by immune processes has been raised by a number of observations, not necessarily related.

Keywords

  • Bile Duct
  • Liver Injury
  • Chronic Liver Disease
  • Viral Hepatitis
  • Primary Biliary Cirrhosis

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This investigation was supported by Grant No. AM 03846, U.S.P.H.S., National Institutes of Health.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-49733-9_22
  • Chapter length: 21 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-49733-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   139.00
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Andrade, Z., F. Paronetto, and H. Popper: Immunocytochemical studies on schistosomiasis. Amer. J. Path. 39, 589–598 (1961).

    PubMed  CAS  Google Scholar 

  • Asherson, G. L., and D. C. Dumonde: Autoantibody production in rabbits. II. Organ-specific autoantibody in rabbits injected with rat tissue. Immunology 3, 19–29 (1963).

    Google Scholar 

  • Atwater, E. C., and R. F. Jacox: The latex-fixation test in patients with liver disease. Ann. intern. Med. 58, 419–425 (1963).

    PubMed  CAS  Google Scholar 

  • Badin, J., C. Lévy et M. Cachin: Fréquence et signification des réactions de Waaler-Rose et des tests au latex positifs dans les maladies du foie. Rev. int. Hépat. 13, 655–667 (1963).

    PubMed  CAS  Google Scholar 

  • Bartholomew, L. G., A. B. Hagedorn, J. C. Cain, and A. H. Baggenstoss: Hepatitis and cirrhosis in women with positive clot test for lupus erythematosus. New Engl. J. Med. 259, 947–956 (1958).

    CAS  Google Scholar 

  • Bauer, H., F. Paronetto, R. F. Porro, A. Einheber, and H. Popper: The influence of the microbial flora on liver injury and associated gamma globulin elevation. A study in germfree rats treated with 3’-methyl-4-dimethylaminoazobenzene. Lab. Invest. 16, 847–857 (1967).

    PubMed  CAS  Google Scholar 

  • Berg, P. A., D. Doniach, and T. M. Roitt: Mitochondrial antibodies in primary biliary cirrhosis Localization of the antigen to mitochondrial membranes. J. exp. Med. 126, 277–290. (1967).

    PubMed  CrossRef  CAS  Google Scholar 

  • Bonomo, L., J. Lo Spalluto, and M. Ziff: Anti-gamma globulin factors in liver disease. Arthr. and Rheum. 6, 104–114 (1963).

    CrossRef  CAS  Google Scholar 

  • Cherrick, G. R., L. Pothier, J. J. Dufour, and S. Sherlock • Immunologic response to tetanus toxoid inoculation in patients with hepatic cirrhosis. New Engl. J. Med. 261, 340–342 (1959).

    CAS  Google Scholar 

  • De Groote, J., V. J. Desmet, P. Gedik, G. Korb, H. Popper, H. Poulsen, P. J. Scheur, M. Schmid, H. Thaler, and E. Uehlinger: A classification of chronic hepatitis. Lancet 1968 II, 626–628.

    CrossRef  Google Scholar 

  • Dóbiés, G. Y., and M. Balzas: Studies of the pathogenetic role of humoral antibodies reacting with subcellular organ antigens. I. Active immunization of rabbits with rat-organ antigens. Immunology 12, 373–387 (1967).

    Google Scholar 

  • Doniach, D., I. M. Roitt, J. G. Walker, and S. Sherlock: Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases, and their clinical implications. Clin. exp. Immunol. 1, 237–262 (1966).

    CAS  Google Scholar 

  • Donner, M. M., E. J. Simon, and P. A. Miescher: Studies on a liver specific antigen. Fed. Proc. 21, 43 (1962).

    Google Scholar 

  • Dresner, E., and P. Trombly: The latex-fixation reaction in nonrheumatic diseases. New Engl. J. Med. 261, 981–988 (1959).

    CAS  Google Scholar 

  • Elling, P., and V. Faber: Antinuclear antibodies in infectious mononucleosis. Lancet 1968 II, 918–919.

    CrossRef  Google Scholar 

  • Emetarom, N., D. Nelken, and J. H. Boss: Organ specific antigens in rat liver. Israel J. med. Sci. 3, 809–813 (1967).

    CAS  Google Scholar 

  • Engelhardt, M. V., N. T. Khramkova, and Z. A. Postnikova: Antigenic structure of mouse hepatomas. IV. Study of the liver organospecific antigen in the liver and hepatomas with fluorescent antibodies. Neoplasma (Bratisl.) 10, 133–142 (1963).

    Google Scholar 

  • Feizi, T.: Immuno¢lobulins in chronic liver disease. Gut 9, 193–198 (1968).

    PubMed  CrossRef  CAS  Google Scholar 

  • Gocke, D. J., R. Preisig, T. Q. Morris, D. C. McKay, and S. E. Bradley: Experimental viral hepatitis in the dog: Production of persistent disease in partially immune animals. J. clin. Invest. 46, 1506–1517 (1967).

    PubMed  CrossRef  CAS  Google Scholar 

  • Havens, W. P., Jr., R. M. Myerson, and J. Klatchko: Production of tetanus antitoxin by patients with hepatic cirrhosis. New Engl. J. Med. 257, 637–643 (1957).

    Google Scholar 

  • Havens, W. P., J. M. Shaffer, and C. J. Hopke Jr.: Production of antibody by patients with chronic hepatic disease. J. Immunol. 67, 347–356 (1951).

    PubMed  Google Scholar 

  • Johnson, G. D., E. J. Holoborow, and L. E. Glynn. Antibody to smooth muscle in patients with liver disease. Lancet 1965 II, 878–879.

    CrossRef  Google Scholar 

  • Johnson, G. D., E. J. Holoborow, and L. E. Glynn, Antibody to liver in lupoid hepatitis. Lancet 1966 II, 416–418.

    CrossRef  Google Scholar 

  • Kantor, F. S., and G. Klatskin: Serological diagnosis of primary biliary cirrhosis: A potential clue to pathogenesis. Trans. Ass. Amer. Phycns. 80, 267–274 (1967).

    CAS  Google Scholar 

  • Kössling, F. K., and K. H. Meyer zum Büschenfelde: Zur Induktion einer aktiven chronischen Hepatitis durch heterologe, lösliche Leberproteine. Virchows Arch. Path. Anat. 345, 365–376 (1968).

    Google Scholar 

  • Klion, F. M., and F. Schaffner: Ultrastructural features of canine hepatic auxiliary transplant rejection. Exp. molec. Path. 6, 361–369 (1967).

    PubMed  CrossRef  CAS  Google Scholar 

  • Lundkvist, U., G. C. Goeringer, and P. Perlman Immunochemical characterization of parenchymal and reticuloendothelial cells of rat liver. Exp. molec. Path. 5, 427–442 (1966).

    PubMed  CrossRef  CAS  Google Scholar 

  • Mackay, I. R., L. L. Taft, and D. C. Cowling: Lupoid hepatitis Lancet 1956 II, 1323 1326.

    Google Scholar 

  • Meyer zum Büschenfelde, K. H.: Untersuchungen über die immunobiologische Bedeutung löslicher Leberproteine. Z. ges. exp. Med. 145 131–163 (1968).

    Google Scholar 

  • Milgrom, F., Z. Maide-Tuggac, and E. Witebsky: Organ-specific antigens of liver, testicle and pituitary. J. Immunol. 94, 157–163 (1965).

    PubMed  CAS  Google Scholar 

  • Nairn, R. C., H. G. Richmond, M. G. McEntegart, and J. E. Fothergill. Immunological differences between normal and malignant cells. Brit. med. J. 1960 II, 1335–1340.

    CrossRef  Google Scholar 

  • Paronetto, F., Immune reactions and hepatic alterations in guinea pigs sensitized with altered hepatic proteins. In: Miescher, P. A., and P. Grabar (Eds.). Immunopathology, Vth International Symposium, pp 122–143. Punta Ala. New York: Grune and Stratton Inc. 1967.

    Google Scholar 

  • Paronetto, F., and H. Popper, Enhanced antibody formation in experimental acute and chronic liver injury produced by carbon tetrachloride or ally’ alcohol. Proc. Soc. exp. Biol. (N. Y.) 115, 1060–1064 (1964).

    Google Scholar 

  • Paronetto, F., and H. Popper, Aggravation of hepatic lesions in mice by in vivo localization of immune complexes (Auer hepatitis). Amer. J. Path. 47, 549–563 (1965).

    PubMed  CAS  Google Scholar 

  • Paronetto, F., and H. Popper, Chronic liver injury induced by immunologic reactions; cirrhosis following immunization with heterologous sera. Amer. J. Path. 49, 1087–1101 (1966).

    PubMed  CAS  Google Scholar 

  • Paronetto, F., and H. Popper, Hetero-iso-and autoimmune phenomena in the liver. In: Miescher, P. A., and H. J. Muller-Eberhard (Eds.), Textbook of Immunopathology. New York: Grune and Stratton 1968, 563–583.

    Google Scholar 

  • Paronetto, F., E. Rubin, and H. Popper: Local formation of y-globulin in the diseased liver and its relation to hepatic necrosis. Lab. Invest. 11, 150–158 (1962 a).

    CAS  Google Scholar 

  • Paronetto, F., F. Schaffner, R. D. Mutter, J. C. Kniffen and H. Popper: Circulating antibodies to bile ductular cells in various liver diseases. J. Amer. med. Ass. 187, 503–506 (1964 a).

    CrossRef  CAS  Google Scholar 

  • Paronetto, F., F. Schaffner, and H. Popper: Immunocytochemical and serologic observations in primary biliary cirrhosis. New Engl. J. Med. 271, 1123–1128 (1964b).

    CAS  Google Scholar 

  • Paronetto, F., Antibodies to cytoplasmic antigens in primary biliary cirrhosis and chronic active hepatitis. J. Lab. clin. Med. 69, 979–988 (1967).

    PubMed  CAS  Google Scholar 

  • Paronetto, F., N. Woolf, D. Koffler, and H. Popper: Response of the liver to soluble antigen-antibody, complexes. Gastroenterology 43, 539–546 (1962 b).

    CAS  Google Scholar 

  • Pernis, B., and F. Paronetto: The adjuvant effect of silica (tridimyte) on antibody production. Proc. Soc. exp. Biol. (N. Y.) 110, 390–392 (1962).

    CAS  Google Scholar 

  • Pinckard, R. N., and D. M. Weir: Antibodies against the mitochondrial fraction of liver after toxic liver damage in rats. Clin. exp. Immunol. 1, 33–43 (1966).

    CAS  Google Scholar 

  • Popper, H., E. Rubin, D. Gardiol, F. Schaffner, and F. Paronetto: Drug-induced liver disease. A penalty for progress. Arch. intern. Med. 115, 128–136 (1965).

    CAS  Google Scholar 

  • Renmar, H.: III Leber symposium in Vulpera. Schweiz. (in press).

    Google Scholar 

  • Rodriguez, M., F. Paronetto, F. Schaffner, and H. Popper: Antimitochondrial antibodies in jaundice following drug administration. J. Amer. med. Ass. 208, 148–150 (1969).

    CrossRef  CAS  Google Scholar 

  • Rubin, E., F. Schaffner, and H. Popper: Primary biliary cirrhosis. Chronic nonsuppurative destructive cholangitis. Amer. J. Path. 46, 387–407 (1965).

    PubMed  CAS  Google Scholar 

  • Sargent, A. U., J. Myers, B. Rose, and M. Richter: Organ and species specificity of rat hepatocellular antigens. Immunology 10, 199–210 (1966).

    PubMed  CAS  Google Scholar 

  • Scheiffarth, F., H. Warnatz, and K. Meyer: Studies concerning the importance of mononuclear cells in experimental hepatitis. J. Immunol. 98, 396–401 (1967).

    PubMed  CAS  Google Scholar 

  • Tobias, H., A. F. Safran, and F. Schaffner: Lymphocyte stimulation and chronic liver disease. Lancet 1967 I, 193–195.

    CrossRef  Google Scholar 

  • Vogt, P.: Distribution of tissue-specific antigens in centrifugal fractions of rat liver. Nature (Lond.) 182, 1807–1808 (1968).

    CrossRef  Google Scholar 

  • Walker, G., and D. Doniach: Antibodies and immunoglobulins in liver disease. Gut 9, 266 to 269 (1968).

    Google Scholar 

  • Walker, G., and D. Doniach, I. M. Roitt, and S. Sherlock: Serological tests in diagnosis of primary biliary cirrhosis. Lancet 1965 I, 827–831.

    CrossRef  Google Scholar 

  • Warnatz, H.: Das Phänomen der Lymphocytentransformation in der Pathogenese and Diagnostik von Autoimmunerkrankungen. Z. ges. exp. Med. 149, 64–90 (1969).

    CAS  Google Scholar 

  • Weiler, E.: Die Änderung der serologischen Organspezifität beim Buttergelb-Tumor der Ratte in Vergleich zu normaler Leber. Z. Naturforsch. 7b, 324–326 (1952).

    Google Scholar 

  • Whitbeck, E. G., and L. T. Rosenberg: Antigenic properties of microsomes from guinea pig spleen, liver and lymph nodes. Immunology 7, 363–374 (1964).

    PubMed  CAS  Google Scholar 

  • Whittingham, S., J. Irwin, I. I. Mackay, and M. Smalley: Smooth muscle auto-antibody in “autoimmune” hepatitis. Gastroenterology 51, 499–505 (1966).

    PubMed  CAS  Google Scholar 

  • Yoon, D. S., B. S. Shim, and T. S. Kil: Bile specific protein component in human hepatic bile. J. Lab. clin. Med. 67, 640–649 (1966).

    CAS  Google Scholar 

  • Zlotnick, A., and G. P. Rodnan: Immunoelectrophoresis of serum in “lupoid” hepatitis. Proc. Soc. exp. Biol. (N. Y.) 109, 742–746 (1962).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1969 Springer-Veralg Berlin · Heidelberg

About this chapter

Cite this chapter

Paronetto, F., Popper, H. (1969). Immune Reactions in Chronic Liver Diseases. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-49733-9_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49454-3

  • Online ISBN: 978-3-642-49733-9

  • eBook Packages: Springer Book Archive