Skip to main content
Book cover

Current Problems in Immunology pp 160–164Cite as

Histological Changes in NZB/NZW Mice

  • Chapter

  • 77 Accesses

Part of the Bayer-Symposium book series (BAYER-SYMP,volume 1)

Abstract

Evidence of the spontaneous development of an autoimmune disease in laboratory animals was first reported in 1959 by Bielschowsky, Helyer and Howie. Mice of the strain NZB/Bl develop an autoimmune haemolytic anaemia. An incomplete antibody against red blood cells, reticulocytosis, splenomegaly and a depression of haematocrit were found.

Keywords

  • Systemic Lupus Erythematosus
  • Methylene Blue
  • Autoimmune Haemolytic Anaemia
  • Neonatal Thymectomy
  • Lupus Nephropathy

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-49733-9_18
  • Chapter length: 5 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-49733-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   139.00
Price excludes VAT (USA)
Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bielschowsky, M., B. J. Helyer, and J. B. Howie: Spontaneous haemolytic anaemia in mice of the NZB/BL strain. Proc. Univ. Otago med. Sch. 37, 9 - 11 (1959).

    Google Scholar 

  • Burnet, F. M., and M. C. Holmes: Thymic changes in the mouse strain NZB in relation to the auto-immune state. J. Path. Bact. 88, 229 - 241 (1964).

    PubMed  CrossRef  CAS  Google Scholar 

  • Burnet, F. M., The natural history of the NZB/NZW F1 hybrid mouse: A laboratory model of systemic lupus erythematosus. Aust. Ann Med. 14, 185-191 (1965 a).

    PubMed  Google Scholar 

  • Burnet, F. M., Genetic investigations of autoimmune disease in mice. Nature (Lond.) 207, 368-371 (1965 b).

    CrossRef  Google Scholar 

  • Dubois, E. L., R. E. Horowitz, H. B. Demopoulos, and R. Teplitz: NZB/NZW mice as model of systemic lupus erythematosus. J. Amer. med. Ass. 195, 285 - 28k (1966).

    CrossRef  CAS  Google Scholar 

  • East, J., M. A. B. de Sousa, P. R. Prosser, and H. Jaquet: Malignant changes in New Zealand black mice. Clin. exp. Immunol. 2, 427 - 443 (1967).

    CAS  Google Scholar 

  • Helyer, B. J., and J. B. Howie: Positive lupus erythematosis tests in a cross-bred strain of mice NZB/BL-NZY/BL. Proc. Univ. Otago med. Sch. 39, 17 - 18 (1961).

    Google Scholar 

  • Helyer, B. J., Spontaneous auto-immune disease in NZB/BL mice. Brit. J. Haemat. 9, 119 - 131 (1963).

    PubMed  CrossRef  CAS  Google Scholar 

  • Hicks, J. D., and F. M. Burnet: Renal lesions in the “autoimmune” mouse strains NZB and F1 NZB x NZW. J. Path. Bact. 91, 467 - 477 (1966).

    PubMed  CrossRef  CAS  Google Scholar 

  • Holmes, M. C., and F. M. Burnet: The natural history of autoimmune disease in NZB mice. Ann. intern. Med. 59, 265 - 276 (1963).

    PubMed  CAS  Google Scholar 

  • Lambert, P.. H., and F. J. Dixon: Pathogenesis of the glomerulonephritis of NZB/W mice. J. exp. Med. 127, 507 - 521 (1968).

    PubMed  CrossRef  CAS  Google Scholar 

  • Mellors, R. C.: Autoimmune disease in NZB/BL mice. I. Pathology and pathogenesis of a model system of spontaneous glomerulonephritis. J. exp. Med. 122, 25 - 40 (1965).

    CAS  Google Scholar 

  • de Vries, M. J., and W. Hijmans: A deficient development of the thymic epithelium and autoimmune disease in NZB mice. J. Path. Bact. 91, 487 - 494 (1966).

    PubMed  CrossRef  Google Scholar 

  • de Vries: Pathological changes of thymic epithelial cells and autoimmune disease in NZB, NZW and (NZB X NZW) F1 mice. Immunology 12, 179 - 196 (1967).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für experimentelle Pathologie , Farbenfabriken Bayer AG, 56 Wuppertal-Elberfeld, Deutschland

    Dr. H. P. Hobik

Authors
  1. Dr. H. P. Hobik
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Direktor, Max-Planck-Instituts für Immunbiologie, 7800, Freiburg-Zähringen, Deutschland

    Professor Dr. Otto Westphal

  2. Direktor der Medizinischen Klinik der Universität, 7400, Tübingen, Deutschland

    Professor Dr. Dr. h. c. Hans-Erhard Bock

  3. Vorstand des Instituts für experimentelle Pathologie, Farbenfabriken Bayer AG, 5600, Wuppertal-Elberfeld, Deutschland

    Professor Dr. Ekkehard Grundmann

Rights and permissions

Reprints and Permissions

Copyright information

© 1969 Springer-Veralg Berlin · Heidelberg

About this chapter

Cite this chapter

Hobik, H.P. (1969). Histological Changes in NZB/NZW Mice. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-49733-9_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49454-3

  • Online ISBN: 978-3-642-49733-9

  • eBook Packages: Springer Book Archive