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Histological Changes in NZB/NZW Mice

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Abstract

Evidence of the spontaneous development of an autoimmune disease in laboratory animals was first reported in 1959 by Bielschowsky, Helyer and Howie. Mice of the strain NZB/Bl develop an autoimmune haemolytic anaemia. An incomplete antibody against red blood cells, reticulocytosis, splenomegaly and a depression of haematocrit were found.

Keywords

  • Systemic Lupus Erythematosus
  • Methylene Blue
  • Autoimmune Haemolytic Anaemia
  • Neonatal Thymectomy
  • Lupus Nephropathy

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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© 1969 Springer-Veralg Berlin · Heidelberg

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Hobik, H.P. (1969). Histological Changes in NZB/NZW Mice. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_18

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  • DOI: https://doi.org/10.1007/978-3-642-49733-9_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49454-3

  • Online ISBN: 978-3-642-49733-9

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