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Cell-Bound Antibodies to Streptococcal Cell-Wall Preparations

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Part of the Bayer-Symposium book series (BAYER-SYMP,volume 1)

Abstract

The walls of streptococci may be considered to have three layers: mucopeptide, polysaccharide, and protein. The mucopeptide is apparently a framework upon which the remainder of the wall is built; it is probably not immunospecific for any of the streptococcal groups. Differences in the structure of the polysaccharide form the basis for the valuable Lancefield serologic classification of haemolytic streptococci. Group A streptococci are responsible for the development of many human diseases, including streptococcal pharyngitis, tonsillitis, rheumatic fever and nephritis. The detailed structure of the protein layer of Group A streptococci is not known, but three protein constituents have been identified, i.e., M-, T-, and R-protein, which are lacking in most of the other groups. Among Group A streptococci there are more than 40 recognized immunologically specific types of M-protein. Type-specific, and group-specific serum antibody formation detectable by serologic methods usually develops after human streptococcal infection but no cytophilic antibodies have been demonstrated against the group-specific and type-specific components of the streptococcal cell-wall.

Keywords

  • Rheumatic Fever
  • Peritoneal Exudate
  • Streptococcal Pharyngitis
  • Cell Wall Fragment
  • Diisopropyl Fluorophosphate

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

These investigations were supported by the Deutsche Forschungsgemeinschaft.

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References

  • Boyden, S. V.: Cytophilic antibody in guinea-pigs with delayed-type hypersensitivity. Im-munology 7, 474 183 (1964).

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  • Nelson, D. S., and S. V. Boyden: The effect of tuberculin on peritoneal macrophages of normal and BCG-vaccinated guinea-pigs and mice. Med. Res. 1, 20 - 31 (1961).

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  • Schmidt, W. C.: The lysis of cell walls of group A streptococci by streptomyces albus enzyme treated with diisopropyl fluorophosphate. Characteristics of the lytic reaction and the soluble cell wall fragments. J. exp. Med. 121, 771 - 792 (1965).

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© 1969 Springer-Veralg Berlin · Heidelberg

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Haferkamp, O., Sodomann, CP., Heymer, B., Smith, T.B., Schmidt, W.C. (1969). Cell-Bound Antibodies to Streptococcal Cell-Wall Preparations. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_16

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  • DOI: https://doi.org/10.1007/978-3-642-49733-9_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49454-3

  • Online ISBN: 978-3-642-49733-9

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