Skip to main content

Studies on the Cytotoxicity of Lymphocytes

  • Chapter
  • 77 Accesses

Part of the Bayer-Symposium book series (BAYER-SYMP,volume 1)

Abstract

The higher organisms are equipped with two different systems for immunological defence. One system is characterized by the production of humoral antibodies, the other by the appearence of specifically sensitized lymphocytes, which are capable of direct interaction with the antigen. If the antigen happens to be attached to a cell, this interaction may lead to the destruction of the antigen carrying cell.

Keywords

  • Target Cell
  • Rheumatic Fever
  • Acute Rheumatic Fever
  • Lymphocyte Cytotoxicity
  • Time Lapse Cinematography

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-642-49733-9_11
  • Chapter length: 9 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   109.00
Price excludes VAT (USA)
  • ISBN: 978-3-642-49733-9
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   139.00
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ax, W., H. Malchow, I. Zeiss, and H. Fischer: The behaviour of lymphocytes in the process of target cell destruction in vitro. Exp. Cell Res. 53, 108 (1968).

    PubMed  CrossRef  CAS  Google Scholar 

  • Brunner, K. T.: Personal communication. Swiss Institute for Experimental Cancer Research, Lausanne, Schweiz, Bugnon 21.

    Google Scholar 

  • Brunner, K. T.: Personal communication.

    Google Scholar 

  • Fisher, D. B., and G. C. Mueller: An early alteration in the phospholipid metabolism of lymphocytes by phytohaemagglutinin. Proc. nat. Acad. Sci. (Wash.) 60, 1396 (1968).

    CrossRef  CAS  Google Scholar 

  • Ginsburg, H., and L. Sachs: Destruction of mouse and rat embryo cells in tissue culture by lymph node cells from unsensitized rats. J. cell. comp. Physiol. 66, 199 (1965).

    CrossRef  CAS  Google Scholar 

  • Hirschhorn, K., R. R. Schreibman, S. Verbo, and R. H. Gruskin: The action of streptolysin S on peripheral lymphocytes of normal subjects and patients with acute rheumatic fever. Proc. nat. Acad. Sci. (Wash.) 52, 1151 (1964).

    CrossRef  CAS  Google Scholar 

  • Holm, G.: The in vitro cytotoxicity of human lymphocytes; comparison with other cells. Exp. Cell Res. 48, 327 (1967a).

    PubMed  CrossRef  CAS  Google Scholar 

  • Holm, G., The in vitro cytotoxicity of human lymphocytes: the effect of metabolic inhibitors. Exp. Cell Res. 48, 334 (1967b).

    PubMed  CrossRef  CAS  Google Scholar 

  • Holm, G., P. Perlmann, and B. Johansson: Impaired phytohaemagglutinin-induced cytotoxicity in vitro of lymphocytes from patients with Hodgkin’s disease or chronic leukemia. Clin. exp. Immunol. 2, 351 (1967c).

    CAS  Google Scholar 

  • KAY, J. E.: Phytohaemagglutinin: An early effect on lymphocyte lipid metabolism. Nature (Lond.) 219, 172 (1968).

    CrossRef  CAS  Google Scholar 

  • Ling, N. R.: In: Lymphocyte stimulation, p. 152. Amsterdam: North-Holland Publ. Co. 1968.

    Google Scholar 

  • Möller, E.: Contact-induced cytotoxicity by lymphoid cells containing foreign isoantigens. Science 147, 873 (1965).

    CrossRef  Google Scholar 

  • Munder, P. G., M. Modolell, E. Ferber u. H. Fischer: Phospholipide in quarzgeschädigten Makrophagen. Biochem. Z. 344, 310 (1966).

    PubMed  CAS  Google Scholar 

  • Perlmann, P., H. Perlmann, and G. Holm: Cytotoxic action of stimulated lymphocytes on allogenic and autologous erythrocytes. Science 160, 306 (1968).

    PubMed  CrossRef  CAS  Google Scholar 

  • Rosenau, W.: In: Interaction of lymphoid cells with target cells in tissue culture. Cell bound antibodies, p. 75–80. ( Amos, B., H. Koprowski, Eds.). Philadelphia: Wistar Institute Press 1963.

    Google Scholar 

  • Wilson, D. B.: Quantitative studies on the behaviour of sensitized lymphocytes in vitro. J. exp. Med. 122, 143 (1965).

    PubMed  CrossRef  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1969 Springer-Veralg Berlin · Heidelberg

About this chapter

Cite this chapter

Fischer, H., Ax, W., Malchow, H., Zeiss, I. (1969). Studies on the Cytotoxicity of Lymphocytes. In: Westphal, O., Bock, HE., Grundmann, E. (eds) Current Problems in Immunology. Bayer-Symposium, vol 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49733-9_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-49733-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49454-3

  • Online ISBN: 978-3-642-49733-9

  • eBook Packages: Springer Book Archive