Abstract
The recent interest in the use of platinum compounds as antitumor agents precipitated a need for information on the pharmacokinetics and tissue distribution of these drugs. The most effective platinum compound showing antitumor activity is cisdiamminodichloride platinum(II) [cis-Pt(II)]. Unfortunately, however, it can only be labeled with platinum radionuclides of short half-life e. g. 195 mPt. Another less effective compound, platinum ethylenediamine dichloride [Pt(en)C12] can be labeled with either radioactive carbon (14C) on the ethylenediamine moiety (en) or with both 197mPt and 14C-en. The problem with the latter compound, however, is the lack of information regarding whether or not the en moiety remains with the parent compound and can be used as a monitor of drug distribution. The other remaining question is whether the distribution and kinetics of Pt(en)C12 is similar to that of cis-Pt(II).
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Conran, P.B. (1974). Pharmacokinetics of Platinum Compounds. In: Connors, T.A., Roberts, J.J. (eds) Platinum Coordination Complexes in Cancer Chemotherapy. Recent Results in Cancer Research, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49306-5_8
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DOI: https://doi.org/10.1007/978-3-642-49306-5_8
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