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Anti-Tumour Effects of Platinum Complexes in Experimental Animals

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Book cover Platinum Coordination Complexes in Cancer Chemotherapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 48))

Abstract

The discovery of new types of anti-cancer agent is not always the result of large scale screening or of working hypotheses which suggest that a particular chemical may have anti-tumour properties. Quite frequently new agents are found because of unexpected observations which may be made in fields completely unrelated to cancer chemotherapy.

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References

  1. Clarke, D. A.: Mouse Sarcoma 180. Cancer Res. Suppl. 3, 15 (1955).

    Google Scholar 

  2. Cleare, M. J., Hoeschele, J. D.: Anti-tumour platinum compounds. Relationship between structure and activity. Platinum Metals Review 17, 2 (1973).

    CAS  Google Scholar 

  3. Cleare, M. J., Hoeschele, J. D.: Studies on the anti-tumour activity of Group VIII transition metal complexes. Part I. Platinum(II)complexes. Bio inorganic Chemistry 2, 187 (1973).

    CAS  Google Scholar 

  4. Cobb, L. M., Mitchley, B. C. V.: Personal communication.

    Google Scholar 

  5. Connors, T. A.: Chemotherapy of animal tumours with platinum compounds. In: Advances in anti-microbial and anti-neoplastic chemotherapy, Vol. 2, p. 237. München, Berlin, Wien: Urban Schwarzenberg 1972.

    Google Scholar 

  6. Connors, T. A., Jones, M., Ross, W. C. J., Braddock, P. D., Khokhar, A. R., Tobe, M. L.: New platinum complexes with anti-tumour activity. Chem.-Biol. Interactions 5, 415 (1972).

    CAS  Google Scholar 

  7. Goldin, A.: Rationale of combination chemotherapy based on preclinical experiments. Cancer Chemother. Rep. (part 3 ) 4, 189 (1973).

    Google Scholar 

  8. Goldin, A., Mantel, N.: Cancer Chemother. Rep. (in press).

    Google Scholar 

  9. Goldin, A., Sandberg, J. S., Henderson, E. S., Newman, J. W.: The chemotherapy of human and animal acute leukaemia. Cancer Chemother. Rep. 55, 309 (1971).

    CAS  Google Scholar 

  10. Goldin, A., Serpick, A. A., Mantel, N.: Experimental screening procedures and clinical predictability value. Cancer Chemother. Rep. 50, 173 (1966).

    CAS  Google Scholar 

  11. Harder, H. C., Rosenberg, B.: Inhibitory effects of anti-tumour platinum compounds on DNA, RNA and protein synthesis in mammalian cells in vitro. Int. J. Cancer 6, 207 (1970).

    Article  PubMed  CAS  Google Scholar 

  12. Howle, J. A., Gale, G. R.: Cis-dichlorodiammine platinum(II) persistent and selective inhibition of DNA synthesis in vivo. Biochem. Pharmacol. 19, 2757 (1970).

    Article  PubMed  CAS  Google Scholar 

  13. Kociba, R. J., Sleight, S. D.: Acute toxicologic and pathologic effects of cis-diammine dichloroplatinum (NSC-119 875) in the male rat. Cancer Chemother. Rep. (part 1 ) 55, 1 (1971).

    Google Scholar 

  14. Kociba, R. J., Sleight, S. D., Rosenberg, B.: Inhibition of dunning ascitic leukaemia and Walker 256 carcinoma with cis-diammine-dichloroplatinum (NSC-119 875). Cancer Chemother. Rep. 54, 325 (1970).

    CAS  Google Scholar 

  15. Leonard, B. J., Eccleston, E., Jones, D., Todd, P., Walpole, A.: Anti-leukaemic and nephrotoxic properties of platinum compounds. Nature (Lond.) 234, 43 (1971).

    Article  CAS  Google Scholar 

  16. Roberts, J. J., Pascoe, J. M.: Cross-linking of complementary strands of DNA in mammalian cells by anti-tumour platinum compounds. Nature (Lond.) 235, 282 (1972).

    Article  CAS  Google Scholar 

  17. Rosenberg, B., Van Camp, L., Trosko, J. E., Mansour, V. H.: Platinum compounds: a new class of potent anti-tumour agent. Nature (Lond.) 222, 385 (1969).

    Article  CAS  Google Scholar 

  18. Schmidt, L. H., Fradkin, R., Sullivan, R., Flowers, A.: Comparative pharmacology of alkylating agents. Cancer Chemother. Rep. Suppl. 2, pt. I-III (1965).

    Google Scholar 

  19. Speer, R. J., Lapis, S., Ridgway, H., Meyers, T. D., Hill, J. M.: Cis platinous diammino dichloride (PDD) in combination therapy of leukaemia L 1210. Advances in anti-microbial and anti-neoplastic chemotherapy. Vol. 2, p. 253. München, Berlin, Wien: Urban Schwarzenberg 1972.

    CAS  Google Scholar 

  20. Talley, R. W.: Chemotherapy of a mouse reticulum cell sarcoma. Proc. Amer. Ass. Cancer Res. 11, 78 (1970).

    Google Scholar 

  21. Van Camp, L., Rosenberg, B.: Combination therapy of cis-dichloro-diammineplatinum(II) with cytoxan against the sarcoma 180 tumor in Swiss white mice. In: Advances in antimicrobial and anti-neoplastic chemotherapy. Vol. 2, p. 239. München, Berlin, Wien: Urban Schwarzenberg 1972.

    Google Scholar 

  22. Venditti, J. M., Goldin, A.: Drug synergism in anti-neoplastic chemotherapy. In: Ed. GOLDIN and HAWKING. Advances in Chemotherapy. Vol. 1, p. 397. New York: Academic Press 1964.

    CAS  Google Scholar 

  23. Welsch, C. W.: Growth inhibition of rat mammary carcinoma induced by cis platinum diamminodichloride(II). J. nat. Cancer. Inst. 47, 1071 (1971).

    PubMed  CAS  Google Scholar 

  24. Woodman, R. J., Strica, A. E., Gang, M., Kline, I., Venditti, J. M.: The enhanced therapeutic effect of cis-platinum(II) diamminodichloride against L 1210 leukaemia when combined with cyclophosphamide or 1,2-bis(3,5-dioxo-piperazine-1-yl) propane or several other anti-tumour agents. Chemotherapy 18, 169 (1973).

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. T. A. Connors
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Editors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, Fulham Road, S. W. 3, J. B., London, UK

    T. A. Connors D.Sc.

  2. Chester Beatty Research Institute, Institute of Cancer Research, Royal Cancer Hospital, S. W. 3, 6 J. B., London, UK

    J. J. Roberts D.Sc.

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© 1974 Springer-Verlag Berlin · Heidelberg

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Connors, T.A. (1974). Anti-Tumour Effects of Platinum Complexes in Experimental Animals. In: Connors, T.A., Roberts, J.J. (eds) Platinum Coordination Complexes in Cancer Chemotherapy. Recent Results in Cancer Research, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49306-5_7

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  • DOI: https://doi.org/10.1007/978-3-642-49306-5_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49308-9

  • Online ISBN: 978-3-642-49306-5

  • eBook Packages: Springer Book Archive

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