Abstract
Originally cis-tetrachlorodiammine Pt(IV) was shown to selectively inhibit bacterial cell division, resulting in the formation of E. coli filaments in which the ratio of DNA to protein was unchanged. Subsequently, cis-dichlorodiammine Pt(II) and other platinum compounds were shown to share this and other radiomimetic properties in both bacterial and mammalian cells. In this section, the ultrastructural, biochemical, antiviral and DNA binding effects of treatment of both bacteria and cultured mammalian cells are examined in an effort to provide additional information which might be useful in elucidating the mechanism(s) of action of these compounds.
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© 1974 Springer-Verlag Berlin · Heidelberg
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Harder, H.C. (1974). Effects of Platinum Compounds on Bacteria, Viruses and Cells in Culture. In: Connors, T.A., Roberts, J.J. (eds) Platinum Coordination Complexes in Cancer Chemotherapy. Recent Results in Cancer Research, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49306-5_6
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DOI: https://doi.org/10.1007/978-3-642-49306-5_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-49308-9
Online ISBN: 978-3-642-49306-5
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