Abstract
From the experimental data of Rosenberg et al. [3, 4] and others [1, 2] it is clear that various platinum complexes have good antitumour properties. Their primary action probably involves inhibition of DNA synthesis. At the National Ontological Institute in Budapest preclinical investigations of cis-platinum(II) diamminedichloride (PDD) have been carried out by Kellner, Nemeth and Somfai.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Gale, G. R., Howle, J., Walker, E. M.: Anti-tumour and anti-mitogen properties of cisdichloro(dipyridine)platinum(II). Cancer Res. 31, 950 (1971).
Leonard, B. J., Eccleston, E., Jones, D., Todd, P., Walpole, A.: Anti-leukaemic and nephrotoxic properties of platinum compounds. Nature (Lond.) 234, 43 (1971).
Rosenberg, B., Van Camp, L.: The successful regression of large solid sarcoma 180 tumors by platinum compounds. Cancer Res. 30, 1799 (1970).
Rosenberg, B., Van Camp, L., Trosko, J. E., Mansour, V. H.: Platinum compounds: a new class of potent antitumour agent. Nature (Lond.) 222, 385 (1969).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Hindy, I., Sellei, C., Varsanyi, R., Eckhardt, S. (1974). Clinical Experience with cis-Platinum (II) Diamminedichloride. In: Connors, T.A., Roberts, J.J. (eds) Platinum Coordination Complexes in Cancer Chemotherapy. Recent Results in Cancer Research, vol 48. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49306-5_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-49306-5_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-49308-9
Online ISBN: 978-3-642-49306-5
eBook Packages: Springer Book Archive