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Clinical Experience with cis-Platinum (II) Diamminedichloride

  • I. Hindy
  • C. Sellei
  • R. Varsanyi
  • S. Eckhardt
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 48)

Abstract

From the experimental data of Rosenberg et al. [3, 4] and others [1, 2] it is clear that various platinum complexes have good antitumour properties. Their primary action probably involves inhibition of DNA synthesis. At the National Ontological Institute in Budapest preclinical investigations of cis-platinum(II) diamminedichloride (PDD) have been carried out by Kellner, Nemeth and Somfai.

Keywords

Platinum Complex Platinum Compound Large Single Dose Abnormal Mitosis Oncological Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gale, G. R., Howle, J., Walker, E. M.: Anti-tumour and anti-mitogen properties of cisdichloro(dipyridine)platinum(II). Cancer Res. 31, 950 (1971).PubMedGoogle Scholar
  2. 2.
    Leonard, B. J., Eccleston, E., Jones, D., Todd, P., Walpole, A.: Anti-leukaemic and nephrotoxic properties of platinum compounds. Nature (Lond.) 234, 43 (1971).CrossRefGoogle Scholar
  3. 3.
    Rosenberg, B., Van Camp, L.: The successful regression of large solid sarcoma 180 tumors by platinum compounds. Cancer Res. 30, 1799 (1970).PubMedGoogle Scholar
  4. 4.
    Rosenberg, B., Van Camp, L., Trosko, J. E., Mansour, V. H.: Platinum compounds: a new class of potent antitumour agent. Nature (Lond.) 222, 385 (1969).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • I. Hindy
  • C. Sellei
  • R. Varsanyi
  • S. Eckhardt

There are no affiliations available

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