Clinical Experience with cis-Platinum (II) Diamminedichloride

  • I. Hindy
  • C. Sellei
  • R. Varsanyi
  • S. Eckhardt
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 48)


From the experimental data of Rosenberg et al. [3, 4] and others [1, 2] it is clear that various platinum complexes have good antitumour properties. Their primary action probably involves inhibition of DNA synthesis. At the National Ontological Institute in Budapest preclinical investigations of cis-platinum(II) diamminedichloride (PDD) have been carried out by Kellner, Nemeth and Somfai.


Platinum Complex Platinum Compound Large Single Dose Abnormal Mitosis Oncological Institute 
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    Gale, G. R., Howle, J., Walker, E. M.: Anti-tumour and anti-mitogen properties of cisdichloro(dipyridine)platinum(II). Cancer Res. 31, 950 (1971).PubMedGoogle Scholar
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    Leonard, B. J., Eccleston, E., Jones, D., Todd, P., Walpole, A.: Anti-leukaemic and nephrotoxic properties of platinum compounds. Nature (Lond.) 234, 43 (1971).CrossRefGoogle Scholar
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    Rosenberg, B., Van Camp, L.: The successful regression of large solid sarcoma 180 tumors by platinum compounds. Cancer Res. 30, 1799 (1970).PubMedGoogle Scholar
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    Rosenberg, B., Van Camp, L., Trosko, J. E., Mansour, V. H.: Platinum compounds: a new class of potent antitumour agent. Nature (Lond.) 222, 385 (1969).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • I. Hindy
  • C. Sellei
  • R. Varsanyi
  • S. Eckhardt

There are no affiliations available

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