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Interleukin-3

  • Chapter
Peptide Growth Factors and Their Receptors I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

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Abstract

Interleukin-3 (IL-3) is one of a large and growing group of growth factors which support the proliferation and differentiation of hematopoietic progenitors as well as cells committed to various myeloid lineages. The term IL-3 was initially introduced to identify a T-cell-derived lymphokine which was capable of inducing the expression of the enzyme 20α-hydroxysteroid dehydrogenase (20αSDH) in cultures of nude mouse splenic lymphocytes (Ihle et al. 1981, 1982a). This assay was developed to identify T-cell factors which might support the proliferation and differentiation of early hematopoietic progenitors capable of committing to T-lineage differentiation (Ihle and Weinstein 1986). With the purification of IL-3 to homogeneity it became evident this lymphokine had a broad spectrum of activities on hematopoietic cells and was equivalent to other biological activities which had been characterized including mast cell growth factor activity, P-cell stimulating factor activity, burst promoting activity, multi-colony stimulating factor, thy-1 inducing factor, and WEHI-3 growth factor as well as a number of other activities for which the factors had been less characterized (Ihle et al. 1983; Ihle and Weinstein 1986; Ihle 1986).

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Ihle, J.N. (1990). Interleukin-3. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_11

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