Skip to main content
SpringerLink
Log in
Book cover

Peptide Growth Factors and Their Receptors I pp 523–540Cite as

Interleukin-2

  • Chapter

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 95 / 1))

Abstract

Interleukin 2 (IL-2), one of the first lymphokines to be identified, plays a major role in the clonal expansion of T lymphocytes (T cells) by interacting with specific cell surface receptors (IL-2 receptors; Morgan et al. 1976; Smith 1984, 1988; Taniguchi et al. 1986a). Expression of both IL-2 and IL-2 receptor requires T cell activation, triggered primarily by the interaction of the antigen/MHC molecules: T cell receptor complex (CD3/Ti complex). Hence, in effect, clonal proliferation of antigen-specific T cells appears to occur via a process of signal transduction, wherein the specific interaction of antigen/MHC and the T cell receptor complex is converted into a pathway of cellular growth through the operation of the IL-2 system.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Altman A, Cardenas JM, Houghten RA, Dixon FJ, Theofilopoulos AN (1984) Antibodies of predetermined specificity against chemically synthesized peptides of human interleukin 2. Proc Natl Acad Sci USA 81: 2176–2180

    PubMed  CAS  Google Scholar 

  • Arima N, Daitoku Y, Yamamoto Y, Fujimoto K, Ohgaki S, Kojima K, Fukumori J, Matsushita K, Tanaka H, Onoue K (1987) Heterogeneity in response to interleukin 2 and interleukin 2-producing ability of adult T cell leukemic cells. J Immunol 138: 3069–3074

    PubMed  CAS  Google Scholar 

  • Arya SK, Wong-Staal F, Gallo RC (1984) T-cell growth factor gene: lack of expression in human T-cell leukemia-lymphoma virus-infected cells. Science 223: 1086–1087

    PubMed  CAS  Google Scholar 

  • Bacha P, Williams DP, Waters C, Williams JM, Murphy JR, Storm TB (1988) Interleukin 2 receptor-targeted cytotoxity. J Exp Med 167: 612–622

    PubMed  CAS  Google Scholar 

  • Ballard DW, Bohnlein E, Lowenthal JW, Wano Y, Franza BR, Greene WC (1988) HTLV-I tax induces cellular proteins that activate the NFiB element in the IL-2 receptor a-gene. Science 241: 1652–1655

    PubMed  CAS  Google Scholar 

  • Benveniste EN, Merrill JE (1986) Stimulation of oligodendrogrial proliferation and maturation by interleukin-2. Nature 321: 610–613

    PubMed  CAS  Google Scholar 

  • Bohnlein E, Lowenthal JW, Siekevitz M, Ballard DW, Franza BR, Greene WC (1988) The same inducible nuclear protein regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV. Cell 53: 827–836

    PubMed  CAS  Google Scholar 

  • Brandhuber BJ, Boone T, Kenney WC, McKay DB (1987) Three-dimentional structure of interleukin-2. Science 238: 1707–1709

    PubMed  CAS  Google Scholar 

  • Cantrell DA, Smith KA (1983) Transient expression of interleukin 2 receptors. Consequences for T cell growth. J Exp Med 158: 1895–1911

    PubMed  CAS  Google Scholar 

  • Cerretti DP, McKereghan K, Larsen A, Cantrell MA, Anderson D, Gillis S, Cosman D, Baker PE (1986) Cloning sequence and expression of bovine interleukin 2. Proc Natl Acad Sci USA 83: 3223–3227

    PubMed  CAS  Google Scholar 

  • Cosman D, Ceretti DP, Larsen A, Park L, March C, Dower S, Gillis S, Urdal D (1984) Cloning, sequence and expression of human interleukin-2 receptor. Nature 312: 768–771

    PubMed  CAS  Google Scholar 

  • Cross SL, Feinberg MB, Wolf JB, Holbroch NJ, Wong-Staal F, Leonard WJ (1987) Regulation of the human interleukin-2 receptor a chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-1. Cell 49: 47–56

    PubMed  CAS  Google Scholar 

  • Doi T, Hatakeyama M, Itoh S, Taniguchi T (1989) Transient induction of IL-2 receptor in cultured T cell lines by HTLV-1 LTR-linked tax-1 gene. EMBO J 8: 1953–1958

    PubMed  CAS  Google Scholar 

  • Dukovich M, Wano Y, Thuy JB, Katz P, Cullen BR, Kehrl JH, Greene WC (1987) A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature 327: 518–522

    PubMed  CAS  Google Scholar 

  • Durand DB, Bush MR, Margan JG, Weiss A, Crabtree GR (1987) A 275 base pair fragment at the 5’ end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J Exp Med 165: 395–407

    PubMed  CAS  Google Scholar 

  • Durand DB, Shaw J-P, Bush MR, Replogle RE, Belagaje R, Crabtree GR (1988) Characterization of antigen receptor, response elements with the interleukin-2 enhancer. Mol Cell Biol 8: 1715–1724

    PubMed  CAS  Google Scholar 

  • Efrat S, Pilo S, Kaempfer R (1982) Kinetics of induction and molecular size of mRNAs encoding human interleukin-2 and y-interferon. Nature 297: 236–239

    PubMed  CAS  Google Scholar 

  • Evans SW, Beckner SK, Farrar WL (1987) Stimulation of specific GTP binding and hydrolysis activities in lymphocyte membrane by interleukin-2. Nature 325: 166–168

    PubMed  CAS  Google Scholar 

  • Farrar WL, Anderson WB (1985) Interleukin-2 stimulates association of protein kinase C with plasma membrane. Nature 315: 233–235

    PubMed  CAS  Google Scholar 

  • Felber BK, Paskalis H, Kleinman-Ewing C, Wong-Staal F, Pavlakis G (1985) The pX protein of HTLV-1 is a transcriptional activator of its long terminal repeats. Science 229: 675–679

    PubMed  CAS  Google Scholar 

  • Flexner C, Hugin A, Moss B (1987) Prevention of Vaccinia virus infection in immunodeficient mice by vector-directed IL-2 expression. Nature 330: 259–262

    PubMed  CAS  Google Scholar 

  • Fujii M, Sugamura K, Sano K, Nakai M, Sugita K, Hinuma Y (1986) High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells. J Exp Med 163: 550–562

    PubMed  CAS  Google Scholar 

  • Fujisawa J, Seiki M, Kiyokawa T, Yoshida M (1985) Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor. Proc Natl Acad Sci USA 82: 2277–2281

    PubMed  CAS  Google Scholar 

  • Fujita T, Takaoka C, Matsui H, Taniguchi T (1984) Structure of the human interleukin 2 gene. Proc Natl Acad Sci USA 80: 7437–7441

    Google Scholar 

  • Fujita T, Shibuya H, Ohashi K, Yamanishi K, Taniguchi T (1986) Regulation of human interleukin-2 gene: functional DNA sequences in the 5’ flanking region for the gene expression in activated T lymphocytes. Cell 46: 401–407

    PubMed  CAS  Google Scholar 

  • Fuse A, Fujita T, Yasumitsu N, Kashima N, Hasegawa K, Taniguchi T (1984) Organization and structure of the mouse interleukin-2 gene. Nucleic Acids Res 12: 9323–9331

    PubMed  CAS  Google Scholar 

  • Gootenberg JE, Ruscetti FW, Mier JW, Gazdar A, Gallo RC (1981) Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor. J Exp Med 154: 1403–1418

    PubMed  CAS  Google Scholar 

  • Greene WC, Leonard WC (1986) The human interleukin-2 receptor. Annu Rev Immunol 4: 69–96

    PubMed  CAS  Google Scholar 

  • Greene WC, Robb RJ, Svetlik PB, Rusk CM, Depper JM, Leonard WJ (1985) Stable expression of cDNA encoding the human interleukin-2 receptor in eukaryotic cells. J Exp Med 162: 363–368

    PubMed  CAS  Google Scholar 

  • Grimm EA, Mazumder A, Zhang HZ, Rosenberg SA (1982) Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes. J Exp Med 155: 1823–1841

    PubMed  CAS  Google Scholar 

  • Hatakeyama M, Minamoto S, Uchiyama T, Hardy RR, Yamada G, Taniguchi T (1985) Reconstitution of functional receptor for human interleukin-2 in mouse cells. Nature 318: 467–470

    PubMed  CAS  Google Scholar 

  • Hatakeyama M, Minamoto S, Taniguchi T (1986) Intracytoplasmic phosphorylation sites of Tac antigen (p55) are not essential for the conformation, function, and regulation of the human interleukin 2 receptor. Proc Natl Acad Sci USA 83: 9650–9654

    PubMed  CAS  Google Scholar 

  • Hatakeyama M, Doi T, Kono T, Maruyama M, Minamoto S, Mori H, Kobayashi H, Uchiyama T, Taniguchi T (1987) Transmembrane signaling of interleukin 2 receptor: conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules. J Exp Med 166: 362–375

    PubMed  CAS  Google Scholar 

  • Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T (1989) Interleukin-2 receptor ß chain gene: generation of three receptor forms by cloned human a and ß chain cDNA’s. Science 244: 551–556

    PubMed  CAS  Google Scholar 

  • Hattori T, Uchiyama T, Toibana T, Takatsuki K, Uchino H (1981) Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 58: 645–647

    PubMed  CAS  Google Scholar 

  • Henny CS, Kuribayashi K, Kern DE, Gillis S (1981) Interleukin-2 augments natural killer cell activity. Nature 291: 335–338

    Google Scholar 

  • Herrmann T, Diamantstein T (1988) The human intermediate-affinity interleukin 2 receptor consists of two distinct, partially homologous glycoproteins. Eur J Immuno118: 1051–1057

    Google Scholar 

  • Holbrook NJ, Smith KA, Fornace AJ, Comeau CM, Wiskocil RL, Crabtree GR (1984) T-cell growth factor: complete nucleotide sequence and organization of the gene in normal and malignant cells. Proc Natl Acad Sci USA 81: 1634–1638

    PubMed  CAS  Google Scholar 

  • Inoue J, Seiki M, Taniguchi T, Tsuru S, Yoshida M (1986) Induction of interleukin 2 receptor gene expression by p40x encoded by human T-cell leukemia virus type I. EMBO J 5: 2883–285

    PubMed  CAS  Google Scholar 

  • Ishida N, Kanamori H, Noma T, Nikaido T, Sabe H, Suzuki N, Shimizu A, Honjo T (1985) Molecular clonig and structure of the human interleukin-2 receptor gene. Nucleic Acids Res 13: 7579–7589

    PubMed  CAS  Google Scholar 

  • Ju G, Collins L, Kaffka KL, Tsien W-H, Chizzonite R, Crowl R, Bhatt R, Kilian PL (1987) Structure-function analysis of human interleukin-2. J Biol Chem 262: 5723–5731

    PubMed  CAS  Google Scholar 

  • Jung LKL, Hara T, Fu SM (1984) Detection and functional studies of p60–65 ( Tac antigen) on activated human B cells. J Exp Med 160: 1597–1602

    PubMed  CAS  Google Scholar 

  • Kashima N, Nishi-Takaoka C, Fujita T, Taki S, Yamada G, Hamuro J, Taniguchi T (1985) Unique structure of murine interleukin-2 as deduced from cloned cDNAs. Nature 313: 402–404

    PubMed  CAS  Google Scholar 

  • Kelley VE, Gaulton GN, Hattori M, Ikegami H, Eisenbarth G, Strom TB (1988) Antiinterleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis. J Immunol 140: 59–61

    PubMed  CAS  Google Scholar 

  • Kirkman RL, Barrett LV, Gaulton GN, Kelly VE, Ythier A, Strom TB (1985) Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice. J Exp Med 162: 358–362

    PubMed  CAS  Google Scholar 

  • Kiyokawa T, Seiki M, Iwashita S, Imagawa K, Shimizu F, Yoshida M (1985) p27x-m and p21 x-“’ proteins encoded by pX sequence of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 82: 8359–8363

    Google Scholar 

  • Kondo S, Shimizu A, Maeda M, Tagaya A, Yodoi J, Honjo T (1986) Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection. Nature 320: 75–77

    PubMed  CAS  Google Scholar 

  • Kondo S, Kinoshita M, Shimizu A, Saito Y, Konishi M, Sabe H, Honjo T (1987) Expression and functional characterization of artificial mutants of interleukin-2 receptor. Nature 327: 64–67

    PubMed  CAS  Google Scholar 

  • Koyasu S, Yodoi J, Nikaido T, Tagaya Y, Taniguchi Y, Honjo T, Yahara I (1986) Expression of interleukin 2 receptors on interleukin 3 dependent cell lines. J Immunol 136: 984–987

    PubMed  CAS  Google Scholar 

  • Kuo L-M, Robb RJ (1986) Structure-function relationships for the IL-2 receptor system I. Localization of a receptor binding site on IL-2. J Immunol 137: 1538–1543

    PubMed  CAS  Google Scholar 

  • LeGrue SJ (1988) Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers? Lymphokine Res 7: 187–200

    PubMed  CAS  Google Scholar 

  • Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC (1982) A monoclonal antibody that appears to recognize the receptor for human T cell growth factor; partial characterization of the receptor. Nature 300: 267–269

    PubMed  CAS  Google Scholar 

  • Leonard WJ, Depper JM, Crabtree GR, Rudikoff S, Pumphrey J, Robb RJ, Svetlik PB, Peffer N, Waldmann TA, Greene WC (1984) Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311: 626–631

    PubMed  CAS  Google Scholar 

  • Leonard WJ, Depper JM, Kanehisa M, Kronke M, Peffer N, Svetlik PB, Sullivan M, Greene WC (1985) Structure of the human interleukin-2 receptor gene. Science 230: 633–639

    PubMed  CAS  Google Scholar 

  • Leung K, Nabel GJ (1988) HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kB-like factor. Nature 333: 776–778

    PubMed  CAS  Google Scholar 

  • Lotze MT, Grimm EA, Mazumder A, Strausser SA, Rosenberg SA (1981) Lysis of fresh and cultured autologous tumor by lymphocytes cultured in T-cell growth factor. Cancer Res 41: 4420–4425

    PubMed  CAS  Google Scholar 

  • Malkovsky M, Loveland B, North M, Asherson GL, Gao L, Ward P, Fiers W (1987) Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes. Nature 325: 262–264

    PubMed  CAS  Google Scholar 

  • Maruyama M, Shibuya H, Harada H, Hatakeyama M, Seiki M, Fujita T, Inoue J-I, Yoshida M, Taniguchi T (1987) Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell 48: 343–350

    PubMed  CAS  Google Scholar 

  • Mills GB, Stewart DJ, Mellors A, Gelfand EW (1986) Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells J Immunol 136: 3019–3024

    PubMed  CAS  Google Scholar 

  • Mills GB, Girard P, Grinstein S, Gelfand EW (1988) Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C. Cell 55: 91–100

    PubMed  CAS  Google Scholar 

  • Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuka Y, Shiraishi Y, Nagata K, Hinuma Y (1981) Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukemic T cells: Nature 294: 770–771

    CAS  Google Scholar 

  • Morgan DA, Ruscetti FW, Gallo RC (1976) Selective in vitro growth of T-lymphocytes from normal human bone marrows. Science 193: 1007–1008

    PubMed  CAS  Google Scholar 

  • Nabel G, Baltimore D (1987) An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711–713

    PubMed  CAS  Google Scholar 

  • Nabel GJ, Gorka C, Baltimore D (1988) T-cell specific expression of interleukin 2: evidence for a negative regulatory site. Proc Natl Acad Sci USA 85: 2934–2938

    PubMed  CAS  Google Scholar 

  • Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M, Uchiyama T, Yodoi J, Honjo T (1984) Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 311: 631–635

    PubMed  CAS  Google Scholar 

  • Perentesis JP, Genbauffe FS, Veldman SA, Galeotti GL, Livingston DM, Bodley JM, Murphy J (1988) Expression of diphtheria toxin fragment A and hormone-toxin fusion proteins in toxin-resistant yeast mutants. Proc Natl Acad Sci USA 85: 8386–8390

    PubMed  CAS  Google Scholar 

  • Ramshaw IA, Andrew ME, Phillips SM, Boyle DB, Coupar BEH (1987) Recovery of immunodeficient mice from a vaccinia virus/IL-2 recombinant infection. Nature 329: 545–546

    PubMed  CAS  Google Scholar 

  • Reed JC, Sabath DE, Hoover RG, Prystowsky MB (1985) Recombinant interleukin-2 regulates levels of c-myc mRNA in a cloned murine T lymphocytes. Mol Cell Biol 5: 3361–3368

    PubMed  CAS  Google Scholar 

  • Reeves R, Spies AG, Nissen MS, Buck CD, Weingerg AD, Barr PJ, Magnuson NS, Magnuson JA (1986) Molecular cloning of a functional bovine interleukin 2 cDNA. Proc Natl Acad Sci USA 83: 3228–3232

    PubMed  CAS  Google Scholar 

  • Robb RJ (1986) Conversion of low-affinity interleukin 2 receptors to a high-affinity state following fusion of cell membranes. Proc Natl Acad Sci USA 83: 3992–3996

    Google Scholar 

  • Robb RJ, Greene WC, Rusk CM (1984) Low and high affinity cellular receptors for interleukin-2. Implications for the level of Tac antigen. J Exp Med 154: 1455–1474

    Google Scholar 

  • Rosenberg SA, Spiess P, Lafreniere R (1986) A new approach to the adoptive immunotheraphy of cancer with tumor-infiltrating lymphocytes. Science 233: 1318–1321

    PubMed  CAS  Google Scholar 

  • Rosenberg SA (1988) The development of new immunotherapies for the treatment of cancer using interleukin-2. Ann Surg 208: 121–135

    PubMed  CAS  Google Scholar 

  • Rosenberg SA, Lotze MT, Muul LM, Chang AE, Avis FP, Leitman S, Linehan WM, Robertson CN, Lee RE, Rubin JT, Seipp CA, Simpson CG, White DE (1987) A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 316: 889–897

    PubMed  CAS  Google Scholar 

  • Saragivo H, Malek T (1987) The murine interleukin 2 receptor: irreversible cross-linking of radiolabeled interleukin 2 to high-affinity interleukin 2 receptors reveals a noncovalently associated subunit. J Immunol 139: 1918–1926

    Google Scholar 

  • Seigel U, Harper ME, Wong-Staal F, Gallo RC, Nash WG, O’Brien SJ (1984) Gene for T-cell growth factor: location on human chromosome 4q and feline chromosome B1. Science 223: 175–178

    PubMed  CAS  Google Scholar 

  • Seiki M, Hattori S, Hirayama Y, Yoshida M (1983) Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA 80: 3618–3622

    PubMed  CAS  Google Scholar 

  • Sharon M, Klausner RD, Cullen BR, Chizzonite R, Leonard WJ (1986) Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 234: 859–863

    PubMed  CAS  Google Scholar 

  • Shaw J-P, Utz-PJ, Durand DB, Toole JJ, Emmel EA, Crabtree GR (1988) Identifica- tion of a putative regulator of early T cell activation genes. Science 241: 202–205

    CAS  Google Scholar 

  • Shibuya H, Yoneyama M, Taniguchi T (1989) Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes. Int Immunol 1: 43–49

    PubMed  CAS  Google Scholar 

  • Siebenlist U, Durand DB, Bressler P, Holbrook NJ, Norris CA, Kamoun M, Kant JA, Crabtree GR (1986) Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chroramphenicol acetyltransferase gene during activation of T cells. Mol Cell Biol 6: 3042–3049

    PubMed  CAS  Google Scholar 

  • Smith KA (1984) Interleukin 2. Annu Rev Immunol 2: 319–333

    CAS  Google Scholar 

  • Smith KA (1988) Interleukin 2: inception, impact and implications. Science 240: 1169–1176

    PubMed  CAS  Google Scholar 

  • Sodroski JG, Rosen CA, Haseltine WA (1984) Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science 225: 381–385

    PubMed  CAS  Google Scholar 

  • Steiner G, Tschachler E, Tani M, Malek TR, Shevach EM, Holter W, Knapp W, Wolff K, Stingl G (1986) Interleukin 2 receptors on cultured murine epidermal Langerhans cells. J Immunol 137: 155–159

    PubMed  CAS  Google Scholar 

  • Stern JB, Smith KA (1986) Interleukin-2 induction of T-cell Gi progression and c-myb expression. Science 233: 203–206

    PubMed  CAS  Google Scholar 

  • Sugamura K, Nakai S, Fujii M, Hinuma Y (1985) Interleukin-2 inhibits in vitro growth of human T cell lines carring retrovirus. J Exp Med 161: 1243–1248

    PubMed  CAS  Google Scholar 

  • Suzuki N, Matsunami N, Kanamori H, Ishida N, Shimizu A, Yaoita Y, Nikaido T, Honjo T (1987) The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts. J Biol Chem 262: 5079–5086

    PubMed  CAS  Google Scholar 

  • Taniguchi T (1988) Regulation of cytokine gene expression. Annu Rev Immunol 6: 439–464

    PubMed  CAS  Google Scholar 

  • Taniguchi T (1989) Structure and regulation of the genes operating in type I IFN and IL-2 systems. In: Yamamura Y (ed) Recent progress in cytokine research. Medical View, Tokyo, pp 75–88

    Google Scholar 

  • Taniguchi T, Matsui H, Fujita T, Takaoka C, Kashima N, Yoshimoto R, Hamuro J (1983) Structure and expression of a cloned cDNA for human interleukin-2. Nature 302: 305–310

    PubMed  CAS  Google Scholar 

  • Taniguchi T, Matsui H, Fujita T, Hatakeyama M, Kashima N, Fuse A, Hamuro J (1986a) Molecular analysis of the interleukin-2 system. Immunol Rev 92: 121–133

    PubMed  CAS  Google Scholar 

  • Taniguchi T, Fujita T, Hatakeyama M, Mori H, Matsui H, Sato T, Hamuro J, Minamoto S, Yamada G, Shibuya H (1986b) Interleukin-2 and its receptor: structure and functional expression of the genes. Cold Spring Harbor Symp Quant Biol 51: 577–586

    PubMed  CAS  Google Scholar 

  • Teshigawara K, Wang H-M, Kato K, Smith KA (1987) Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J Exp Med 165: 223–238

    PubMed  CAS  Google Scholar 

  • Tsudo M, Kozak RW, Goldman CK, Waldmann TA (1986) Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multi-chain interleukin 2 receptor complex. Proc Natl Acad Sci USA 83: 9694–9698

    PubMed  CAS  Google Scholar 

  • Uchiyama T, Broder S, Waldmann TA (1981) A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac(+) cells. J Immunol 126: 1393–1387

    PubMed  CAS  Google Scholar 

  • Valge VE, Wong JGP, Datlof BM, Sinskey AJ, Rao A (1988) Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells. Cell 55: 101–112

    PubMed  CAS  Google Scholar 

  • Waldmann TA, Goldman CK, Robb RJ, Depper JM, Leonard WJ, Sharrow SO, Bongiovanni KF, Korsmeyer SJ, Greene WC (1984) Expression of interleukin 2 receptors on activated human B cells. J Exp Med 160: 1450–1466

    PubMed  CAS  Google Scholar 

  • Wang H-M, Smith KA (1987) The interleukin 2 receptor. Functional consequences of its bimolecular structure. J Exp Med 166: 1055–1069

    PubMed  CAS  Google Scholar 

  • Weiss A, Imboden J, Hardy K, Manger B, Terhost C, Stobo J (1986) The role of the T3/antigen receptor complex in T-cell activation. Annu Rev Immunol 4: 593–620

    PubMed  CAS  Google Scholar 

  • Weissman AM, Harford JB, Svetlik PB, Leonard WJ, Depper JM, Waldmann TA, Greene WC, Klausner RD (1986) Only high-affinity receptors for interleukin 2 mediate internalization of ligand. Proc Natl Acad Sci USA 83: 1463–1466

    PubMed  CAS  Google Scholar 

  • Wong-Staal F, Gallo RC (1985) Human T-lymphotropic retroviruses. Nature 317: 395–403

    PubMed  CAS  Google Scholar 

  • Yamada G, Kitamura Y, Sonoda H, Harada H, Taki S, Mulligan RC, Osawa H, Diamantstein T, Yokoyama S, Taniguchi T (1987) Retroviral expression of the human IL-2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity. EMBO J 6: 2705–2709

    PubMed  CAS  Google Scholar 

  • Yokota T, Arai N, Lee F, Rennick D, Mosmann T, Arai K (1986) Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth factor activity after transfection of monkey cells. Proc Natl Acad Sci USA 82: 68–72

    Google Scholar 

  • Yoshida M, Seiki M (1987) Recent advances in the molecular biology of HTLV-1: trans-activation of viral and cellular genes. Annu Rev Immunol 5: 541–560

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. M. Hatakeyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Taniguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory of Chemoprevention, National Cancer Institute, Bldg. 41, Room C-629, 20892, Bethesda, MD, USA

    Michael B. Sporn M. D.  & Anita B. Roberts Ph. D.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Hatakeyama, M., Taniguchi, T. (1990). Interleukin-2. In: Sporn, M.B., Roberts, A.B. (eds) Peptide Growth Factors and Their Receptors I. Handbook of Experimental Pharmacology, vol 95 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49295-2_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-49295-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49297-6

  • Online ISBN: 978-3-642-49295-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation