Abstract
Increasing public demand for greater assurance of safety regarding chemicals found in the human environment has led, in recent years, to a tremendous increase in research and regulatory activity in the field of toxicology. While the ultimate goal is human health, information for use in the safety evaluation of chemicals is derived primarily from various types of bioassay studies using animal models. The objective of long-term tests in rodents is to assess potential chronic toxicity, including carcinogenicity, which would not be evident in tests of shorter duration.
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Grice, H.C. (1984). The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies. In: Grice, H.C. (eds) The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies. Current Issues in Toxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49293-8_1
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