Augmented Immunogenicity of Tumor Cell Homogenates Infected with Influenza Virus

Boone, C. W.

doi:10.1007/978-3-642-49284-6_57

C. W. Boone³⁶

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 47))

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Abstract

We have studied the use of influenza virus to augment the immunogenicity of tumor-transplantation antigens (TTA) isolated from tumor homogenates [1, 2, 3, 4]. The data to be presented here refer to a transplantable SV 40-induced fibrosarcoma in BALB/c mice infected with the WSA strain of mouse-adapted influenza virus [1]. We have obtained similar results with methylcholanthrene-induced fibrosarcomas and a Moloney virus-induced lymphoma of mice. In addition, the Hong Kong strain of influenza virus appears to be as effective as the WSA strain after adaption to growth in mouse cells.

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References

Boone, C. W., Blackman, K., Brandchaft, P.: Tumor immunity induced in mice with cell-free homogenates of influenza virus-infected tumor cells. Nature (Lond.) 231, 265 (1971).
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Boone, C. W., Blackman, K.: Augmented immunogenicity of tumor cell homogenates infected with influenza virus. Cancer Res. 32, 1018 (1972).
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Boone, C. W., Orme, T. W., Blackman, K., Gillette, R: Preparation of membrane fractions with augmented tumor transplantation antigen activity from tumor cells infected with influenza virus. J. nat. Cancer Inst. 51, 1141 (1973).
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Authors and Affiliations

Cell Biology Section, Viral Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Md., USA
C. W. Boone

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C. W. Boone
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Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, F-94, Villejuif, France
Georges Mathé (Professor) (Professor)
Children’s Cancer Research Foundation, 35 Binney Street, 02115, Boston, MA, USA
Roy Weiner M.D.

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Boone, C.W. (1974). Augmented Immunogenicity of Tumor Cell Homogenates Infected with Influenza Virus. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_57

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DOI: https://doi.org/10.1007/978-3-642-49284-6_57
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-49286-0
Online ISBN: 978-3-642-49284-6
eBook Packages: Springer Book Archive

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