Abstract
If a virologist-pathologist team were to undertake to construct a virus designed to induce reproductive failure the most important attribute sought would likely be the ability to enter and to destroy mitotic cells. Such an agent would, theoretically, be infectious for the fetus throughout gestation. An attack upon sites of cell proliferation at critical stages of organogenesis could result in malformations incompatible with life, or induce severe developmental defects. Considering that critical phases of growth and differentiation of various organs occur sequentially throughout fetal development, infections even in late gestation or in the perinatal period would still be capable of producing disabling or fatal sequelae. In a relatively stable adult cell population only mild infection would be expected. Hence, a pregnant host could harbor an unapparent or latent infection with an agent which would be highly virulent or lethal for her progeny.
Supported by U.S.P.H.S. Grants NB-05545 and CA-06010, and by National Cancer Institute Research Career Award CA-22,652.
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Margolis, G., Kilham, L., Davenport, J. (1967). A Model for Virus Induced Reproductive Failure: Theory, Observations and Speculations. In: Benirschke, K. (eds) Comparative Aspects of Reproductive Failure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48949-5_21
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