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Part of the book series: Adverse Effects of Herbal Drugs ((HERBAL DRUGS,volume 2))

Abstract

Like Panax ginseng and its congeners (see our monograph on Panax ginseng in the preceding volume), Eleutherococcus senticosus (Ruprecht et Maximowicz) ex Maxim. belongs to the family Araliaceae. Another synonym frequently used in the international literature, and preferred by Asian scientists, is Acanthopanax senticosus (Ruprecht et Maximowicz) Harms. The plant is also known by the more popular names Siberian ginseng, taiga root, eleuthero, thorny ginseng, touch-me-not, and devil’s shrub. In the USSR, the plant is called Eleutherokokk koljucij. In China and in Japan it is known as Wujiapi or Ciwujia [1–5].

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References

  1. Baranov AI (1982) Medicinal uses of Ginseng and related plants in the Soviet Union: recent trends in the Soviet literature. J Ethnopharmacol 6:339–353

    Article  PubMed  CAS  Google Scholar 

  2. Farnsworth NR, Kinghorn AD, Soejarto DD, Waller DP (1985) Siberian Ginseng (Eleutherococcus senticosus): Current status as an adaptogen. In: Wagner H, Hikino H, Farnsworth NR (eds) Economic and Medicinal Plant Research vol 1. London: Academic Press, pp 217–284

    Google Scholar 

  3. Phillipson JD, Anderson LA (1984) Ginseng — quality, safety and efficacy? Pharm J 232:161–165

    CAS  Google Scholar 

  4. Steinegger E, Hänsel R (1988) Lehrbuch der Pharmakognosie und Phytopharmazie 4. Auflage. Berlin: Springer-Verlag, pp 612–628

    Google Scholar 

  5. Tyler VE, Brady LR, Robbers JE (1988) Pharmacognosy 9th ed. Philadelphia: Lea & Febiger, p 471

    Google Scholar 

  6. Sprecher E (1977) Problematik moderner Drogen: Ginseng — Taigawurzel — Teufelskralle. In: Schriftenreihe der Bundesapothekerkammer, Vol. 5, Gelbe Reihe: XV. Internationaler Fortbildungskurs für praktische und wissenschaftliche Pharmazie. Meran: Bundesapothekerkammer, pp 71–95

    Google Scholar 

  7. Siegel RK (1979) Ginseng abuse syndrome — Problems with the Panacea. JAMA 241:1614–1615

    Article  PubMed  CAS  Google Scholar 

  8. Baldwin CA, Anderson LA, Phillipson JD (1986) What pharmacists should know about ginseng. Pharm J 583–586

    Google Scholar 

  9. Brekhman II, Dardymov IV (1969) New substances of plant origin which increase nonspecific resistance. Ann Rev Pharmacol 9:419–430

    Article  PubMed  CAS  Google Scholar 

  10. Brekhman II, Kirillov OI (1968) Ginseng and Eleutherococcus as sources of a new type of drugs. Rast Resur 4:3–13

    Google Scholar 

  11. Hahn DR, Kasai R, Kim JH et al. (1986) The glycosides of Araliaceous drugs and their biological activities. Saengyak Hakhoechi 17:78–84

    CAS  Google Scholar 

  12. Lui JHC, Staba EJ (1980) Ginsenosides of various ginseng plants and selected products. Lloydia 43:340–346

    CAS  Google Scholar 

  13. Ro HS, Lee SY, Han BH (1977) Studies on the lignan glycoside of Acanthopanax cortex. J Pharm Soc Korea 21:81–86

    CAS  Google Scholar 

  14. Shih C (1981) Study on chemical constituents in Acanthopanax senticosus Harms. Yao Hsueh T’ung Pao 16:53

    Google Scholar 

  15. Wagner H, Wurmböck A (1977) Chemie, Pharmakologie und Dünnschichtchromatographie der Ginseng- und Eleutherococcus-Droge. Dtsch Apoth Ztg 117:743–748

    CAS  Google Scholar 

  16. Wagner H, Heur YH, Obermeier A et al. (1982) Die DC- und HPLC-Analyse der Eleutherococcus Droge. Planta Med 44:193–198

    Article  PubMed  CAS  Google Scholar 

  17. Lapchik VF, Frolova GM, Ovodov YS (1967) Quantitative determination of Eleutherococcus senticosus glycosides. Rast Resur 5:455–457

    Google Scholar 

  18. Lapchik VF, Ovodov YS (1969) Determining the amount of biologically active substances in the raw material and drug preparations of Eleutherococcus senticosus. Visn Kyyivsk Univ Ser Biol 11:105–108

    Google Scholar 

  19. Ovodov YS, Ovodova RG, Solo’veva TF et al. (1965) Glycosides from Eleutherococcus. I. Isolation and some properties of eleutherosides band E. Khim Prirodn Soedin Akad Nauk Uz SSSR 1:3–7

    Google Scholar 

  20. Wagner H (1980) Analytik von Eleutherococcus-Extrakten. Naturheilpraxis 8:928–930

    Google Scholar 

  21. Obermeier A (1980) Zur Analytik der Ginseng- und Eleutherococcusdroge. Dissertation. Munich: University of Munich

    Google Scholar 

  22. Anetai M, Jamagishi T, Kaneshima H (1987) Quantitative determination of pharmacologically active constituents in the stems of Acanthopanax senticosus collected in Hokkaido. Hokkaidoritsu Eisei Kenkyushoho 37:85–87

    Google Scholar 

  23. Chung BS, Kim YH (1986) Studies on the constituents of Acanthopanax koreanum. Saengyak Hakhoechi 17:62–66

    CAS  Google Scholar 

  24. Fang JN, Proksch A, Wagner H (1985) Immunologically active polysaccharides of Acanthopanax senticosus. Phytochemistry 24:2619–2622

    Article  CAS  Google Scholar 

  25. Wagner H, Proksch A, Riess-Maurer I et al. (1985) Immunstimulierend wirkende Polysaccharide (Heteroglykane) aus höheren Pflanzen. Arzneim Forsch 35:1069–1075

    CAS  Google Scholar 

  26. Yang JC, Liu JS (1986) Dynamic study of the interferon-stimulating effect of a polysaccharide of Acanthopanax senticosus on leukemic cell culture. Chung Hsi I Chieh Ho Tsa Chih 6:231–233

    PubMed  CAS  Google Scholar 

  27. Zhu C, Tu G, Shen M (1982) Effect of polysaccharide from Acanthopanax senticosus on mouse serum type-specific antibodies. Yaoxue Tongbao 17:178

    CAS  Google Scholar 

  28. Yun-Choi HS, Kim JH, Lee JR (1987) Potential inhibitors of platelet aggregation from plant sources, III. J Nat Prod 50:1059–1064

    Article  PubMed  CAS  Google Scholar 

  29. Anton R (1987) Reflexions sur quelques nouvelles acquisitions en phytotherapie. J Pharm Belg 42:138–151

    PubMed  CAS  Google Scholar 

  30. Fulder S (1980) The drug that builds Russians. New Scientist 21:576–579

    Google Scholar 

  31. Fulder S (1981) Ginseng and the hypothalamic-pituitary control of stress. Am J Chin Med 9:112–118

    Article  PubMed  CAS  Google Scholar 

  32. Minor JR (1979) Ginseng: fact or fiction? Hosp Formul 14:186–192

    Google Scholar 

  33. Owen RT (1981) Ginseng: A pharmacological profile. Drugs of Today 17:343–351

    CAS  Google Scholar 

  34. Curtze A (1980) Die Arzneipflanze Eleutherococcus senticosus Maxim. in der Bundesrepublik Deutschland. Der Kassenarzt 20:497–503

    Google Scholar 

  35. Vogt HH (1981) Eleutherococcus senticosus — Konkurrent für Ginseng. Naturwiss Rundschau 34:305–306

    Google Scholar 

  36. Anisimov MM, Suprunov NI, Prokofeva NG (1972) Effect of compounds isolated from Araliaceae family plants on the in vitro biosynthesis of protein. Rast. Resur 8:378–380

    CAS  Google Scholar 

  37. Brekhman II, Dardymov IV (1969) Pharmacological investigation of glycosides from Ginseng und Eleutherococcus. Lloydia 32:46–51

    PubMed  CAS  Google Scholar 

  38. Nakagawa S, Yoshida S, Hirao Y et al. (1985) Cytoprotective activity of components of garlic, ginseng and ciwujia on hepatocyte injury induced by carbon tetrachloride in vitro. Hiroshima J Med Sci 34:303–309

    PubMed  CAS  Google Scholar 

  39. Yang J, Xu H, Liu J (1984) Interferon induction by Acanthopanax senticosus polysaccharide and by sodium carboxymethyl starch in S 801 and S 7811 cell culture. Zhonghua Weishengwuxue He Mianyixue Zazhi 4:329–330

    Google Scholar 

  40. Monakhov BV (1965) Effect of an extract of the roots of Eleutherococcus senticosus on toxicity and antitumor activity of cyclophosphane. Vopr Oncol 11:60–63

    CAS  Google Scholar 

  41. Sakharova TA, Revazova YA, Barenboim GM (1985) The effect of Eleutherococcus extract on the induction of recessive lethal mutations by cyclophosphane and N-nitrosomorpholine in Drosophila. Khim-Farm Zh 19:539–540

    Google Scholar 

  42. Gvamichava AR, Khatiashvili TM, Khudzhadze RG et al. (1966) First results of the use of Eleutherococcus in the combined treatment of breast carcinoma. Lek Sredestva Dal’nego Vostoka 7:231–235

    Google Scholar 

  43. Dalinger OI (1986) The effect of an extract of Eleutherococcus on the cardiovascular system and some measures of the ability to work of older persons. Central nervous stimulants — Tomsk: 112–114

    Google Scholar 

  44. Mikaelyan EM, Mkhitaryan VG (1986) Antioxidant properties of Eleutherococcus. Biol Zh Arm 39:593–597

    Google Scholar 

  45. Barenboim GM, Sterlina AG, Bebyakova NV et al. (1986) Investigation of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. VIII. Investigation of natural killer activation by the Eleutherococcus extract. Khim-Farm Zh 28:914–917

    Google Scholar 

  46. Moskalik KG (1973) Change in the functional state of the reticulo-endothelial system and the phagocytic activity of blood leukocytes in rats with Pliss lymphosarcoma in the postoperative state under the effect of some adaptogens. Oncologiya, Kiev 4:170–173

    CAS  Google Scholar 

  47. Stukov AN (1966) Combined action of Eleutherococcus senticosus and sarcolysin on lymphosarcoma LIO-I in mice. Vopr Oncol 12:57–60

    Google Scholar 

  48. Barkan AI, Gaiduchenya LI, Makarenko YA (1980) Effect of Eleutherococcus on the morbidity of viral respiratory infections among children in organized collectives. Pediatry a (Moscow) 4:65–66

    Google Scholar 

  49. Khatiashvili TM (1968) Experimental use of fluid extract from Eleutherococcus in combined treatment of patients with carcinoma of the lip and oral cavity. B.A./RRM 6:7572

    Google Scholar 

  50. Kupin VI, Polevaya EV, Sorokin AM (1986) Use of Eleutherococcal extract to increase immunological reactivity in oncological patients. Vop Oncol (Leningrad) 32:21–26

    CAS  Google Scholar 

  51. Lyubomudrov VE, Fidel’man VG, Shikanov ME, Vankhanen GA (1971) Treatment of miners with chronic bronchitis. Vrach Delo 10:66–69

    Google Scholar 

  52. Lyubomudrov VE, Osadchuk VS, Shikanov ME, Vankhanen GA (1972) Acceleration of acclimatization in sanatorium climato-therapy of miners with chronic bronchitis and pneumoconiosis. Vopr Kurortol Fizioter Lech Fiz Kul’t 37:130–132

    Google Scholar 

  53. Vereshchagin IA, Geskina OD, Bukhteeva RR (1982) Increasing of antibiotic therapy efficacy with adaptogens in children suffering from dysentery and Proteus infections. Antibiotiki 27:65–69

    PubMed  CAS  Google Scholar 

  54. Bohn B, Nebe CT, Birr C (1987) Flow-cytometric studies with Eleutherococcus senticosus extract as an immunomodulatory agent. Arzneim Forsch 37:1193–1196

    CAS  Google Scholar 

  55. Hirosue T, Matsuzawa M, Kawai H et al. (1986) Mutagenicity and subacute toxicity of Acanthopanax senticosus extracts in rats. J Food Hyg Soc Jpn 27:380–386

    Article  CAS  Google Scholar 

  56. Medon PJ, Thompson EB, Farnsworth NR (1981) Hypoglycemic effect and toxicity of Eleutherococcus senticosus following acute and chronic administration in mice. Acta Pharmacol Sin 2:281–285

    CAS  Google Scholar 

  57. Dardymov IV, Suprunov NI, Sokolenko LA (1972) Absence of toxicity of Eleutherococcus glycosides during administration for two months. Lek Sredestva Dal’nego Vostoka 11:66–69

    CAS  Google Scholar 

  58. Golotin VG, Brekhman II, Dobryakova AI, Li SE (1972) Influence of Ginseng and Eleutherococcus extracts on life expectancy of white rats. Lek Sredestva Dal’nego Vostoka 11:37–41

    Google Scholar 

  59. Schmidt M (1984) Ginseng — Alles heilendes Wundermittel? Dtsch Apoth Ztg 124:1397–1398

    Google Scholar 

  60. Mikunis RI, Serkova VK, Shirkova TA (1966) The effect of Eleutherococcus on some biochemical parameters of the blood in the combined treatment of patients with rheumatic lesions of the heart. Lek Sredestva Dal’nego Vostoka 7:227–230

    Google Scholar 

  61. Punnonen R, Lukola A (1980) Oestrogen-like effect of ginseng. Brit Med J 281:1110

    Article  PubMed  CAS  Google Scholar 

  62. Pearce PT, Zois I, Wynne KN, Funder JW (1982) Panax ginseng and Eleutherococcus senticosus extracts — in vitro studies on binding to steroid receptors. Endocrinol Jpn 29:567–573

    Article  PubMed  CAS  Google Scholar 

  63. Hikino H, Takahashi M, Otake K, Konno C (1986) Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G: glycans of Eleutherococcus senticosus roots. J Nat Prod 49:293–297

    Article  PubMed  CAS  Google Scholar 

  64. Medon PJ, Ferguson PW, Watson CF (1984) Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo and in vitro. J Ethnopharmacol 10:235–241

    Article  PubMed  CAS  Google Scholar 

  65. Koren G, Randor S, Martin S, Danneman D (1990) Maternal ginseng use associated with neonatal androgenization. JAMA 264:2866

    Article  PubMed  CAS  Google Scholar 

  66. Koren G (1991) Maternal use of ginseng and neonatal androgenization. JAMA 265:1828

    Article  Google Scholar 

  67. Awang DVC (1991) Maternal use of ginseng and neonatal androgenization. JAMA 265:1828

    Article  Google Scholar 

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Sonnenbora, U., Hänsel, R. (1993). Eleutherococcus Senticosus. In: De Smet, P.A.G.M., Keller, K., Hänsel, R., Chandler, R.F. (eds) Adverse Effects of Herbal Drugs 2. Adverse Effects of Herbal Drugs, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48906-8_12

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  • DOI: https://doi.org/10.1007/978-3-642-48906-8_12

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