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Aminoxyl Radicals as MRI Contrast Agents

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Bioactive Spin Labels

Abstract

Aminoxyl radicals have been suggested as potential MRI contrast agents for the last 10 years (1) but no clinically accepted examples for human applications have been approved to date. The following questions appear to need evaluation: (a) advantages of aminoxyl radicals as contrast agents in comparison to other chemical agents currently available; (b) toxicity and ways to ameliorate this property; (c) factors which influence biological lifetimes with suggested improvements; (d) versatility through derivatization; (e) pharmacologic properties as compared to other chemical contrast agents.

This is paper #010 supported from the University of Guelph MRI Facility budget

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Author information

Authors and Affiliations

  1. Departments of Clinical Studies and Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada, N1G 2W1

    Edward G. Janzen

  2. Magnetic Resonance Imaging Facility, University of Guelph, Guelph, Ontario, Canada, N1G 2W1

    Rheal A. Towner

Authors
  1. Edward G. Janzen
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  2. Rheal A. Towner
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Editors and Affiliations

  1. Gene Therapeutics Laboratory, Institute for Biotechnology, Nauchnyi Proezd., 8, 117 246, Moscow, Russia

    Renat I. Zhdanov

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© 1992 Springer-Verlag Berlin, Heidelberg

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Janzen, E.G., Towner, R.A. (1992). Aminoxyl Radicals as MRI Contrast Agents. In: Zhdanov, R.I. (eds) Bioactive Spin Labels. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48724-8_24

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  • DOI: https://doi.org/10.1007/978-3-642-48724-8_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-48726-2

  • Online ISBN: 978-3-642-48724-8

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