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Cytokines in Hemopoiesis, Oncology, and AIDS II pp 19–25Cite as

Physicochemical and Pharmacological Characterization of Interleukin-4: Implications for Clinical Utility

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Abstract

Interleukin 4 (IL-4) is a T-cell derived lymphokine that was first described in the murine system as a factor that could costimulate the growth and differentiation of B lymphocytes, but it has subsequently been demonstrated to exhibit pleiotropic effects on various cell types (see [1–3] for reviews). However, detailed characterization of the pharmacological and physicochemical properties of IL-4 has been difficult due to the extremely small quantities available from natural sources. The isolation of cDNA clones for both murine and human IL-4 has permitted the expression of recombinant IL-4 in various types of hosts and subsequent large-scale production of the recombinant cytokines [4, 5]. Similar to its murine analog, recombinant human IL-4 (rhulL-4) has demonstrated pleiotropic effects on both hematopoietic and nonhematopoietic cells and, based on its interesting biological properties, is currently being evaluated in clinical trials in a variety of indications

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Authors
  1. P. P. Trotta
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Editors and Affiliations

  1. Abteilung Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    Mathias Freund  & Hartmut Link  & 

  2. Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    Reinhold E. Schmidt

  3. Abteilung Pädiatrische Hämatologie und Onkologie, Kinderklinik, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    Karl Welte

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© 1992 Springer-Verlag, Berlin Heidelberg

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Trotta, P.P. (1992). Physicochemical and Pharmacological Characterization of Interleukin-4: Implications for Clinical Utility. In: Freund, M., Link, H., Schmidt, R.E., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48715-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-48715-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55242-0

  • Online ISBN: 978-3-642-48715-6

  • eBook Packages: Springer Book Archive

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