Abstract
Cytokines constitute a class of soluble small proteins which previously have been designated monokines, lymphokines, or interleukins. They represent the intercellular signaling system for hematopoiesis and immune reactions. During the last 10 years 20 or more cytokine genes have been cloned. This allowed their careful characterization in a number of different regards. Cytokines regulate hematopoietic cell differentiation and proliferation and determine intensity and duration of immune reactions. The common characteristic feature of cytokines is that they are pleiotropic, that different cytokines may have redundant activities, and that they form a complex, poorly understood network in vivo. Depending on the experimental situation and on the cytokine which is analyzed, cytokines may have both deleterious and beneficial consequences for tumor cell growth.
This work was supported by the Deutsche Forschungsgemeinschaft (B1 288/1-1).
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© 1992 Springer-Verlag, Berlin Heidelberg
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Dorsch, M., Diamantstein, T., Blankenstein, T. (1992). Cytokine Involvement in Tumor Development and Tumor Suppression. In: Freund, M., Link, H., Schmidt, R.E., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48715-6_12
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DOI: https://doi.org/10.1007/978-3-642-48715-6_12
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