Abstract
Magnetic resonance imaging (MRI) is most sensitive in detecting intracranial tumors but lacks specificity concerning histopathology and the malignant versus benign nature of the lesion. Since in vivo magnetic resonance spectroscopy (MRS) became available, several experimental and clinical investigations have suggested that MRS provides useful information for biochemical tumor characterization (Tanaka et al. 1986; Heindel et al. 1988; Bruhn et al. 1989; Gill et al. 1990). Monitoring of therapy effects (Naruse et al. 1986; Segebarth et al. 1987) may become an even more important application of MRS. The purpose of this study was to evaluate the clinical value of MRS for the diagnosis of low- and high-grade gliomas.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bruhn H, Frahm J, Gyngell ML et al. (1989) Noninvasive differentiation of tumors with use of localized H-1 MR spectroscopy in vivo: initial experiences in patients with cerebral tumors. Radiology 172: 541–548
Demaerel P, Johannik K, van Hecke Pet al. (1991) Localized 1H NMR spectroscopy in fifty cases of newly diagnosed intracranial tumors. J Comput Assist Tomogr 15 /1: 67–76
Frahm J, Bruhn H, Gyngell ML et al. (1989) Localized high resolution H-1-NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo. Magn Reson Med 9: 79–93
Gill SS, Thomas DGT, Van Bruggen N et al. (1990) Proton MR-spectroscopy of intracranial tumors: in vivo and in vitro studies. J Comput Assist Tomogr 14 /4: 497–504
Heindel, W, Bunke J, Glathe S et al. (1988) Combined 1H-MR imaging and localized 31-P spectroscopy of intracranial tumors in 43 patients. J Comput Assist Tomogr 12 /6: 907–916
Jeske J, Herholz K, Heinckl W et al (1989) Stoffwechseluntersuchungen an Gliomen mit der Positronen-Emissiiounstomographie and der Phosphor 31-MR Spektroskopie in Diagnostik and Therapieplanung. Onkologie 12: 42–45
Koller KJ, Zaczek R, Coyle JT (1984) N-Acetyl-aspartate-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method. J Neurochem 43: 1136–1142
Naruse S, Horikawa Y, Tanaka C (1986) Evaluation of the effects of photoradiation therapy on brain tumors with in vivo P-31 MR spectrscopy. Radiology 160: 827–830
Segebarth C, Baleriaux D, Arnold D (1987) MR-image-guided P31 MR spectroscopy in the evaluation of brain tumor treatment. Radiology 165: 215–219
Tanaka C, Naruse S, Horikawa Y et al. (1986) Proton nuclear magnetic resonance spectra of brain tumors. Magn Reson Imaging 4: 503–508
Zülch KJ (1980) Principles of the new World Health Organization (WHO) classification of brain tumors. Neuroradiology 19: 59–66
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Felber, S.R., Stockhammer, G.J., Birbamer, G.G., Kostron, H., Aichner, F.T. (1992). Nuclear Magnetic Resonance Spectroscopy of Low- and High-Grade Human Gliomas. In: Breit, A., Heuck, A., Lukas, P., Kneschaurek, P., Mayr, M. (eds) Tumor Response Monitoring and Treatment Planning. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48681-4_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-48681-4_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-54783-9
Online ISBN: 978-3-642-48681-4
eBook Packages: Springer Book Archive