Abstract
Late effects are essential concomitants in clinical radiotherapy of malignant diseases. Generally these are typical for normal tissues and organs with flexible nonhierarchical structure and a relatively low proliferative activity and consequently consist preferentially of functional cells. In terms of the widely used linear-quadratic (LQ) model, late effects correspond to low α/β ratios, and the incidence and latency times of these effects show a strong dependence on possible changes in the fractionation regime. The α/β ratio of the lung (humans and experimental animals) with respect to the radiation-induced pneumonitis reaction is low and has been determined to be 3–4 Gy. Thus, the lung is a typical late-reacting organ. Indeed, the pneumonitis reaction as one of the most severe side effects of irradiations of the thoracic region appears some months after the end of treatment. Therefore it is highly desirable to have reliable mathematical and statistical methods to analyze clinical and experimental data and to predict the complication rate and mean latency time of the side effects in cases of new schedules. This is an essential precondition for the determination of optimal fractionation schedules in tumor treatment having the lung as dose-limiting organ.
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References
Bentzen SM, Thames HD, Travis EL, Ang KK, van der Schueren E, Dewit L, Dixon DO (1989) Direct estimation of latent time for radiation injury in late-responding normal tissues: gut, lung, and spinal cord. Int J Radiat Biol 55: 27–43
Collis CH (1982) A kinetic model for the pathogenesis of radiation lung damage. Int J Radiat Biol 42: 253–263
Cox DR (1972) Regression models and life-tables. J R Statist Soc [B] 34: 187–220
Dale RG (1985) The application of the linear-quadratic dose-effect equation to fractionated and protracted radiotherapy. Br J Radiol 58: 515–528
Taylor JMG, Withers HR, Vegesna V, Mason K (1987) Fitting the linear-quadratic model using time of occurrence as the endpoint for quantal response experiments. Int J Radiat Biol 52: 459–468
Thames HD (1985) An “incomplete-repair” model for survival after fractionated and continuous irradiations. Int J Radiat Biol 47: 319–339
Vegesna V, Withers HR, Thames HD, Mason KA (1986) Multifraction radiation response of mouse lung. Int J Radiat Biol 47: 413–427
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© 1992 Springer-Verlag Berlin Heidelberg
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Schmidt, W., Merkle, K. (1992). Biphasic Repair and Prediction of Late Effects Following Lung Irradiation. In: Breit, A., Heuck, A., Lukas, P., Kneschaurek, P., Mayr, M. (eds) Tumor Response Monitoring and Treatment Planning. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48681-4_27
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DOI: https://doi.org/10.1007/978-3-642-48681-4_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-54783-9
Online ISBN: 978-3-642-48681-4
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