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Influence of Liposomal Encapsulation on the Activity of a Herbal Non-steroidal Anti-Inflammatory Drug

  • Conference paper
Liposome Dermatics

Part of the book series: Griesbach Conference ((GRIESBACH))

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Abstract

Currently there are two main principles for the topical treatment of inflammatory dermatoses. First there are topical glucocorticoids [5] and second there are non-steroidal anti-inflammatory dermatics, e.g. bufexamac, chamomile extract and hamamelis destillate [2, 25]. In recent years there was an increase in the efficacy of topical glucocorticoids due to the introduction of new compounds. Yet, in parallel, there was an increase in unwanted effects, e.g. atrophy of the skin treated and suppression of the hypothalamic-pitui-tary-adrenal axis [5].

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References

  1. Aertgeerts J (1984) Erfahrungen mit Kamillosan R, einem standardisierten Kamilleextrakt in der dermatologischen Praxis. Ärztl Kosmetol 14:502–504

    Google Scholar 

  2. Aertgeerts J, Albring M, Klaschka F, Nasemann Th, Patzelt-Wenczler R, Rauhut K, Weigl B (1985) Vergleichende Prüfung von Kamillosan R Creme gegenüber steroidalen (0.25% Hydrocortison, 0.75% Fluocortinbutylester) und nicht-steroidalen (5% Bufexamac) Externa in der Erhaltungstherapie von Ekzemerkrankungen. Zeitschr Hautkr 60:270–277

    CAS  Google Scholar 

  3. Agner T (1991) Basal transepidermal water loss, skin thickness, skin blood flow and skin colour in relation to sodium-laurylsulphate-induced irritation in normal skin. Contact Derm 25:108–114

    Article  PubMed  CAS  Google Scholar 

  4. Albring M, Albrecht H, Alcorn G, Lücker PW (1983) The measuring of the antiinflammatory effect of a compound on the skin of volunteers. Meth and Find Clin Pharmacol 5:575–577

    CAS  Google Scholar 

  5. Bateman DN (1989) Clinical pharmacology of topical steroids. In: Greaves MW et al (eds) Pharmacology of the Skin II. Springer, Berlin, pp 239–249

    Chapter  Google Scholar 

  6. Delia Loggia R, Tubaro A, Dri P, Zilli C, Del Negro P (1986) The role of flavonoids in the antiinflammatory activity of Chamomila recutita. Progr Clin Biol Res 213:481–484

    Google Scholar 

  7. Egbaria K, Ramachandran C, Weiner N (1990) Topical delivery of Ciclosporin: Evaluation of various formulations using in vitro diffusion studies in hairless mouse skin. Skin Pharmacol 3:21–28

    Article  PubMed  CAS  Google Scholar 

  8. Egbaria K, Ramachandran C, Weiner N (1991) Topical application of liposomally entrapped Ciclosporin evaluated by in vitro diffusion studies with human skin. Skin Pharmacol 4:21–28

    Article  PubMed  CAS  Google Scholar 

  9. Egbaria K, Weiner N (1990) Liposomes as a topical drug delivery system. Adv Drug Deliv Rev 5:287–300

    Article  CAS  Google Scholar 

  10. Farr PM, Diffey BL (1984) Quantitative studies on cutaneous erythema induced by ultraviolet radiation. Brit J Dermatol 11:673–682

    Article  Google Scholar 

  11. Foldvari M, Gesztes A, Mezei M (1990) Dermal drug delivery by liposome encapsulation: Clinical and electron microscopic studies. J Microencapsulation 7:479–489

    Article  PubMed  CAS  Google Scholar 

  12. Habersang S, Leuschner F, Isaac Q, Thiemer K (1979) Pharmakologische Untersuchungen von Kamillen-Inhaltsstoffen. Untersuchungen zur Toxizität des (−)alpha Bisabolols. J Med Plant Res 37:115–123

    Article  CAS  Google Scholar 

  13. Hausen BM, Busker E, Carle R (1984) Über das Sensibilisierungsvermögen von Compositenarten. J Med Plant Res 3:205–284

    Google Scholar 

  14. Imokawa G, Akasaki S, Minematsu Y, Kawai M (1989) Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skin. Arch Dermatol Res 281:45–51

    Article  PubMed  CAS  Google Scholar 

  15. Kadir R, Barry BW (1991) Alpha-Bisabolol, a possible safe penetration enhancer for dermal and transdermal therapeutics. Int J Pharm 70:87–94

    Article  CAS  Google Scholar 

  16. Kaidbey KH, Kligman AM (1974) Assay of topical corticosteroids by suppression of experimental inflammation in humans. J Invest Dermatol 63:292–297

    Article  PubMed  CAS  Google Scholar 

  17. Korting HC, Zienicke H, Schäfer-Körting M, Braun-Falco O (1990) Liposome enca-pulsation improves efficacy of betamethasone diproprionate in atopic eczema but not in psoriasis vulgaris. Eur J Clin Pharmacol 39:349–351

    Article  PubMed  CAS  Google Scholar 

  18. Ljunggren B, Möller H (1973) Influence of corticosteroids on ultraviolet light erythema and pigmentation in man. Arch Dermatol Forsch 248:1–12

    Article  PubMed  CAS  Google Scholar 

  19. Mahjour M, Mauser B, Rashidbaighi Z, Fawzi MB (1990) Effect of egg yolk lecithins and commercial soybean lecithins on in vitro skin permeation of drugs. J Controlled Release 14:243–252

    Article  CAS  Google Scholar 

  20. Mc Kenzie SW, Stoughton RB (1962) Method for comparing percutaneous absorption of steroids. Arch Dermatol 86:608–610

    Article  Google Scholar 

  21. Mezei M, Gulasekharam V (1980) Liposomes — a selective drug delivery system for the topical route of administration. Life Sci 26:1473–1477

    Article  PubMed  CAS  Google Scholar 

  22. Niedner R, Johannböcke R (1991) Ausgewählte humanpharmakologische Modelle zur Untersuchung topischer Glukokortikoide. TW Dermatol 21:298–306

    Google Scholar 

  23. Nissen HP, Biltz H, Kreysel HW (1988) Pronlometrie, eine Methode zur Beurteilung der therapeutischen Wirksamkeit von Kamillosan Salbe. Zeitschr Hautkr 63:184–190

    CAS  Google Scholar 

  24. Schäfer-Korting M, Korting HC, Braun-Falco O (1989) Liposome preparations: A step forward in topical drug therapy for skin disease? J Am Acad Dermatol 21:1271–1275

    Article  PubMed  Google Scholar 

  25. Swoboda M, Meurer J (1991) Therapie von Neurodermitis mit Hamamelis-virginiana-Extrakt in Salbenform. Zeitschr Phytother 12:114–117

    Google Scholar 

  26. Wells GC (1957) The effect of hydrocortisone on standardized skin surface trauma. Brit J Dermatol 69:11–18

    Article  CAS  Google Scholar 

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© 1992 Springer-Verlag Berlin Heidelberg

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Kerscher, M.J. (1992). Influence of Liposomal Encapsulation on the Activity of a Herbal Non-steroidal Anti-Inflammatory Drug. In: Braun-Falco, O., Korting, H.C., Maibach, H.I. (eds) Liposome Dermatics. Griesbach Conference. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48391-2_35

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  • DOI: https://doi.org/10.1007/978-3-642-48391-2_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55646-6

  • Online ISBN: 978-3-642-48391-2

  • eBook Packages: Springer Book Archive

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