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Fibrin Sealant: Efficacy, Quality, and Safety

  • Conference paper
Progress in Fibrin Sealing

Abstract

Today fibrin sealing is an accepted method in operative medicine, known all over the world, and there are still new indications emerging for it. The ultimate method of fibrin sealing has certainly not yet been determined, and there are many questions regarding its efficacy (and the improvement of its efficacy), its quality (which is decisive for an undelayed healing process), and its safety (i.e., exclusion of the transmission of viral infections). For these reasons research is still being carried on, and new experiences are to be expected in the future, in particular in terms of wound healing.

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References

  1. Spängier HP, Braun F, Holle J, Moritz E, Wolner E (1976) Die lokale Anwendung von Fibrinogen und Kollagen zur Blutstillung in der Herzchirurgie. Wien Med Wochenschr 126:86–89

    Google Scholar 

  2. Haverich A, Borst HG (1980) Fibrin glue for treatment of bleeding in cardiac surgery. In: Bircks W, Ostermeyer J, Schulte HD (eds) Cardiovascular surgery 1980. Springer, Berlin Heidelberg New York, pp 621–624

    Google Scholar 

  3. Borst HG (1981) Replacement of ascending aorta and aortic valve. Ann Thorac Surg 32:613–615

    Article  PubMed  CAS  Google Scholar 

  4. Borst HG, Haverich A, Walterbusch G, Maatz W (1982) Fibrin adhesive: an important hemostatic adjunct in cardiovascular operations. J Thorac Cardiovasc Surg 84:548–553

    PubMed  CAS  Google Scholar 

  5. Haverich A, Walterbusch G, Borst HG (1981) The use of fibrin glue for sealing vascular prosthesis of high porosity. Thorac Cardiovasc Surg 29:252–254

    Article  PubMed  CAS  Google Scholar 

  6. Haverich A, Maatz W, Walterbusch G (1982) Evaluation of fibrin seal in animal experiments. Thorac Cardiovasc Surg 30:215–222

    Article  PubMed  CAS  Google Scholar 

  7. Walterbusch G, Haverich A, Borst HG (1982) Clinical experience with fibrin glue for local bleeding control and sealing of vascular prostheses. Thorac Cardiovasc Surg 30:234–235

    Article  PubMed  CAS  Google Scholar 

  8. Haverich A, Wahlers T, Walterbusch G, Borst HG (1986) The use of fibrin sealant and fibrin sealant combined with antibiotics in cardiovascular surgery. In: Schlag G, Redl H (eds) Fibrin sealant in operative medicine, vol 5. Thoracic surgery, cardiovascular surgery. Springer, Berlin Heidelberg New York, pp 185–190

    Google Scholar 

  9. Huth C, Seybold-Epting W, Hoffmeister HE (1983) Local hemostasis with fibrin glue after intracardiac repair of tetralogy of Fallot and transposition of the great arteries. Thorac Cardiovasc Surg 31:142–146

    Article  PubMed  CAS  Google Scholar 

  10. Huth C, Hoffmeister HE (1986) Use of fibrin glue (Tissucol/Tisseel) to achieve hemostasis in patches and suture lines in surgical repair of congenital heart defects. In: Schlag G, Redl H (eds) Fibrin sealant in operative medicine, vol 5. Thoracic surgery, cardiovascular surgery. Springer, Berlin Heidelberg New York, pp 164–175

    Google Scholar 

  11. Rousou J, Levitsky S, Gonzalez-Lavin L, Cosgrove D, Magilligan D, Weldon C, Hiebert C, Hess P, Joyce L, Bergland J, Gazzaniga A (1988) Randomized clinical trial of Tisseel — two-component fibrin sealant in cardiac surgery patients undergoing resternotomy or reoperation — a multicenter study. Symposium on Tisseel — two-component fibrin sealant in cardiothoracic surgey, 18 April 1988, Los Angeles

    Google Scholar 

  12. Gasser G, Mossig H, Fischer M, Eidler R, Kläring W, Lurf H (1983) Modifikation der suprapubischen Prostatektomie unter Verwendung eines biologischen Klebeverfahrens. Wien Klin Wochenschr 95:399–403

    PubMed  CAS  Google Scholar 

  13. Vecsey D (1980) Über eine neue Methode der Blutstillung mit Klebematerial bei der Adenomektomie. Z Urol Nephrol 1:57–62

    Google Scholar 

  14. Vecsey D (1988) Prevention of early complications associated with the operation of bladder neck adenoma (prostatic hyperplasia). Orv Hetil 129:871–876

    PubMed  CAS  Google Scholar 

  15. Guttmann J (1979) Untersuchung eines Fibrinklebers für die Anwendung in der Chirurgie peripherer Nerven. Dissertation, Technical University of Vienna

    Google Scholar 

  16. Seelich T, Redl H (1980) Theoretische Grundlagen des Fibrinklebers. In: Schimpf K (ed) Fibrinogen, Fibrin und Fibrinkleber. Schattauer, Stuttgart, pp 199–208

    Google Scholar 

  17. Redl H, Stanek G, Hirschl A, Schlag G (1982) Fibrinkleber-Antibiotika-Gemische — Festigkeit und Elutionsverhalten. In: Cotta H, Braun A (eds) Fibrinkleber in Orthopädie und Traumatologie. Thieme, Stuttgart, pp 18–21

    Google Scholar 

  18. Redl H, Schlag G, Stanek G, Hirschl A, Seelich T (1983) In vitro properties of mixtures of fibrin seal and antibiotics. Biomaterials 4:29–32

    Article  PubMed  CAS  Google Scholar 

  19. Duckert F, Nyman D, Gastpar H (1978) Factor XIII fibrin and collagen. Coll platelet interact. Schattauer, Stuttgart, pp 391–396

    Google Scholar 

  20. Bäumer F, Bader A, Keller F, Henrich HA (1988) Flüssigkeits- und Eiweißbilanz bei III.-gradigen Verbrennungen. In: Zellner PR (ed) Fibrinklebung in der Verbrennungschirurgie — Plastischen Chirurgie. Springer, Berlin Heidelberg New York, pp 31–36

    Chapter  Google Scholar 

  21. Eckersley JRT, Dudley HAF (1988) Wounds and wound healing. Br Med Bull 44:423–436

    PubMed  CAS  Google Scholar 

  22. Wokalek H (1988) Cellular events in wound healing. CRC Crit Rev Biocompatibil 4:209–246

    CAS  Google Scholar 

  23. Brown LF, van de Water L, Harvey VS, Dvorak HF (1988) Fibrinogen influx and accumulation of cross-linked fibrin in healing wounds and in tumor stroma. Am J Pathol 130:455–465

    PubMed  CAS  Google Scholar 

  24. Dvorak HF, Harvey VS, Estrella P, Brown LF, McDonagh J, Dvorak AM (1987) Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. Lab Invest 57:673–686

    PubMed  CAS  Google Scholar 

  25. Peacock EE (1984) Inflammation and the cellular response to injury. In: Wound repair, 3rd edn. Saunders, Philadelphia, pp 1–14

    Google Scholar 

  26. Knighton DR, Hunt TK, Scheuenstuhl H, Halliday B, Werb Z, Banda M (1983) Oxygen tension regulates the expression of angiogenesis factor by macrophages. Science 221:1283–1285

    Article  PubMed  CAS  Google Scholar 

  27. Diegelmann RF, Kim JC, Lindblad WJ, Smith TC, Harris TM, Cohen IK (1987) Collection of leukocytes, fibroblasts, and collagen within an implantable reservoir tube during tissue repair. J Leukocyte Biol 42:667–672

    PubMed  CAS  Google Scholar 

  28. Kehrl JH, Wakefield LM, Roberts AB, Jakowlew S, Alvarez-Mon M, Derynck R, Sporn MB, Fauci AS (1986) Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med 163:1037–1050

    Article  PubMed  CAS  Google Scholar 

  29. Sporn MB, Roberts AB, Wakefield LM, Assoian RK (1986) Transforming growth factor beta: biological function and chemical structure. Science 233:532–534

    Article  PubMed  CAS  Google Scholar 

  30. Brändstedt S, Olson PS (1980) Effect of defibrinogenation on wound strength and collagen formation. A study in the rabbit. Acta Chir Scand 146:483–486

    PubMed  Google Scholar 

  31. Brändstedt S, Olson PS (1981) Lack of influence on collagen accumulation in granulation tissue with delayed defibrinogenation. A study in the rabbit. Acta Chir Scand 147:89–91

    PubMed  Google Scholar 

  32. Brändstedt S, Olson PS, Ahonen J (1980) Effect of defibrinogenation on collagen synthesis in granulation tissue. A study in the rabbit. Acta Chir Scand 146:551–553

    PubMed  Google Scholar 

  33. Brändstedt S, Rank F, Olson PS (1980) Wound healing and formation of granulation tissue in normal and defibrinogenated rabbits. An experimental model and histological study. Eur Surg Res 12:12–21

    Article  PubMed  Google Scholar 

  34. Brändstedt S, Rank F, Olson PS, Ahonen J (1980) Cell composition of granulation tissue in defibrinogenated rabbits. Acta Chir Scand 146:545–549

    PubMed  Google Scholar 

  35. Köstering H, Nagel GA (1980) Prophylaxe und Therapie von Zytostatika-Hautnekrosen. Onkologie 3:3–6

    Article  Google Scholar 

  36. Wieding JU, Merten HA, Köstering H (1987) Applikation von Fibrinogen und Fibrin bei Störungen der primären Wundheilung. Med Welt 38:581–587

    Google Scholar 

  37. Bäumer F, Bader A, Henrich HA, Buchmann F (1987) Zum Stellenwert der Applikation von Fibrinkleber bei der chirurgischen Behandlung ausgedehnter Wundflächen. Med Welt 38:1258–1261

    Google Scholar 

  38. Grabosch A, Fisseler-Eckhoff A (1988) Fibrinklebung zur Versorgung von Brandwunden — Klinische und histologische Untersuchungen. In: Zellner PR (ed) Fibrinklebung in der Verbrennungschirurgie — Plastischen Chirurgie. Springer, Berlin Heidelberg New York, pp 31–36

    Google Scholar 

  39. Fisseler-Eckhoff A, Grabosch A, Donati I, Müller KM (1988) Histologische Untersuchungsergebnisse nach Hauttransplantation mit und ohne Fibrinkleber. Ellipse 15:180–186

    Google Scholar 

  40. Schlag G, Redl H, Turnher M, Dinges HP (1986) The importance of fibrin in wound repair. In: Schlag G, Redl H (eds) Fibrin sealant in operative medicine, vol 2. Ophthalmology, neurosurgery. Springer, Berlin Heidelberg New York, pp 3–12

    Chapter  Google Scholar 

  41. Beck E, Duckert F, Vogel A, Ernst M (1962) Der Einfluß des fibrinstabilisierenden Faktors (FSF) auf Funktion und Morphologie von Fibroblasten in vitro. Z Zellforsch Mikrosk Anat 57:327–346

    Article  PubMed  CAS  Google Scholar 

  42. Bruhn HD, Christophers E, Pohl J, Schoel G (1979) Regulation der Fibroblastenproliferation durch Fibrinogen/Fibrin, kälteunlösliches Globulin und Faktor XIII. Blut 38:65

    Google Scholar 

  43. Turowski G, Schaadt M, Bartheis M, Diehl V, Poliwode H (1979) Unterschiedlicher Einfluß von Fibrinogen und Faktor XIII auf das Wachstum von Primär- und Kulturfibroblasten. Blut 38:65

    Google Scholar 

  44. Blümel G, Ascherl R, Geissdörfer K, Schäfer G (1988) Experimentelle Untersuchungen zur Fibrinklebung bei Verbrennungswunden. In: Zellner PR (ed) Fibrinklebung in der Verbrennungschirurgie — Plastischen Chirurgie. Springer, Berlin Heidelberg New York, pp 25–30

    Chapter  Google Scholar 

  45. Henrich HA, Bäumer F, Oberschelp J, Kilian K (1988) Einfluß von drei verschiedenen Gewebeklebern auf Vollhauttransplantate bei Verbrennungen. Med Welt 39:701–706

    Google Scholar 

  46. Ferry JD, Morrison PR (1947) Preparation and properties of serum and plasma proteins. VIII. The conversion of human fibrinogen to fibrin under various conditions. J Am Chem Soc 69:388–400

    Article  PubMed  CAS  Google Scholar 

  47. Redl H, Schlag G, Dinges HP (1985) Vergleich zweier Fibrinkleber. Einfluß ionischer Zusätze auf Fibrinstruktur sowie Morphologie und Wachstum menschlicher Fibroblasten. Med Welt 36:769–776

    CAS  Google Scholar 

  48. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63

    Article  PubMed  CAS  Google Scholar 

  49. Lambrecht JT, Klinger M (1988) Resorption von Fibrinkleber durch isolierte Knochenzellen in der Kultur. Med Welt 39:493–496

    Google Scholar 

  50. Harmand MF, Michel D, Bagot d’Arc M (1986) Effects of fibrin seals on human fibroblast attachment and multiplication. In: Proceedings of European congress on biomaterials, Bologna

    Google Scholar 

  51. Seelich T (1988) A propos des critères de qualité d’une colle biologique. Lyon Chir 84:259–260

    Google Scholar 

  52. Burnouf-Radosevich M, Duval P, Burnouf T, Huart JJ (1988) Composition protéique et qualité de colles biologiques européennes. Lyon Chir 84:191–195

    Google Scholar 

  53. Scheele J, Schricker KT, Goy D, Lampe I, Panis R (1981) Hepatitisrisiko der Fibrinklebung in der Allgemeinchirurgie. Med Welt 32:783–788

    PubMed  CAS  Google Scholar 

  54. Panis R, Scheele J (1981) Hepatitisrisiko bei der Fibrinklebung in der HNO-Chirurgie. Laryngol Rhinol Otol 60:367–368

    Article  CAS  Google Scholar 

  55. Eder G, Neumann M, Cerwenka R, Baumgarten K (1986) Preliminary results of a randomized controlled study on the risk of hepatitis transmission of a two-component fibrin sealant (Tissucol/Tisseel). In: Schlag G, Redl H (eds) Fibrin sealant in operative medicine, vol 2. Ophthalmology, neurosurgery. Springer, Berlin Heidelberg New York, pp 51–59

    Chapter  Google Scholar 

  56. Grasgrove D (1988) Tissel-Two-Component Fibrin Sealant in Reoperative Cardiovascular Surgery — The Cleveland Clinic Experience. Symposium as Tissel — Two component fibrin sealant in cardiothoracic surgery, 18 April 1988, Los Angeles

    Google Scholar 

  57. Petricciani JC, McDougal JS, Evatt BL (1985) Case for concluding that heat-treated licenced anti-haemophilic factor is free from HTLV-III. Lancet ii:890–891

    Article  Google Scholar 

  58. Dinges HP, Redl H, Thurnher M, Schießer A, Schlag G (1986) Morphometric studies on wound healing after systemic administration of adriamycin and local application of fibrin sealant. Application of a new wound healing model using spongiosa implants. Pathol Res Pract 181:746–754

    Article  PubMed  CAS  Google Scholar 

  59. Redl H, Schlag G (1986) Properties of different tissue sealants with special emphasis of fibrinogen-based preparations. In: Schlag G, Redl H (eds) Fibrin sealant in operative medicine. Springer, Berlin Heidelberg New York, pp 27–38

    Chapter  Google Scholar 

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Authors
  1. G. Schlag
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  2. H. Redl
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Editors and Affiliations

  1. 1. Chirurgische Abteilung, Landeskrankenanstalten Salzburg, Müllner Hauptstraße 48, A-5020, Salzburg, Austria

    Hans-Werner Waclawiczek

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© 1989 Springer-Verlag Berlin Heidelberg

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Schlag, G., Redl, H. (1989). Fibrin Sealant: Efficacy, Quality, and Safety. In: Waclawiczek, HW. (eds) Progress in Fibrin Sealing. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48362-2_1

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  • DOI: https://doi.org/10.1007/978-3-642-48362-2_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50797-0

  • Online ISBN: 978-3-642-48362-2

  • eBook Packages: Springer Book Archive

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