MSD, Minimal Steric Difference (Simple Version)

Abstract

It is obvious that steric fit depends on the shape of both the biological receptor and the effector molecule. Steric parameters described in the previous chapters rely only on the shape of the effector molecule. The regressional equation will indicate if the receptor prefers large or small values for the corresponding parameter (for example van der Waals volume of the substituent or molecule, width, length, branchedness etc,); at most the optimal value of the shape characteristic corresponding to the steric parameter is indicated.