Abstract
The sequence of events occurring between one cell division and the next, i.e., during the cell generation cycle, and the relationship between these different events is of primary importance to our understanding of the proliferation process in cells and perhaps also to the distinctions between normal and malignant cells.
Work supported by the U.S. Atomic Energy Commission.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Belli, J. A.: Effect of temperature on the radiation response of synchronous mammalian cells in culture. Rad. Res. 25, 174 (1965).
Blumenthal, L. K. and Zaler, S. A.: Index for measurement of synchronization of cell populations. Science 135, 724 (1962).
Bootsma, D., Budke, L. and Vos, O.: Studies on synchronous division of tissue culture cells initiated by excess thymidine. Exp. Cell Res. 33, 301 (1964).
Burns, V. W.: Cell division synchronization. Progr. Biophysics and Biophysic. Chem. 12, 1 (1962).
Djordjevic, E. and Tolmach, L. J.: X-ray sensitivity of HeLa S3 cells in the G2 phase: Comparison of two methods of synchronization. Biophys. 7, 77 (1967).
Engleberg, J.: The decay of synchronization of cell division. Exp. Cell Res. 36, 647 (1964).
Engleberg, J.: A method of measuring the degree of synchronization of cell populations. Exp. Cell Res. 23, 218 (1961).
Erikson, R. L. and Szybalski, W.: Molecular radiobiology of human cell lines. IV. Variation in ultraviolet light and X-ray sensitivity during the division cycle. Rad. Res. 18, 200 (1963).
Kim, J. H. and Stambuk, B. K.: Synchronization of HeLa cells by vinblastine sulfate. Exp. Cell Res. 44, 631 (1966).
Kubitschek, H. E.: Discrete distributions of generation-rate. Nature 195, 350 (1962).
Littlefield, J. W.: DNA synthesis in partially synchronized L cells. Exp. Cell Res. 26, 318 (1962).
Newton, A. A. and Wildy, P.: Parasynchronous division of HeLa cells. Exp. Cell Res. 16, 724 (1959).
Petersen, D. F. and Anderson, E. C.: Quantity production of synchronized mammalian cells in suspension culture. Nature 203, 642 (1964).
Pfeiffer, S. E. and Tolmach, L. J.: Selecting synchronous populations of mammalian cells. Nature 123, 139 (1967).
Puck, T. T.: Phasing, mitotic delay and chromosomal aberrations in mammalian cells. Science 144, 565 (1964).
Robbins, E. and Marcus, P. L.: Mitotically synchronized mammalian cells: A simple method of obtaining large populations. Science 144, 1152 (1964).
Rueckert, R. R. and Mueller, G. C.: Studies on unbalanced growth in tissue culture. I. Induction and consequences of thymidine deficiency. Cancer Res. 20, 1584 (1960).
Schindler, R.: Biochemical studies of the division cycle of mammalian cells: Evidence for the premitotic period. Biochem. Pharmacol. 12, 533 (1963).
Sinclair, W. K.: Hydroxyurea: Differential lethal effects on cultured mammalian cells during the cell cycle. Science 150, 1729 (1965).
Sinclair, W. K.: Hydroxyurea: Effects on Chinese hamster cells grown in culture. Cancer Res., Part I, 297 (1967).
Sinclair, W. K. and Morton, R. A.: X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Rad. Res. 29, 450 (1966).
Sinclair, W. K. and Morton, R. A.: X-ray and ultra-violet sensitivity of synchronized Chinese hamster cells at various stages of the cell cycle. Biophys. J. 5, 1 (1965).
Sinclair, W. K. and Morton, R. A.: Variations in X-ray response during the division cycle of partially synchronized Chinese hamster cells in culture. Nature 199, 1158 (1963).
Stubblefield, E. and Klevecz, R.: Synchronization of Chinese hamster cells by reversal of colcemid inhibition. Exp. Cell Res. 40, 660 (1965).
Terasima, T. and Tolmach, L. J.: Growth and nucleic acid synthesis in synchronously dividing populations of HeLa cells. Exp. Cell Res. 30, 344 (1963).
Terasima, T. and Tolmach, L. J.: Variations in several responses in HeLa cells to X-irradiation during the division cycle. Biophys. J. 3, 11 (1963).
Till, J. E., Whitmore, G. F. and Gulyas, S.: Deoxyribonucleic acid synthesis in individual L-strain mouse cells. II. Effects of thymidine starvation. Biochim. Biophysica Acta 72, 277 (1963).
Whitfield, J. F. and Youdale, T.: Synchronization of cell division in suspension cultures of L-strain mouse cells. Exp. Cell Res. 38, 208 (1965).
Whitmore, G. F. and Gulyas, S.: Synchronization of mammalian cells with tritiated thymidine. Science 151, 691 (1966).
Xeros, N.: Deoxyriboside control and synchronization of mitosis. Nature 194, 682 (1962).
Zeuthen, E.: Artificial and induced periodicity in living cells. Advances Biol. and Med. Physics 6, 37 (1958).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1969 Springer-Verlag New York Inc.
About this chapter
Cite this chapter
Sinclair, W.K. (1969). Discussion Methods and Criteria of Mammalian Cell Synchrony. In: Fry, R.J.M., Griem, M.L., Kirsten, W.H. (eds) Normal and Malignant Cell Growth. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 17. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48263-2_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-48263-2_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-48265-6
Online ISBN: 978-3-642-48263-2
eBook Packages: Springer Book Archive