Skip to main content
SpringerLink
Log in

Heredity and the More Common Malignancies of Man: Carcinoma of the Breast, Stomach, Colon, Lung, Prostate, and Endometrium

  • Chapter
Hereditary Factors in Carcinoma

Abstract

Carcinoma of the breast, stomach, colon, lung, prostate, and endometrium represent some of the most common malignant neoplasms of man. However, in spite of their frequency, the etiology and pathogenesis of each of these malignancies remains unclear. At some time or other the pendulum has swung heavily in the direction of either a hereditary or an environmental etiology for these malignancies. However, we believe that such a nature-nurture position is unfruitful and will be shown to be untenable; specifically, we believe that when the etiologic facts are finally compiled for these malignancies, an intricate interaction of both hereditary and environmental factors will be disclosed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ackerman, L. V. and del Regato, J. A.: Cancer: Diagnosis, Treatment, and Prognosis, St. Louis: The C. V. MosbyCo., 1962.

    Google Scholar 

  2. Anderson, V. E., Goodman, N. O., and Reed, S. C.: Variables Related to Human Breast Cancer, Minneapolis: University of Minnesota Press, 1958.

    Google Scholar 

  3. Apt, A.: Circumcision and Prostatic Carcinoma, Acta Med. Scand. 178:493–504, 1965.

    Article  PubMed  CAS  Google Scholar 

  4. Ardeman, S., Chanarin, I., Jacobs, A., and Griffiths, L.: Family Study in Pernicious Anemia, Blood 27: 559–610, 1966.

    Google Scholar 

  5. Baanders, E. A., de Waard, F., Mastboom, E. T., and Meinsma, L.: Constitutional and Hereditary Aspects of Endometrial Carcinoma, Z. Geburtsh. Gynaek. 161:77–93, 1963.

    Google Scholar 

  6. Benjamin, F. and Romney, S. L.: Disturbed Carbohydrate Metabolism in Endometrial Carcinoma, Cancer 17: 386–390, 1964.

    Article  PubMed  CAS  Google Scholar 

  7. Bockus, H. L., Tachdjian, V., Ferguson, L. K., Mouhran, Y., and Chamberlain, C.: Adenomatous Polyps of Colon and Rectum: Its Relation to Carcinoma, Gastroenterology 41: 225–232, 1961.

    Google Scholar 

  8. Borrie, J.: Lung Cancer: Surgery and Survival, New York: Appleton-Century-Crofts, 1965.

    Google Scholar 

  9. Brøbeck, O.: Heredity in Cancer Uteri: A Genetical and Clinical Study of 200 Patients with Cancer of the Cervix Uteri and 90 Patients with Cancer of the Corpus Uteri, Aarhus, Denmark: Universitetsfarlaget, 1949.

    Google Scholar 

  10. Buckwalter, J. A., Wahlwend, C. B., Colter, D. C., Tidrick, R. T., and Knowler, L. A.: The Association of the ABO Blood Groups to Gastric Carcinoma, Surg. Gynec. Obstet. 104:176–179, 1957.

    PubMed  CAS  Google Scholar 

  11. Campbell, M. F.: Urology 2: 2nd Ed., W. B. Saunders, Philadelphia, 1963, 895–1862, specific citation, 1173–1175.

    Google Scholar 

  12. Ceulemans, G.: Incidence Familiale Multiple du Cancer du Rectum, J. Int. Coll. Surg. 30:649–652, 1958.

    Google Scholar 

  13. Clemmesen, J.: Statistical Studies in the Aetiology of Malignant Neoplasms, Acta Path. Microbiol. Scand. Suppl. 174:11:1–319, 1965.

    Google Scholar 

  14. Close, M. B. and Maximov, N. G.: Carcinoma of Breast in Young Girls, Arch. Surg. 91:386–389, 1965.

    Article  PubMed  CAS  Google Scholar 

  15. de Dombal, F. T., Watts, J. Mck., Watkinson, G., and Goligher, J. C.: Local Complications of Ulcerative Colitis: Stricture, Pseudopolyposis, and Carcinoma of Colon and Rectum, Brit. Med. J. 1: 442–447, 1966.

    Google Scholar 

  16. de Waard, F.: On the Aetiology of Endometrial Carcinoma, Acta Endocr. Kobenhavn. 29:279–294, 1958.

    Google Scholar 

  17. Dexems Font, S., Blay, C. C., and Alberich, P. H.: General Etiology of Endometrial Cancer, Tokoginec. Pract. 20:13–26, 1963.

    Google Scholar 

  18. Dockerty, M. B., Lovelady, S. B., and Foust, G. T.: Carcinoma of the Corpus Uteri in Young Women, Amer. J. Obstet. Gynec. 61: 966–981, 1951.

    Google Scholar 

  19. Dorn, H. F.: The Increase in Cancer of the Lung, Indust. Med. 23:253–257, 1954.

    CAS  Google Scholar 

  20. Durgal, N.: The Special Problems of Stomach Cancer in Iceland, JAMA 178: 789–798, 1961.

    Article  Google Scholar 

  21. Goren, P. A.: Genetic Interpretation of Studies on Cancer in Twins, Ann. Eugen. 8:219–232, 1937–1938.

    Article  Google Scholar 

  22. Graham, J. B.: Characteristics of Women with Various Gynecologic Cancers, Obstet. Gynec. 23:274–281, 1964.

    Google Scholar 

  23. Iglesias, R.: Hormones and Tumors 1072–1084, in Proceedings of the Second International Congress of Endocrinology, International Congress Series No. 83, Excerpto Medica Foundation, Part I I, 1964.

    Google Scholar 

  24. Incidence Symposium on Fundamental Cancer Research. 13th; Houston, Texas, 1959. Genetics and Cancer. The University of Texas, Austin, Texas, pp. 426–438.

    Google Scholar 

  25. Jackson, A. W., et al.: Carcinoma of Male Breast in Association with the Klinefelter Syndrome, Brit. Med. J. 1:223–225, 1965.

    Article  PubMed  CAS  Google Scholar 

  26. Jacobsen, O.: Heredity in Breast Cancer: A Genetic and Clinical Study of Two Hundred Probands, London, England: H. K. Louis & Co., Ltd., 1946.

    Google Scholar 

  27. Khubchandani, I. T.: World Incidence of Cancer of Large Intestine: Importance of Early Diagnosis, J. Int. Coll. Surg. 43:429–437, 1965.

    Google Scholar 

  28. King, H., Diamond, E., and Lilienfeld, A. M.: Some Epidemiological Aspects of Cancer of the Prostate, J. Chronic Dis. 16:117–153, 1963.

    Article  PubMed  CAS  Google Scholar 

  29. Kirsner, J. B.: The Immunologic Response of the Colon, JAMA 191: 809–814, 1965.

    Article  PubMed  CAS  Google Scholar 

  30. Kluge, T.: Familial Cancer of the Colon, Acta Chir. Scand. 127:392–398, 1964.

    PubMed  CAS  Google Scholar 

  31. Knox, W. G., Miller, R. E Begg, C. F., and Zintel, H. A.: Juvenile Polyps of the Colon, Surgery 48: 201–210, 1960.

    PubMed  CAS  Google Scholar 

  32. Lepore, M. J.: The Importance of Emotional Disturbances in Chronic Ulcerative Colitis, JAMA 191: 819–824, 1965.

    Article  PubMed  CAS  Google Scholar 

  33. Lilienfeld, A. M.: The Epidemiology of Breast Cancer, Cancer Res. 23: 1503–1513, 1963.

    PubMed  CAS  Google Scholar 

  34. Lynch, H. T. and Krush, A. J.: Heredity and Breast Cancer: Implications for Cancer Detection, Medical Times 94: 599–605, 1966.

    PubMed  CAS  Google Scholar 

  35. Lynch, H. T., Shaw, M. W., Magnuson, C. W., Larsen, A. L., and Krush, A. J.: Hereditary Factors in Cancer: Study of Two Large Midwestern Kindreds, Arch. Intern. Med. 117:206–212, 1966.

    Article  PubMed  CAS  Google Scholar 

  36. Lynch, H. T., Larsen, A. L., Magnuson, C. W., and Krush, A. J.: Prostate Carcinoma and Multiple Primary Malignancies: Study of a Family and 109 Consecutive Prostate Cancer Patients, Cancer 19: 1891–1897, 1966.

    Article  PubMed  CAS  Google Scholar 

  37. Lynch, H. T., Krush, A. J., Larsen, A. L., and Magnuson, C. W.: Endometrial Carcinoma: Multiple Primary Malignancies, Constitutional Factors, and Heredity, Amer. J. Med. Sci. 252:381–390, 1966.

    Article  PubMed  CAS  Google Scholar 

  38. Macklin, M. T.: Comparison of the Number of Breast Cancer Deaths Observed in Relatives of Breast-Cancer Patients and the Number Expected on the Basis of Mortality Rates, J. Nat. Cancer Inst. 22:927–951, 1959.

    PubMed  CAS  Google Scholar 

  39. Macklin, M. T.: Relative Status of Parity and Genetic Background in Producing Human Breast Cancer, J. Nat. Cancer Inst. 23: 1179–1189, 1959.

    PubMed  CAS  Google Scholar 

  40. Macklin, M. T.: Inheritance of Cancer of the Stomach and Large Intestine in Man, J. Nat. Cancer Inst. 24:551–571, 1960.

    PubMed  CAS  Google Scholar 

  41. Moertel, C. G., Bargen, J. A., and Dockerty, M. B.: Multiple Carcinomas of the Large Intestine, Gastroenterology 34: 85–98, 1958.

    PubMed  CAS  Google Scholar 

  42. Morganti, G., Gianferrari, L., Cresseri, A., Arrigoni, G., and Lovati, G.: Recherches Clinico-Statistiques et Génétiques sur les Neoplasies de la Prostate, Acta Genet. (Basel) 6: 304–305, 1956.

    PubMed  Google Scholar 

  43. Morris, P. J.: Familial Ulcerative Colitis, Gut 6: 176–178, 1965.

    Article  PubMed  CAS  Google Scholar 

  44. Morson, B. C.: Some Peculiarities in the Histology of Intestinal Polyps, Dis. Colon Rectum 5:337–344, 1962.

    Article  Google Scholar 

  45. Mosbech, J.: ABO Blood Groups in Stomach Cancer, Acta Genet. (Basel) 8: 219–227, 1958.

    Google Scholar 

  46. Mosbech, J.: Heredity in Pernicious Anemia: A Proband Study of the Heredity and the Relationship to Cancer of the Stomach, Copenhagen: Musksgard, 1953.

    Google Scholar 

  47. Murphy, P. P.: Heredity in Uterine Cancer, Cambridge: Harvard University Press, 1952.

    Google Scholar 

  48. Naji, A. F., Salwan, F. A., and Bartunek, R. R.: Adenomatous Polyps of the Colon, Ohio Med. J. 62:(5) 447–452, 1966.

    CAS  Google Scholar 

  49. Oliver, C. P.: Studies on Human Cancer Families, Ann. N. Y. Acad Sci. 71:1198-1212, 1958.

    Article  PubMed  CAS  Google Scholar 

  50. Packson, R. L. and Pockerty, M. B.: The Stein-Leventhal Syndrome: Analysis of 43 Cases with Special Reference Association with Endometrial Carcinoma, Amer. J. Obstet. Gynec. 73:161–173, 1957.

    Google Scholar 

  51. Peltokallio, P. and Peltokallio, V.: Relationship of Familial Factors to Carcinoma of the Colon, Dis. Colon Rectum 9:367–370, 1966.

    Article  PubMed  CAS  Google Scholar 

  52. Penrose, L. S., MacKenzie, H. J., and Karn, M. N.: A Genetical Study of Human Mammary Cancer, Brit. J. Cancer 2, 168–176, 1948.

    Article  PubMed  CAS  Google Scholar 

  53. Polk, H. C., Jr., Spratt, J. S., Jr., and Butcher, H. R., Jr.: Frequency of Multiple Primary Malignant Neoplasms Associated with Colorectal Carcinoma, Amer. J. Surg. 109:71–75, 1965.

    Article  PubMed  Google Scholar 

  54. Richards, R. C. and Woo If, C. M.: Solitary Polyps of Colon and Rectum: Study of Inherited Tendency, Amer. J. Surg. 22:287–294, 1956.

    Google Scholar 

  55. Rider, J. A., Kirsner, J. B., Moeller, H. C., and Palmer, W. L.: Polyps of the Colon and Rectum; Their Incidence and Relationship to Carcinoma, Amer. J. Med. 16:555–564, 1954.

    Article  PubMed  CAS  Google Scholar 

  56. Rotkin, I. P. and King, R. W.: Environmental Variables Related to Cervical Cancer, Amer. J. Obstet. Gynec. 83:720–728, 1962.

    PubMed  CAS  Google Scholar 

  57. Rotkin, I. D.: Further Studies in Cervical Cancer Inheritance, Cancer 19: 1251–1268, 1966.

    Article  PubMed  CAS  Google Scholar 

  58. Stephens, F. E., Garner, E. J., and Woolf, C. M.: Recheck of Kindred 107, Which has Shown a High Frequency of Breast Cancer, Cancer 11: 967–972, 1958.

    Article  PubMed  CAS  Google Scholar 

  59. Stewart, H. L., Dunham, L. J., Casper, J., Dorn, H. F., Thomas, L. B., Edcomb, J. H., and Symeonidis, A.: Epidemiology of Cancers of the Uterine Cervix and Corpus, Breast and Ovary in Israel and New York City, J. Nat. Cancer Inst. 37:1–95, 1966.

    PubMed  CAS  Google Scholar 

  60. Thomson, J. G.: Asbestos as an Urban Air Contaminant, Arch. Path. 81: 458–465, 1966.

    PubMed  CAS  Google Scholar 

  61. Tokuhata, G. K.: Familial Factors in Human Lung Cancer and Smoking, Amer. J. Pub. Health 54:24–32, 1964.

    CAS  Google Scholar 

  62. Turcot, J., Despres, B. D., and St. Pierre, F.: Malignant Tumors of Central Nervous System Associated with Familial Polyposis of Colon, Dis. Colon Rectum 2:465–468, 1959.

    Article  PubMed  CAS  Google Scholar 

  63. Veale, A. M. O., McColl, I., Bussey, H. J. R., and Morson, B. C.: Juvenile Polyposis Coli, J. Med. Genet. 3:1–16, 1966.

    Article  Google Scholar 

  64. Videbaek, Aa. and Mosbech, J.: The Aetiology of Gastric Carcinoma Elucidated by a Study of 302 Pedigrees, Acta Med. Scand. 149:137–159, 1954.

    Article  PubMed  CAS  Google Scholar 

  65. Wassink, W. F.: Cancer et Hérédité, Genetica 17: 103–144, 1935.

    Article  Google Scholar 

  66. Way, S.: The Aetiology of Carcinoma of the Body of the Uterus, J. Obstet. Gynaec. Brit. Comm. 61:46–58, 1954.

    Article  PubMed  CAS  Google Scholar 

  67. Way, S.: Malignant Diseases of the Female Genital Tract, London: Blakiston Co., 1951.

    Google Scholar 

  68. Welch, C. E. and Hedberg, S. E.: Colonic Cancer in Ulcerative Colitis and Idiopathic Colonic Cancer, JAMA 191: 815–818, 1965.

    Article  PubMed  CAS  Google Scholar 

  69. Winterton, W. R.: Discussion on Carcinoma of the Body of the Uterus, Proc. Roy. Soc. Med. 47:897–899, 1954.

    Google Scholar 

  70. Woolf, C. M.: A Further Study on the Familial Aspects of Carcinoma of the Stomach, Amer. J. Hum. Genet. 8:102–109, 1956.

    PubMed  CAS  Google Scholar 

  71. Woolf, C. M.: Investigations on Genetic Aspects of Carcinoma of the Stomach and Breast, Univ. California Pub., Public Health 2: 265–350, 1955.

    CAS  Google Scholar 

  72. Woolf, C. M., Richards, R. C., and Gardner, E. J.: Occasional Discrete Polyps of the Colon and Rectum Showing an Inherited Tendency in a Kindred, Cancer 8: 403–408, 1955.

    Article  PubMed  CAS  Google Scholar 

  73. Woolf, C. M.: An Investigation of the Familial Aspects of Carcinoma of the Prostate, Cancer 13: 739–744, 1960.

    Article  PubMed  CAS  Google Scholar 

  74. Wynder, E. L., Escher, G. C., and Mantel, N.: An Epidemiological Investigation of Cancer of the Endometrium, Cancer 19: 489–520, 1966.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Henry T. Lynch M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1967 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Lynch, H.T. (1967). Heredity and the More Common Malignancies of Man: Carcinoma of the Breast, Stomach, Colon, Lung, Prostate, and Endometrium. In: Hereditary Factors in Carcinoma. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48252-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-48252-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-48254-0

  • Online ISBN: 978-3-642-48252-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation