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Classical Examples of Heredity and Malignancy

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Hereditary Factors in Carcinoma

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Abstract

The role of hereditary factors in many malignant neoplasms is not clear. Undoubtedly non-hereditary factors exist for many of these malignancies. However, several malignant disorders in man show unequivocal evidence clearly indicating a relationship between heredity and carcinoma. These disorders will be discussed in some detail not only for the purpose of a review for clinicians, but also to highlight the critical role which host factors may play in the etiology of these malignant neoplasms. Indeed, the heredity role in these conditions can be predicted with mathematical precision. Malignancy can be predicted in relatives of probands from these kindreds so that cancer detection, and in many cases cancer prevention, can be accomplished.

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References

  1. Anderson, D. E. and Cook, W. A.: Jaw Cysts and the Basal Cell Nevus Syndrome, J. Oral Surg. 24:15–26, 1966.

    PubMed  CAS  Google Scholar 

  2. Anderson, D. E., Taylor, W. B., Falls, H. F., and Davidson, R. T.: The Nevoid Basal Cell Carcinoma Syndrome, 1966, to be published.

    Google Scholar 

  3. Anderson, D. E., McClendon, J. L., and Howell, J. B.: Genetics and Skin Tumors with Special Reference to Basal Cell Nevi in Tumors of the Skin, Chicago: Year Book Medical Publishers, Inc., 1964.

    Google Scholar 

  4. Attie, J. L. and Khafif, R. A.: Melanotic Tumors, Pathology and Clinical Features, Springfield, Illinois: Charles C. Thomas, 1954.

    Google Scholar 

  5. Benedict, E. B.: Carcinoma of the Esophagus Developing in a Benign Structure, New Eng. J. Med. 224:408–412, 1941.

    Article  Google Scholar 

  6. Berlin, N. I., Van Scott, E. J., Clendenning, W. E., Archard, H. O., Witkop, C. J., and Haynes, H. A.: Basal Cell Nevus Syndrome: Combined Clinical Staff Conference at the National Institutes of Health, Ann. Intern. Med. 64:403–421, 1966.

    PubMed  CAS  Google Scholar 

  7. Binkley, G. W. and Johnson, H. H., Jr.: Epithelioma Adenoides Cysticum: Basal Cell Nevi, Agenesis of the Corpus Callosum and Dental Cysts: A Clinical and Autopsy Study, Arch. Derm. 63: 73–82, 1951.

    Article  CAS  Google Scholar 

  8. Bloom, D.: Congenital Telangiectatic Erythema Resembling Lupus Erythematosus in Dwarfs, Amer. J. Pis. Child. 88:754–758, 1954.

    CAS  Google Scholar 

  9. Bloom, D.: The Syndrome of Congenital Telangiectatic Erythema and Stunted Growth, J. Pediat. 68:103–113, 1966.

    Article  PubMed  CAS  Google Scholar 

  10. Bloom, G. F., Warner, S., Gerald, P. S., and Diamond, L. K.: Chromosome Abnormalities in Constitutional Aplastic Anemia, New Eng. J. Med. 274:8–14, 1966.

    Article  PubMed  CAS  Google Scholar 

  11. Butterworth, T. and Strean, L. P.: Clinical Genodermatology, Baltimore: The Williams and Wilkins Co., 1962.

    Google Scholar 

  12. Calabro, J. J.: Heritable Multiple Polyposis Syndromes of the Gastrointestinal Tract, Amer. J. Med. 33:276–281, 1962.

    Article  PubMed  CAS  Google Scholar 

  13. Chung, H.: Keratom Palmare et Plantare Hereditarium. With Special Reference to its Mode of Inheritance in Six and Seven Generations, Respectively in Two Chinese Families, Arch. Belg. Derm. Syph. 36:303–313, 1937.

    Article  Google Scholar 

  14. Clendenning, W. E., Block, J. B., and Radde, I. C.: Basal Cell Nevus Syndrome, Arch. Derm. 90:38–53, 1964.

    Article  PubMed  CAS  Google Scholar 

  15. Clinicopathologic Conference Sponsored by Section on Pathology, State Medical Society of Wisconsin, Wisconsin Med. J. 64:110–115, 1960.

    Google Scholar 

  16. Cook, W. A.: A Family Pedigree - Cancer, Cysts, and Oligodontia, Dent. Radiogr. Photogr. 37:27–46, 1964.

    Google Scholar 

  17. Cushman, P.: Familial Endocrine Tumors: Report of Two Unrelated Kindred Affected with Pheochromocytomas, One Also with Multiple Thyroid Carcinomas, Amer. J. Med. 32:325–360, 1962.

    Google Scholar 

  18. Dahlin, D. C.: Bone Tumors, Springfield, Illinois: Charles C. Thomas, 1957.

    Google Scholar 

  19. de Courcy, J. L. and de Courcy, C. B.: Pheochromocytoma and the General Practitioner, Cincinnati: Barclay Newman, 1952.

    Google Scholar 

  20. Dockerty, M. D.: Pathologic Aspects in the Control of Spread of Colonic Carcinoma, Mayo Clin. Proc. 33:157–163, 1958.

    CAS  Google Scholar 

  21. Dukes, C.: The Hereditary Factor in Polyposis Intestini, Cancer Rev. 5: 241–255, 1930.

    Google Scholar 

  22. El-Hefnawi, H. and Smith, S. M.: Xeroderma Pigmentosum: A Brief Report on its Genetic Linkage with ABO Blood Groups in the United Arab Republic, Brit. J. Derm. 77:35–41, 1965.

    Article  PubMed  CAS  Google Scholar 

  23. Ellison, E. H. and Wilson, S. D.: The Zollinger-Ellison Syndrome - Reappraisal and Evaluation of 260 Registered Cases, Ann. Surg. 160:512–530, 1964.

    Article  PubMed  CAS  Google Scholar 

  24. Fanconi, G.: Familiare Infantile perniziosaartige Anä,mie (perniziöses Blutbild und Konstitution), Jahrb. f. Kinderh. 117:257–280, 1927.

    Google Scholar 

  25. Fejer, R. and Revay, S.: Exostosis Cartilaginea Multiplex Familiaris, Amer. J. Med. 39:296–297, 1965.

    Article  Google Scholar 

  26. Freeman, D. and Lindsay, S.: Medullary Carcinoma of the Thyroid Gland, Arch. Path. 80:575–582, 1965.

    Google Scholar 

  27. Friedell, G. H., Carey, R. J., and Rosen, H.: Familial Thyroid Cancer, Cancer 15: 241–245, 1962.

    Article  PubMed  CAS  Google Scholar 

  28. Gardner, E. J.: Genetic and Clinical Study of Intestinal Polyposis; Predisposing Factor for Carcinoma of Colon and Rectum, Amer. J. Hum. Genet. 3:167–176, 1951.

    PubMed  CAS  Google Scholar 

  29. Gardner, E. J. and Richard, R. C.: Multiple Cutaneous and Subcutaneous Lesions Occurring Simultaneously with Hereditary Polyposis and Osteomatosis, Amer. J. Hum. Genet. 5:139–147, 1953.

    PubMed  CAS  Google Scholar 

  30. Gardner, E. J. and Plenk, H. P.: Hereditary Pattern for Multiple Osteomas in Family Group, Amer. J. Hum. Genet. 4:31–36, 1954.

    Google Scholar 

  31. Gardner, E. J.: Follow-up Study of Family Group Exhibiting Dominant Inheritance for Syndrome Including Intestinal Polyps, Osteomas, Fibromas, and Epidermoid Cysts, Amer. J. Hum. Genet. 14: 376–390, 1960.

    Google Scholar 

  32. German, J.: Bloom’s Syndrome, paper presented to 3rd Congress of Human Genetics, Sept. 5–10, 1966, Chicago, Illinois.

    Google Scholar 

  33. German, J. and Archibald, R.: Chromosomal Breakage in a Rare and Probably Genetically Determined Syndrome of Man, Science 148: 506–507, 1965.

    Article  PubMed  CAS  Google Scholar 

  34. Gorlin, R. J. and Chaudhry, A. P.: Multiple Osteomatosis, Fibromas, Lipomas, and Fibrosarcomas of the Skin and Mesentery, Epidermoid Inclusion Cysts of the Skin, Leiomyomas and Multiple Intestinal Polyposis, New Eng. J. Med. 263:1151–1158, 1960.

    Article  Google Scholar 

  35. Gorlin, R. J., Vickers, R. A., Kelln, E., and Williamson, J. J.: The Multiple Basal-cell Nevi Syndrome. An Analysis of a Syndrome Consisting of Multiple Nevoid Basal-cell Carcinoma, Jaw Cysts, Skeletal Anomalies, Medulloblastoma, and Hyporesponsiveness to Parathormone, Cancer 18: 89–104, 1965.

    Article  PubMed  CAS  Google Scholar 

  36. Gorlin, R. J. and Goltz, R. W.: Multiple Nevoid Basal-cell Epithelioma, Jaw Cysts, and Bifid Rib, A Syndrome, New Eng. J. Med. 262:908–912, 1960.

    Article  Google Scholar 

  37. Hazard, J. B., Hawk, W. A., and Crile, C., Jr.: Medullary (Solid Carcinoma of the Thyroid): A Clinicopathologic Entity, J. Clin. Endocr. 19:152–161, 1959.

    Article  PubMed  CAS  Google Scholar 

  38. Hermans, E. H., Grosfeld, J. C. M., and Spaas, J. A. J.: The Fifth Phacomatoses. Dermatologica (Basel) 130: 447–476, 1965.

    Article  Google Scholar 

  39. Hirschhorn, K. and Swift, M.: Fanconi’s Anemia: Inherited Susceptibility to Chromosome Breakage, paper presented to 3r6d Congress of Human Genetics, Chicago, Illinois, Sept. 5, 1966.

    Google Scholar 

  40. Howel-Evans, A. W., McConnell, R. B., Clarke, C. A., and Sheppard, P. M.: Carcinoma of the Oesophagus with Keratosis Palmaris et Plantaris (Tylosis): A Study of Two Families, Quart. J. Med. 22:413–429, 1958.

    Google Scholar 

  41. Howell, J. B. and Caro, M. R.: The Basal-cell Nevus: Its Relationship to Multiple Cutaneous Cancers and Anomalies of Development, Arch. Derm. 79:67–80, 1959.

    Article  CAS  Google Scholar 

  42. Howell, J. B., Anderson, D. E., and McClendon, J. L.: The Basal Cell Nevus Syndrome, JAMA 190: 274–277, 1964.

    Article  PubMed  CAS  Google Scholar 

  43. Jaffe, H. L.: Tumors and Tumorous Conditions of the Bones and Joints, London: Henry Kimpton, 1958.

    Google Scholar 

  44. Joske, R. A. and Benedict, E. B.: The Role of Benign Esophageal Obstruction in the Development of Carcinoma of the Esophagus, Gastroenterology 36: 749 - 755, 1959.

    PubMed  CAS  Google Scholar 

  45. Lockhart-Mummery, J. P. and Dukes, C. E.: Familial Adenomatosis of Colon and Rectum; Its Relationship to Cancer, Lancet 237: 586–589, 1939.

    Article  Google Scholar 

  46. Lynch, H. T., unpublished data, 1966.

    Google Scholar 

  47. Macklin, M. T.: Xeroderma Pigmentosum, Arch. Derm. Syph. (Chicago) 34: 656–675, 1936.

    Article  Google Scholar 

  48. Maddox, W. D., Winkelmann, R. K., Harrison, E. G., Jr., Devine, K. D., and Gibilisco, J. A.: Multiple Nevoid Basal Cell Epitheliomas, Jaw Cysts, and Skeletal Defects, A Clinical Syndrome, JAMA 188: 106–111, 1964.

    Article  Google Scholar 

  49. McKusick, V. A.: Genetic Factors in Intestinal Polyposis, JAMA 182: 271–277, 1962.

    Article  PubMed  CAS  Google Scholar 

  50. Montgomery, D. A. D. and Welbourn, R. B.: Clinical Endocrinology for Surgeons, Baltimore: Williams and Wi Ikins Co., 1963.

    Google Scholar 

  51. Mosbech, J. and Videbaek, A.: On the Etiology of Esophagea Carcinoma, J. Nat. Cancer Inst. 15:1665–1673, 1955.

    PubMed  CAS  Google Scholar 

  52. Nilsson, L. R.: Chronic Pancytopenia with Multiple Congenital Abnormalities (Fanconi’s Anemia), Acta Paediat. Scand. 49: 518–529, 1960.

    Article  CAS  Google Scholar 

  53. Reiswig, O. K. and Carter, R.: Polyendocrine Adenomatosis with the Zollinger-Ellison Syndrome: Successful Treatment by Total Gastrectomy with a Lawrence Pouch, Amer. J. Surg. 31:695–699, 1965.

    CAS  Google Scholar 

  54. Saltz, N. J.: Surgical Management of Familial Polyposis of the Colon and Rectum, Dis. Colon Rectum 7:417–420, 1964.

    Article  PubMed  CAS  Google Scholar 

  55. Shine, I. and Allison, P. R.: Carcinoma of the Oesophagus with Tylosis (Keratosis Palmaris et Plantaris), Lancet 1: 951–953, 1966.

    Article  PubMed  CAS  Google Scholar 

  56. Sipple, J. H.: The Association of Pheochromocytoma with Carcinoma of the Thyroid Gland, Amer. J. Med. 31:163–166, 1961.

    Article  Google Scholar 

  57. Solomon, L.: Hereditary Multiple Exostosis, J. Bone Joint Surg. (Brit.) 45: 292–304, 1963.

    Google Scholar 

  58. Todaro, G. J. and Swift, M. R.: Susceptibility of Human Diploid Fibroblast Strains to Transformation by SV 40 Virus, Science 153: 1252–1254, 1966.

    Article  PubMed  CAS  Google Scholar 

  59. Vial, K. J.: Hereditary Multiple Exostosis: A Genetic Analysis, Med. J. Aust. 1:213–215, 1966.

    PubMed  CAS  Google Scholar 

  60. Weary, P. E., Linthicu, A., Cawley, E. P., Coleman, C. C., Jr., and Graham, G. F.: Gardner’s Syndrome: A Family Group Study and Review, Arch. Perm. 90:20-30, 1964.

    Article  PubMed  CAS  Google Scholar 

  61. Weiner, R. S. and Cooper, P.: Multiple Polyposis of the Colon, Osteomatosis, and Soft-tissue Tumors. Report of a Familial Syndrome, New Eng. J. Med. 253:795–799, 1955.

    Article  PubMed  CAS  Google Scholar 

  62. Wermer, P.: Genetic Aspects of Adenomatosis of Endocrine Glands, Amer. J. Med. 16:363–371, 1954.

    Article  PubMed  CAS  Google Scholar 

  63. Williams, E. P., Brown, C. L., and Poniach, I.: Pathological and Clinical Findings in a Series of 67 Cases of Medullary Carcinoma of the Thyroid, J. Clin. Path. 19:103–113, 1966.

    Article  PubMed  CAS  Google Scholar 

  64. Williams, E. P.: Histogenesis of Medullary Carcinoma of the Thyroid, J. Clin. Path. 19:114–118, 1966.

    Article  PubMed  CAS  Google Scholar 

  65. Wynder, E. L. and Bross, I. J.: A Study of Etiological Factors in Cancer of the Esophagus, Cancer 14: 389–413, 1961.

    Article  PubMed  CAS  Google Scholar 

  66. Zollinger, R. M. and Ellison, H. E.: Primary Peptic Ulceration of the Jejunum Associated with Islet Cell Tumours of the Pancreas, Ann. Surg. 142:709–728, 1955.

    Article  PubMed  CAS  Google Scholar 

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  1. Henry T. Lynch M.D.
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Lynch, H.T. (1967). Classical Examples of Heredity and Malignancy. In: Hereditary Factors in Carcinoma. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48252-6_2

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  • DOI: https://doi.org/10.1007/978-3-642-48252-6_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-48254-0

  • Online ISBN: 978-3-642-48252-6

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