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Mögliche Mechanismen zur Proliferations- und Differentiationskontrolle

  • H. P. Meinzer
  • H. J. Baur
  • B. Sandblad
  • L. Rodrigues
Conference paper
Part of the Medizinische Informatik und Statistik book series (MEDINFO, volume 71)

Zusammenfassung

Es wird ein Modell der intestinalen Darmkrypte dargestellt, das mit Hilfe eines Computersimulationsexperiments entwickelt wurde. Dieses Modell vereinigt zwei grundlegende Konzepte der Zellproliferations- und Differentiationskontrolle: erstens die Regulation der Proliferation (d.h. die Kontrolle darüber, ob sich eine teilungsfähige Zelle teilt oder nicht) und der Differentiation (d.h. die Funktion der Zelle) durch die zellintern repräsentierte Generationszahl. Zweitens die Regulation der Wiedertierstellung des stabilen Gleichgewichts des Zellverbandes nach einer Störung durch einen inhibitiven Kontrollmechanismus.

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Literatur

  1. [1]
    Cheng, H.; Bjerknes, M.: The Stem Cell Zone of the Mouse Small-Intestinal Epithelium. In Applton, D.R.; Sunter, J.P.; Watson, A.J. (Eds): Cell Proliferation in the Gastrointestinal Tract, 155–165, Pitman Medical, Kent 1980Google Scholar
  2. [2]
    Potten, C.S.; Loeffler, M.: A Comprehensive Model of the Crypts of the Small Intestine of the Mouse Provides Insight to the Mechanisms of Cell Migration and the Proliferation Hierarchy. Journal Theor. Biol. 127(1987) 381–391CrossRefGoogle Scholar
  3. [3]
    Cheng, H., Leblond, C.P. (1974): Origin, Differentiation and renewal of the four main epithel cell types in the mouse small intesine: V. Unitarian theory of the origin of the four epithelial cell types. Am. J. Anat. 141 (1974) 537–562.CrossRefGoogle Scholar
  4. [4]
    Popper, K.R.: Logik der Forschung. Paul Siebeck, Tübingen 1982Google Scholar
  5. [5]
    Cairnie, A.B.; Lamerton, L.F.; Steel, G.G.: Cell Proliferation Studies in the Intestinal Epithelium of the Rat. I. Determination of the Kinetic Parameters. Exp. Cell Res. 39 (1965) 528–538CrossRefGoogle Scholar
  6. [6]
    Meinzer, H.P.; Sandblad, B.: Evidence for Cell Generation Controlled Proliferation in the Small Intestinal Crypt. Cell Tissue Kinet. 19 (1986) 581–590Google Scholar
  7. [7]
    Cairnie, A.B.; Lamerton, L.F.; Steel, G.G.: Cell Proliferation Studies in the Intestinal Epithelium of the Rat. II. Theoretical Aspects. Exp. Cell Res. 39 (1965) 539–553CrossRefGoogle Scholar
  8. [8]
    Potten, C.S., Chwalinsky, S., Swindell, R., Palmer, M. (1982): The spatial organisation of the hierarchical proliferative cells of the crypts of the small intestine into clusters of ’synchronized’ cells. Cell and Tissue Kinetics 15 (1982) 351–370.Google Scholar
  9. [9]
    Al-Dewachi, H.S.; Wright, N.A.; Appleton, D.R.; Watson, A.J.: The Cell Cycle Time in the Rat Jejunal Mucosa. Cell Tissue Kinet. 7 (1974) 587–594Google Scholar
  10. [10]
    Potten, C.S., Hendry, J.H., Moore, J.V. (1987): Estimates of the number of clonogenic cells in crypts of murine small intestine. Virchows Archiv B 53 (1987) 227–234.CrossRefGoogle Scholar
  11. [11]
    Ponder, B.A.J.; Schmidt, G.H.; Wilkinson, M.M.: Derivation of Mouse Intestinal Crypts from Single Progenitor Cells. Nature 313 (1985) 689–691CrossRefGoogle Scholar
  12. [12]
    Totafurno, J.; Bjerknes, M.; Cheng, H.: The Crypt Cycle. Crypt and Villus Production in the Adult Intestinal Epithelium. Biophysical Journal 52 (1987) 279–294CrossRefGoogle Scholar
  13. [13]
    Wright, N.A.; Al-Nafussi, A.: The Kinetics of Villus Cell Populations in the Mouse Small Intestine. II: Studies on Growth Control after Death of Proliferative Cells Induced by Cytosine Arabinoside, with special reference to Negative Feedback Mechanisms. Cell Tissue Kinet. 15 (1982) 611–621Google Scholar
  14. [14]
    Soto, A.M.; Sonnenschein, C.: Cell Proliferation of Estrogen-sensitive Cells: The Case of Negative Control. Endocrine Review 8 (1987) 44–52CrossRefGoogle Scholar
  15. [15]
    Cairns, J.: Mutation, selection and the natural history of cancer. Nature 225 (1975) 197–200.CrossRefGoogle Scholar
  16. [16]
    Potten, C.S., Hume, W.J., Reid, P., Cairns, J.: The segregation of DNA in epithelial stem cells. Cell 15 (1978) 899–906.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. P. Meinzer
    • 1
  • H. J. Baur
    • 1
  • B. Sandblad
    • 2
  • L. Rodrigues
    • 1
  1. 1.Abteilung Biologische und Medizinische InformatikDeutsches Krebsforschungszentrum HeidelbergDeutschland
  2. 2.Uppsala DatacentralUppsala UniversitySchweden

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