Skip to main content

Tag-Nacht-Rhythmen von Neurohormonen bei epileptischen Kindern vor und unter Carbamazepinmonotherapie

  • Conference paper
  • 29 Accesses

Zusammenfassung

Carbamazepin (CBZ) ist ein potentes Antikonvulsivum, wird aber auch wegen seiner psychotropen Wirkung zur Behandlung der akuten Depression und bei der manisch-depressiven Erkrankung [3, 35], sowie als Analgetikum bei der Trigeminusneuralgie eingesetzt [5, 23]. Dabei ist in den letzten Jahren vermehrt über einen Einfluß von CBZ auf das Hormonsystem berichtet worden. Unter der Therapie mit CBZ wurden erniedrigte Plasmanatriumwerte gemessen [19, 20] und in einigen Fällen kam es zu einer Wasserintoxikation [1, 15, 34, 48, 49].

This is a preview of subscription content, log in via an institution.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Ashton MG, Ball SG, Thomas TH, Lee MR (1977) Water intoxication with carbamazepin treatment. Br Med J 1: 1134–1135

    Article  PubMed  CAS  Google Scholar 

  2. Attanasio A, Borrelli P, Gupta D (1985) Circadian rhythms in serum melatonin from infancy to adolescence. J Clin Endocrinol Metab 61: 388–390

    Article  PubMed  CAS  Google Scholar 

  3. Ballenger JC, Post RM (1980) Carabamazepine (Tegretol) in manic-depressive illness: a new treatment. Am J Psychiatry 137: 782–790

    PubMed  CAS  Google Scholar 

  4. Bentsen KD, Gram L, Veje A (1983) Serum thyroid hormones and blood folic acid during monotherapy within carbamazepine or valproate. Acta Neurol Scand 67: 235–41

    Article  PubMed  CAS  Google Scholar 

  5. Blom S (1962) Trigeminal neuralgia: Its treatment with a new anticonvulsant drug G 32883. Lancet I: 839–40

    Google Scholar 

  6. Bonucelli U, Murialdo G, Martino E, Lecchini S, Bonura ML, Bambini G, Murri L (1985) Effects of carbamazepine on prolactin secretion in normal subjects and in epileptic subjects. Clin Neuropharmacol 8: 165–174

    Article  Google Scholar 

  7. Clarenbach P, Wachner R, Lucius G, Kanno O, Cramer H (1981) EEG-Befunde, neuroendokrinologische and psychometrische Untersuchungen zur Carbamazepin-Wirkung. Arch Psychiatr Nervenkr 230: 197–207

    Article  PubMed  CAS  Google Scholar 

  8. Connell JMC, Rapeport WG, Gordon S, Brodie MT (1984) Changes in circulating thyroid hormones during short-term hepatic enzyme induction with carbamazepine. Eur J Clin Pharmacol 26: 453–456

    Article  PubMed  CAS  Google Scholar 

  9. Dana-Haeri J, Oxley J, Richens A (1984) Pituitary responsiveness to gonadotrophin-releasing and thyrotrophin-releasing hormones in epileptic patients recieving carbamazepine or phenytoin. Clin Endocrinol 20: 163–168

    Article  CAS  Google Scholar 

  10. Ericsson UB, Bjerre I, Forsgren M, Ivarsson S (1985) Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine and valproic acid. Epilepsia 26: 594–596

    Article  PubMed  CAS  Google Scholar 

  11. Fichsel H (1980) Antikonvulsiva and Neuroendokrinum. In: Mertens HG, Przuntek H (Hrsg) Pathologische Erregbarkeit des Nervensystems and ihre Behandlung. Springer, Berlin Heidelberg New York, S. 703–705

    Google Scholar 

  12. Fichsel H (1981) Hormonal changes in children recieving antiepileptic drugs. In: Dam M, Gram L, Penry JK (eds) Advances in epileptology. XIIth Epilepsy International Symposium. Raven, New York, pp 449–459

    Google Scholar 

  13. Fichsel H, Knöpfle G (1977) Carbamazepin-bedingte Veränderungen im Schilddrüsenhormonsystem bei der antikonvulsiven Dauertherapie epileptischer Kinder and Jugendlicher. Klin Pädiatr 189: 455–462

    PubMed  CAS  Google Scholar 

  14. Fichsel H, Knöpfle G (1978) Effects of anticonvulsant drugs on thyroid hormones in epileptic children. Epilepsia 19: 323–336

    Article  PubMed  CAS  Google Scholar 

  15. Flegel KM (1977) Inappropriate antidiuresis during carabamazepine treatment. Ann Intern Med 87: 722–724

    PubMed  CAS  Google Scholar 

  16. Frahm H, Smeijkal E, Kratzenstein R (1969) Antidiuretic effects of an anticonvulsant drug (5-carbamyl-5H-dibenzo(B,F)azepintegretol) associated with diabetes insipidus and of patients with polyuria and polydipsia following hypophysectomy. Acta Endocrinol [Suppl] 138: 240

    Google Scholar 

  17. Franceschi M, Perego L, Cavagnini F, Cattaneo AG, Invitti C, Caviezel F, Strambi LF, Smirne S (1984) Effects of long-term antiepileptic therapy on the hypothalamic-pituitary axis in man. Epilepsia 25: 46–52

    Article  PubMed  CAS  Google Scholar 

  18. Gold PW, Robertson GL, Ballenger JC, Kaye W, Chen J, Rubinow DR, Goodwin FK, Post RM (1983) Carbamazepine diminishes the sensitivity of the plasma arginine vasopressin response to osmotic stimulation. J Clin Endocrinol Metab 57: 952–957

    Article  PubMed  CAS  Google Scholar 

  19. Helin T, Nillson KO, Bjeue I, Vegfors P (1977) Serum sodium and osmolality during carbamazepine treatment in children. Br Med J 2: 558

    Article  PubMed  CAS  Google Scholar 

  20. Henry DA, Lawson DH, Reary P, Renfrew S (1977) Hyponatremia during carbamazepine treatment. Br Med J 1: 83–84

    Article  PubMed  CAS  Google Scholar 

  21. Joffe RT, Gold PW, Uhde TW, Post RM (1984) Effects of carbamazepine on the thyrotropin response to thyrotropin — releasing hormone. Psychiatry Res 12: 161–166

    Article  PubMed  CAS  Google Scholar 

  22. Joffe RT, Post RM, Ballenger JC, Rebar R, Gold PW (1986) Neuroendocrine effects of carbamazepine in patients with affective illness. Epilepsia 27: 156–160

    Article  PubMed  CAS  Google Scholar 

  23. Killian JM, Fromm GH (1968) Carbamazepine in the treatment of neuralgia: Use and side effects. Arch Neurol 19: 129–136

    Google Scholar 

  24. Kimura T, Matsui K, Sato T, Yosinga K (1974) Mechanism of carbamazepine ( Tegretol) induced antidiuresis: Evidence for release of antidiuretic hormone and impaired excretion of a water load. J Clin Endocrinol Metab 38: 356–362

    Google Scholar 

  25. Lewy AJ, Wehr TA, Goodwin FK, Newsome DA, Markey SP (1980) Light suppresses melatonin secretion in humans. Science 210: 1267–1269

    Article  PubMed  CAS  Google Scholar 

  26. Liappis N (1985) Fluoreszenzpolarisations-Immunoassay, eine neue Meßtechnik in der klinisch-chemischen Routinediagnostik von Medikamentenspiegeln. Klin Pädiatr 197: 302–304

    Article  PubMed  CAS  Google Scholar 

  27. Liewendahl K, Majuri H, Helenius T (1978) Thyroid function tests in patients on long-term treatment with various anticonvulsant drugs. Clin Endocrinol 8: 185–191

    Article  CAS  Google Scholar 

  28. London DR (1980) Hormonal effects of anticonvulsant drugs. In: Canger R, Angeleri F, Penry JK (eds) Advances in epileptology: XIth Epilepsy International Symposium. Raven, New York, pp 431–433

    Google Scholar 

  29. Luoma PV, Myllylä VV, Kokkanen E (1980) Elevated serum growth hormone levels in patients treated with anticonvulsants. In: Canger R, Angeleri F, Penry JK (eds) Advances in epileptology: XIth Epilepsy International Symposium. Raven, New York, pp 431–433

    Google Scholar 

  30. Meinders AE, Cejka V, Robertson GL (1974) The antidiuretic effect of carbamazepine in man. Clin Sci Mo Med 47: 289–291

    CAS  Google Scholar 

  31. Moore DC, Paunier L, Sizonenko PC (1979) Effect of adrenergic stimulation and blockade on melatonin secretion in the human. Prog Brain Res 52: 517–521

    Article  PubMed  CAS  Google Scholar 

  32. Morselli PL, Calderini G, Consolazione A, Riva E, Altamura C (1978) Effect of carbamazepine on brain meditors in control and cobalt treated rats. In: Meinardi H, Rowan M (eds) Advances in epileptology: IXth Epilepsy International Symposium. Swets & Zeitlinger, Amsterdam, S 176182

    Google Scholar 

  33. Ozaki Y, Lynch HJ, Wurtman RJ (1976) Melatonin in rat pineal, plasma and urine: 24-hour rhythmicity and effect of chlorpromazine. Endocrinology 98: 1418–1424

    Article  PubMed  CAS  Google Scholar 

  34. Perruca E (1980) Water intoxikation produced by carbamazepine and its reversal by phenytoin. Br J Clin Pharmacol 9: 302

    Google Scholar 

  35. Post RM, Uhde TW, Ballenger JC, Squillace KM (1983 a) Prophylactic efficacy of carbamazepine in manic-depressive illness. Am J Psychiatry 140: 1602–1604

    Google Scholar 

  36. Post RM, Uhde TW, Rubinow DR, Ballenger JC, Gold PW (1983 b) Biochemical effects of carbamazepine: relationship to its mechanisms of action in affective illness. Prog Neuropsychopharmacol Biol Psychiatry 7: 263–271

    Google Scholar 

  37. Post RM, Rubinow DR, Uhde TW, Ballenger JC, Linnoila M (1986) Dopaminergic effects of carbamazepine: relationship to clinical response in affective illness. Arch Gen Psychiatry 43: 392396

    Google Scholar 

  38. Pratt JA, Jenner J, Johnson AL, Shorvon SD, Reynolds EH (1984) Anticonvulsant drugs alter plasma tryptophan concentrations in epileptic patients: implication for antiepileptic action and mental function. J Neurol Neurosurg Psychiatry 47: 1131–1133

    Article  PubMed  CAS  Google Scholar 

  39. Privitere MR, Gredan JF, Gardner RW, Ritchie JC, Carroll BJ (1982) Interference by carbamazepine with the dexamenthasone suppression test. Biol Psychiatry 17: 611–620

    Google Scholar 

  40. Purdy RE, Julien RM, Fairburst AS (1977) Effect of carbamazepine in adrenergic nerves of rabbit aorta and in whole brain synaptosomes. Epilepsia 18: 251–257

    Article  PubMed  CAS  Google Scholar 

  41. Rollag MD, Niswander GE (1976) Radioimmunoassay of serum melatonin concentrations in sheep exposed to different lighting regimens. Endocrinology 98: 482–486

    Article  PubMed  CAS  Google Scholar 

  42. Rootwelt K, Ganes T, Johannessen SI (1978) Effect of carbamazepine, phenytoin and phenobarbitone on serum levels of thyroid hormones and thyrotropin in humans. Scand J Clin Lab Invest 38: 731–736

    Article  PubMed  CAS  Google Scholar 

  43. Rousso I, Pharmakiotis E, Gatzola M, Karatza E, Tourkantonis A, Sklavounou-Tsouroutsoglou S (1984) Effects of phenobarbital, diphenylhydantoin and carbamazepine on serum levels of thyroid function in epileptic children. Acta Endocrinol [Suppl] 265: 48–49

    CAS  Google Scholar 

  44. Roy-Vyme PP, Joffe RT, Uhde TW, Post RM (1984) Carbamazepine and thyroid function in affectively ill patients. Arch Gen Psychiatry 41: 1150–1153

    Article  Google Scholar 

  45. Rubinow DR, Post RM, Gold PW, Uhde TW (1984) Neuroendocrine and peptide effects of carbamazepine: clinical and mechanistic implications. Psychopharmacol Bull 20: 590–594

    PubMed  CAS  Google Scholar 

  46. Rubinow DR, Post RM, Gold PW, Ballenger JC, Reichlin S (1985) Effects of carbamazepine on cerebrospinal fluid somatostatin. Psychopharmacology (Berlin) 85: 210–213

    Article  CAS  Google Scholar 

  47. Scanlon MF, Pourmand M, Mc Gregor AM, Rodriquez-Amoa MD, Hall K, Gomez-Pan A, Hall R (1973) Some current aspects of clinical and experimental neuroendocrinology with particular reference to growth hormone, thyrotropin and prolactin. J Endocrinol Invest 2: 307–330

    Google Scholar 

  48. Smith NJ, Espie MLE, Baylis PH (1977) Raised plasma arginine vasopressine concentration in carbamazepine-induced water intoxikation. Br Med J 2: 804

    Article  PubMed  CAS  Google Scholar 

  49. Stephens WP, Espie MLE, Tatterstall RB, Quinn NP, Gladwell SRF, Galbraith AW, Raynolds EH (1977) Water intoxication due to carbamazepine. Br Med J 1: 754–755

    Article  PubMed  CAS  Google Scholar 

  50. Stephens WP, Coe JY, Baylis PH (1978) Plasma arginine vasopressin concentration and the antidiuretic action of carbamazepine. Br Med J 1: 1445–1447

    Article  PubMed  CAS  Google Scholar 

  51. Strandjord RE, Aanderud S, Myking OL, Johannessen SI (1981) Influence of carbamazepine on serum thyroxine and triiodthyronine in patients with epilepsy. Acta Neurol Scand 63: 111–121

    Article  PubMed  CAS  Google Scholar 

  52. Tada H. Wallace SJ, Hughes IA (1986) Height in epilepsy. Arch Dis Child 61: 1224–1226

    Article  PubMed  CAS  Google Scholar 

  53. Tartara A, Manni R, Deldovici ML, Bonura ML, Murialdo N (1984) Pituitary function, testosteron and SHBG levels in treated epileptic male subjects. In: Porter RJ, Mattson RM, Ward AA, Dam M (eds) Advances in epileptology: XVth Epilepsy International Symposium. Raven, New York, pp 209–214

    Google Scholar 

  54. Tietze HU, Finkenwirth H (1979) Beeinflussung des Diabetes insipidus durch Tegretal. Monatsschr Kinderheilk 118: 237–238

    Google Scholar 

  55. Uhlich E, Werder K von (1973) Einfluß von Carbamazepin auf die Sekretion von Wachstumshormon ( GH ). Kiln Wochenschr 50: 981–983

    Google Scholar 

  56. Vaughan GM, Pelham RW, Pang SF, Loughlin LL, Wilson KM, Sandock KL, Vaughan MK, Koslow SH (1976) Nocturnal elevation of plasma melatonin and urinary 5-hydroxyindole-aceticacid in young men: attempts at modification by brief changes in environmental lighting and sleep by autonomic drugs. J Clin Endocrinol Metab 42: 752–764

    Article  PubMed  CAS  Google Scholar 

  57. Waldhauser F, Lynch HJ, Wurtman RJ (1984) Melatonin in human body fluids: Clinical significance. In: Reiter RJ (eds) The pineal gland. Raven, New York, pp 345–370

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Roßkamp, R., Attanasio, A., Fichsel, H., Fuchs, V., Müller, F. (1987). Tag-Nacht-Rhythmen von Neurohormonen bei epileptischen Kindern vor und unter Carbamazepinmonotherapie. In: Fichsel, H. (eds) Aktuelle Neuropädiatrie 1986. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-47569-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-47569-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-47571-9

  • Online ISBN: 978-3-642-47569-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics