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Die Biochemie der progressiven Muskeldystrophie

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Zusammenfassung

Im Jahre 1962 wurde von den hervorragenden französischen Forschern Jean-Claude Dreyfus und Georges Schapira erstmalig eine Zusammenstellung und kritische Bewertung aller bis dahin bekannten biochemischen Untersuchungs-ergebnisse bei den erblichen Myopathien vorgenommen [253]. Die unter dem Titel „Biochemistry of Hereditary Myopathies“ veröffentlichte Monographie hat großes Interesse hervorgerufen und die Forschung auf diesem Gebiet wesentlich stimuliert. Seitdem hat die Zahl der Einzelbefunde außerordentlich zugenommen, wobei besonders die verschiedenen Formen der progressiven Muskeldystrophien mit einer Fülle neuer Untersuchungsergebnisse hervorragen. Zwar konnte die molekulare Genetik dieser Leiden immer noch nicht geklärt werden, doch hat die moderne biochemische Forschung einige Anhaltspunkte geliefert und die Richtung für zukünftige, möglicherweise Erfolg versprechende Untersuchungen gewiesen.

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