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Pathogenese, Prävention und Therapie der Arteriosklerose

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Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 87))

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Zusammenfassung

Die Folgen einer Arteriosklerose führen bei Tieren in freier Wildbahn kaum einmal zum Tode, während sie beim Menschen heute in vielen Ländern die häufigste Todesursache darstellen. Wir wissen nicht, wie das Gefäßsystem unserer Neandertaler Vorfahren ausgesehen hat, aber wir wissen, daß die Arteriosklerose keine erst in jüngster Zeit entstandene Zivilisationskrankheit ist. So sind z. B. deutliche arteriosklerotische Gefäßveränderungen bei ägyptischen Mumien nachgewiesen worden. Es ist möglich, daß der Mensch nicht für die Nahrung geschaffen ist, die er heutzutage zu sich nimmt, und auch nicht für die soziologischen Strukturen, unter denen er lebt (Haust).

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Literatur

  1. Anitschkow N (1928) Über die Rückbildungsvorgänge bei der experimentellen Atherosklerose. Verh Dtsch Ges Pathol 23: 473–478

    Google Scholar 

  2. Asano G, Ohkubo K, Hoshino M, Yamada N, Aihara K (1979) Early changes in the arterial endothelium under various pathological conditions. Acta Pathol Jpn 29: 21–34

    PubMed  CAS  Google Scholar 

  3. Aschoff L (1924) Lectures in pathology. Hoeber, New York, NY

    Google Scholar 

  4. De Bakey M (1979) Research related to surgical treatment of aortic and peripheral vascular disease. Circulation 60: 1619–1635

    Article  Google Scholar 

  5. Benditt E (1978) The monoclonal theory of atherogenesis. In: Paoletti R, Gotto AM Jr (eds) Atherosclerosis reviews, vol 3. Raven Press, New York, pp 77–85

    Google Scholar 

  6. Benditt EP, Gown AM (1980) Atheroma: the artery wall and the environment. Int Rev Exp Pathol 21: 55–118

    PubMed  CAS  Google Scholar 

  7. Blankenhorn D (1975) Evidence for regression/progression of atherosclerosis in man. Int. Workshop on Atherosclerosis. London, Ontario

    Google Scholar 

  8. Böger A, Hort W (1977) The importance of smooth muscle cells in the development of foam cells in the gastric mucosa. An electron microscopic study. Virchows Arch [Pathol Anat] 372: 287–297

    Google Scholar 

  9. Buja LM, Kovanen PT, Bilheimer DW (1979) Cellular pathology of homozygous familial hypercholesterolemia. Am J Pathol 97: 327–358 — Burns ER, Friedman RJ, Tiell ML, Spät TH, Stemerman MB (1976) Platelet activity in pathogenesis of atherosclerosis. N Engl J Med 295: 1199

    Google Scholar 

  10. Chapman I (1965) Morphogenesis of occluding coronary artery thrombosis. Arch Pathol Lab Med 80: 256

    CAS  Google Scholar 

  11. Constantinides P (1966) Plaques fissures in human coronary thrombosis. Atherosclerosis 6: 1

    Article  Google Scholar 

  12. Daoud AS, Fritz KE, Augustyn JM, Jarmolych J (1978) Regression of advanced atherosclerosis inswine. In: Hauss WH, Wissler RW, Lehmann R (eds) Int. Sympos.: State of prevention and therapy in human arteriosclerosis and in animal models, Bd 63. Abh. Rhein.- Westf. Akad. Wiss., pp 173–181

    Google Scholar 

  13. Doerr W (1964) Gangarten der Arteriosklerose. Sitzungsber. Heidelberger Akad. Wiss., math., nat. Kl. 1962/64, Abh. 4. Springer, Berlin

    Book  Google Scholar 

  14. Duguid JB (1946) Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. J Pathol 58: 207

    Article  CAS  Google Scholar 

  15. Eitel W, Schmid G, Schlote W, Betz E (1980) Early arteriosclerotic changes of the carotid artery wall induced by electrostimulation. Path Res Pract 170: 211–229

    Article  PubMed  CAS  Google Scholar 

  16. Epstein FH, Gutzwiller F, Howald H, Junod B, Schweizer W (1979) Prävention der Atherosklerose: Grundlagen heute. Schweiz Med Wochenschr 109: 1171–1180

    Google Scholar 

  17. Feinleib M, Kannel WB, Tedeschi CG, Landau TK, Garrison RJ (1979) The relation of antemortem characteristics to cardiovascular findings at necropsy.

    Google Scholar 

  18. The Framingham Study. Atherosclerosis 34: 145–157

    Google Scholar 

  19. Friedman M, Van den Bovenkamp GJ (1966) The pathogenesis of a coronary thrombus. Am J Pathol 48: 19

    PubMed  CAS  Google Scholar 

  20. Gabbiani G, Elemer G, Guelpa Ch, Vallotton MB, Badonnel M-C, Hüttner I (1979) Morphologic and functional changes of the aortic intima during experimental hypertension. Am J Pathol 96: 399–422

    PubMed  CAS  Google Scholar 

  21. Gröschel-Stewart U (1980) Immunochemistry of cytoplasmic contractile proteins. Int Rev Cytol 65: 194–254

    Google Scholar 

  22. Haust MO (1978) Atherosclerosis in childhood. Perspect Pediatr Pathol 4: 155–216

    PubMed  CAS  Google Scholar 

  23. Hort W, Hemieda B (1976) Morphologische Aspekte der chronischen arteriellen Verschlußkrankheit an den unteren Extremitäten. Therapiewoche 26: 5018–5021

    Google Scholar 

  24. Hort W, Hort I (im Druck) Von der Amöbe zum schlagenden Herzen: Evolution und Feinstruktur des intrazellulären Bewegungsapparates. Klirr Wochenschr

    Google Scholar 

  25. Hort W, Nauth HF (1975) Die Risikofaktoren der koronaren Herzkrankheit aus pathologisch-anatomischer Sicht. In: Holtmeier HJ, Siegenthaler W (Hrsg) 12. Symposion d. Dtsch. Ges. f. Fortschr. d. Inn. Med. 1974. Thieme, Stuttgart, S 5–16

    Google Scholar 

  26. Hüttner I, Badonnel M-C, Elemer G, Gabbiani G (1979) Aortic intima of the rat in various phases of hypertension. Exp Mol Pathol 31: 191–200

    Article  PubMed  Google Scholar 

  27. Hurukowa Z (im Druck) Kollagenabbau durch Phagozytose in glatten Muskelzellen bei der Rückbildung experimenteller Atherosklerose. Der Pathologe

    Google Scholar 

  28. Kadish JL (1979) Fibrin and atherogenesis — a hypothesis. Atherosclerosis 33: 409–413

    Article  PubMed  CAS  Google Scholar 

  29. Kief H, Kobayashi T (1978) Stand der experimentellen Atherogeneseforschung. Med Welt 29: 1135–1136

    PubMed  CAS  Google Scholar 

  30. Kramsch DM (1978) The role of connective tissue in atherosclerosis. Adv Exp Med Biol 109: 155–194

    Article  PubMed  CAS  Google Scholar 

  31. Lenz W (1981) Die hypertonische Koronararterienerkrankung im Tierexperiment.

    Google Scholar 

  32. Linzbach AJ (1957/58) Die Bedeutung der Gefäßwandfaktoren für die Entstehung der Arteriosklerose. Verh Dtsch Ges Pathol 41:24–41

    Google Scholar 

  33. McGill HC Jr. Atherosclerosis: Problems in pathogenesis. In: Paoletti R, Gotto AM Jr (eds) Atherosclerosis reviews, vol 2. Raven Press New York, pp 27–65

    Google Scholar 

  34. Malinow MR (1980) Atherosclerosis. Regression in nonhuman primates. Circ Res 46: 311–320

    Article  PubMed  CAS  Google Scholar 

  35. Meessen H, Kojimahara M, Franken T, Rhedin P, Huth F (1975) Alterations of the rabbit aorta following feeding of cholesterol diet in combination with sheating of aortic segments by polyethylene tubos. Beitr Pathol 154: 218

    Article  PubMed  CAS  Google Scholar 

  36. Moore S (1979) Endothelial injury and atherosclerosis. Exp Mol Pathol 31: 182–190

    Article  PubMed  CAS  Google Scholar 

  37. Nauth HF, Hort W, Hubinger R (1979) Untersuchungen über die Lokalisation sklerotischer Veränderungen in den Koronararterien und ihren großen epikardialen Ästen. Z Kardiol 68: 832–838

    PubMed  CAS  Google Scholar 

  38. Nerem RM, Cornhill FR (1980) Hemodynamics and atherogenesis. Atherosclerosis 36: 151–157

    Article  PubMed  CAS  Google Scholar 

  39. Pearson TA, Dillman JM, Solez K, Heptinstall RH (1980) Evidence for two populations of fatty streaks with different roles in the atherogenic process. Lancet 2: 496–498

    Article  PubMed  CAS  Google Scholar 

  40. Pietilä K, Nikkari T (1980) Enhanced growth of smooth muscle cells from atherosclerotic rabbit aortas in culture. Atherosclerosis 36: 241–248

    Article  PubMed  Google Scholar 

  41. Robertson AL Jr (1978) The spectrum of arterial disease. Atherosclerosis Reviews 3: 57–68

    Google Scholar 

  42. Ross R, Glomset J, Harker L (1978) The response to injury and atherogenesis: The role of endothelium and smooth muscle. In: Paoletti R, Gotto AM Jr (eds) Atherosclerosis reviews, vol 3. Raven Press, New York

    Google Scholar 

  43. Schaffner Th, Zimmermann A, Keller HU, Locher GW, Cottier H (1978) Der Einfluß immunologischer Mechanismen auf die Atherogenese. Med Welt 29: 1118–1122

    PubMed  CAS  Google Scholar 

  44. Schaffner Th, Taylor K, Bartucci EJ, Fischer-Dzoga K, Beeson JH, Glagov S, Wissler RW (1980) Am J Pathol 100: 57–80

    PubMed  CAS  Google Scholar 

  45. Schettler G (1980) Pathophysiologie, Klinik und prognostische Bedeutung der Hyperlipoproteinämien. Dtsch Ärzteblatt 11: 661–668

    Google Scholar 

  46. Schilling (1925) Experimentelle Erzeugung von Intimahyperplasien. Verh Dtsch Ges Pathol 20: 154–158

    Google Scholar 

  47. Schwartz CJ, Gerrity RG, Lewis LJ (1978) Arterial endothelial structure and function with particular reference to permeability. Atherosclerosis Reviews 3: 109–124

    CAS  Google Scholar 

  48. Sinapius D (1965) Über Wandveränderungen bei Koronarthrombose. Klirr Wochenschr 43: 875–880

    Article  CAS  Google Scholar 

  49. Sinapius D (1978) Häufigkeit und Morphologie atherosklerotischer Frühveränderungen in verschiedenen Gefäßabschnitten. Med Welt 29: 1128–1131

    PubMed  CAS  Google Scholar 

  50. Sinzinger H, Feigl W, Oppolzer R, Leithner Ch (1978) Aktivierte modifizierte glatte Muskelzelle: Morphologie, Metabolismus, Verteilung und Übergangsformen. Z Gesamte Inn Med 33: 589–592

    Google Scholar 

  51. Stein PD, Sabbah HN, Anbe DT, Walburn FJ (1979) Blood velocity in the abdominal aorta and common iliac artery of man. Biorheology 16: 249–255

    PubMed  CAS  Google Scholar 

  52. Strong JS, Gutzman MA (1980) Decrease in coronary atherosclerosis in New Orleans. Lab Invest 43: 297–301

    PubMed  CAS  Google Scholar 

  53. Thomas WA, Janakidevi K, Reiner JM, Florentin RA (1978) Some aspects of populations dynamics of arterial smooth muscle cells in atherogenesis. In: Paoletti R, Gotto AM Jr (eds) Atherosclerosis reviews, vol 3. Raven Press, New York, pp 87–95

    Google Scholar 

  54. Velican C, Velican D (1980) Incidence, topography and light-microscopic feature of coronary atherosclerotic plaques in adults 26–35 years old. Atherosclerosis 35: 111–122

    Article  PubMed  CAS  Google Scholar 

  55. Wissler RW (1978) Progression and regression of atherosclerotic lesions. In: Chandler AB et al. (eds) The thrombotic process in atherogenesis. Plenum Press, New York London, pp 77–110

    Chapter  Google Scholar 

  56. Bollinger A, Schneider E, Pouliadis G, Brunner U (1980) Thrombozytenfunktionshemmer und Antikoagulantien nach gefäßrekonstruktiven Eingriffen im femoro-poplitealen Bereich: Resultate einer prospektiven Studie, V. Colfarit-Symposium, Mainz

    Google Scholar 

  57. Burkhalter A, Widmer LK, Glaus L (1974) Chronischer Gliedmassenarterienverschluß und Langzeitantikoagulation. Vasa 3: 185–189

    PubMed  CAS  Google Scholar 

  58. Canadian Cooperative Stroke Study Group (1980) Randomized trial of therapy with platelet antiaggregants for threatened stroke. CMA J 122: 293–296

    Google Scholar 

  59. Dyken ML (1980) Antiplatelet agents in transient ischemic attacks and the relationship of risk factors, V. Colfarit-Symposium, Mainz

    Google Scholar 

  60. Ehresmann U, Alemany J, Loew D (1977) Prophylaxe von Rezidivverschlüssen nach Revaskularisationseingriffen mit Acetylsalicylsäure. Med. Welt 28: 1157–1162

    Google Scholar 

  61. Fields WS, Lemak NA, Frankowski RF, Hardy RJ (1977) Controlled trial of aspirin in cerebral ischemia. Stroke 8: 301–315

    Article  PubMed  CAS  Google Scholar 

  62. Hess H, Müller-Fassbender H, Ingrisch H, Mietasck A (1978) Verhütung von Wiederverschlüssen nach Rekanalisation obliterierter Arterien mit der Kathethermethode. Dtsch Med Wochenschr 103: 1994: 1997

    Google Scholar 

  63. Olsson JE, Brechter C, Bäcklund H, Krook H, Müller R, Nitelius E, Olsson O, Tornberg A (1980) Anticoagulant vs antiplatelet therapy as prophylactic against cerebral infarction in transient ischemic attacks. Stroke 11: 4–9

    Article  PubMed  CAS  Google Scholar 

  64. Reuther R, Dorndorf W, Loew D (1980) Behandlung transitorisch-ischämischer Attacken mit Acetylsalicylsäure, Münch Med Wochenschr 122: 795–798

    CAS  Google Scholar 

  65. Schoop W (1979) Progression der arteriellen Verschlußkrankheit unter Aggregationshemmern. In: Ehringer H, Betz E, Bollinger A, Deutsch E (Hrsg) Gefäßwand, Rezidivprophylaxe, Raynaud-Syndrom. Witzstrock, Baden-Baden, S 262–267

    Google Scholar 

  66. Zeitler E, Reichold J, Schoop W, Loew D (1973) Einfluß von Acetylsalicylsäure auf das Frühergebnis nach perkutaner Rekanalisation arterieller Obliterationen nach Dotter. Dtsch Med Wochenschr 98: 1285–1288

    Article  PubMed  CAS  Google Scholar 

  67. Andersen MP, Frederiksen J, Jürgensen HJ, Pedersen F, Bechsgaard P, Hansen DA, Nielsen B, Pedersen-Bgergaard O, Rasmussen SL (1979) Effect of alprenolol on mortality amony patients with definite or suspected acute myocardial infarction. Preliminary results. Lancet 2: 865–868

    Google Scholar 

  68. Anturan Reinfarction Trial Research Group (1980) Sulfinpyrazon in the prevention of sudden death after myocardial infarction. New Engl J Med 302: 250–256

    Article  Google Scholar 

  69. Aspenström G, Korsan-Bengtsen K (1964) A double-blind study of dicumarol prophylaxis in coronary heart disease. Acta Med Scand 176: 563–575

    Article  Google Scholar 

  70. Aspirin Myocardial Infarction Study Research Group (1980) A randomized controlled trial of Aspirin in persons recovered from myocardial infarction. J Am Med Ass 243: 661–669

    Article  Google Scholar 

  71. Baber NS, Wainswright Evans O, Howitt G, Thomas M, Wilson C, Lewis JA, Dawes PM, Handler K, Tuson R (1980) Multicentre post infarction trial of propranolol in 49 hospitals in the United Kingdom, Italy, and Yugoslawia. Br Heart J 44: 96

    Google Scholar 

  72. Baroldi G (1976) Coronary thrombosis: facts and beliefs. Am Heart J 91: 683–688

    Article  PubMed  CAS  Google Scholar 

  73. Bigger JT, Heller CA, Wenger TL, Weld FM (1978) Risk stratification after acute myocardial infarction. Am J Cardiol 42: 202–210

    Article  PubMed  CAS  Google Scholar 

  74. Bolte HD (1980) Die Prognose des Myokardinfarktes. Internist 21: 685–690

    PubMed  CAS  Google Scholar 

  75. Boston Collaborative Drug Surveillance Group (1974) Regular aspirin intake and acute myocardial infarction. Br Med J 1: 440–443

    Article  Google Scholar 

  76. Breddin K (1980) Zum Wirkungsmechanismus and zur Dosierung thrombozytenfunktionshemmender Medikamente. In: Loew D (Hrsg) V. Colfarit Symposium, Schattauer, Stuttgart New York (im Druck)

    Google Scholar 

  77. Breddin K, Loew D, Lechner K, Iberia K, Walter E (1980) Secondary prevention of myocardial infarction. A comparison of acetylsalicylic acid, placebo and phenoprocoumon. Haemostasis 9: 325–344

    Google Scholar 

  78. Busse WD, Seuter F (1981) Erfahrungen mit Acetylsalicylsäure, Dipyridamol and Sulfinpyrazon in verschiedenen Tiermodellen. In: Breddin K, Gross D (Hrsg) Thrombosemodelle am Tier. Die Rolle der Prostaglandine für Thrombogenese and Schmerzpathogenese. Schattauer, Stuttgart New York (im Druck)

    Google Scholar 

  79. Canadian Cooperative Study Group (1978) A randomized trial of aspirin and sulfinpyrazone in threatened stroke. N Engl J Med 299: 53–59

    Article  Google Scholar 

  80. Clausen J, Felsby M, Jorgrensen FS, Nielsen BL, Roin J, Strange B (1966) Absence of prophylactic effect of propranolol in myocardial infarction. Lancet 2: 920–924

    Article  PubMed  CAS  Google Scholar 

  81. Coronary Drug Project Research Group (1976) Aspirin in coronary heart disease. J Clin Dis 29: 625–642

    Google Scholar 

  82. Ebert RV (1969) Longterm anticoagulant therapy after myocardial infarction. Final report of the veterans administration cooperative study. JAMA 207: 2263

    CAS  Google Scholar 

  83. Elwood PC, Cochrane AL, Burr ML, Sweetnam PM, Williams G, Welsby E, Hughes SJ, Renton R (1974) A randomized controlled trial of acetylsalicylic acid in the secondary prevention of mortality from myocardial infarction. Br Med J 2: 436–443

    Article  Google Scholar 

  84. Elwood PC, Sweetnam PM (1979) Aspirin and secondary mortality after myocardial infarction. Lancet 2: 1313–1315

    Article  PubMed  CAS  Google Scholar 

  85. Erhardt LR, Unge G, Boman G (1976) Formation of coronary arterial thrombi in relation to onset of necrosis in acute myocardial infarction in man. Am Heart J 91: 592–598

    Article  PubMed  CAS  Google Scholar 

  86. Green KG et al. (1975) Improvement in prognosis of myocardial infarction by long term ß-adreno-receptor blockade using practolol. Br Med J 3: 735–740

    Article  Google Scholar 

  87. Haarmann W (1981) Erfahrungen mit Azetylsalizylsäure, Dipyridamol and Sulfinpyrazon in verschiedenen Tiermodellen. In: Breddin K, Gross D (Hrsg) Thrombosemodelle am Tier. Die Rolle der Prostaglandine für Thrombogenese and Schmerzpathogenese. Schattauer, Stuttgart New York (im Druck)

    Google Scholar 

  88. Haerem JW (1974) Mural platelet microthrombi and major acute lesions of main epicardial arteries in sudden coronary death. Atherosclerosis 19: 529–541

    Article  PubMed  CAS  Google Scholar 

  89. Haerem JW (1971) Sudden coronary death: the occurence of platelet aggregates in the epicardial arteries of man. Atherosclerosis 14: 417–432

    Article  PubMed  CAS  Google Scholar 

  90. Hamberg MJ, Svensson B, Samuelson B (1974) Mechanism of the antiaggregating effect of aspirin in human platelets. Lancet 2: 223–224

    Article  PubMed  CAS  Google Scholar 

  91. Hammond EC, Garfinkel L (1975) Aspirin and coronary heart disease. Findings of a prospective study. Br Med J 2: 269–271

    Google Scholar 

  92. Harvald B, Hilden T, Lund E (1962) Long-term anticoagulant therapy after myocardial infarction. Lancet 2: 626–630

    Article  PubMed  CAS  Google Scholar 

  93. Hennekens CH, Karlson CK, Rosner B (1978) A case-control study of regular aspirin use and coronary deaths. Circulation 58: 35–38

    Article  PubMed  CAS  Google Scholar 

  94. Hoppe R (1980) Die Lebenserwartung nach Herzinfarkt aus der Sicht der Rentenversicherung. Z Kardiol 69: 494–498

    PubMed  CAS  Google Scholar 

  95. International Anticoagulant Review Group (1970) Collaborative analysis of long term anticoagulant administration after acute myocardial infarction. Lancet 1: 203–209

    Google Scholar 

  96. Loeliger EA, Hensen A, Kroes F, van Dijk

    Google Scholar 

  97. LM, Fekkes N, de Jonge H, Hemker HC (1967) A double-blind trial of longterm anticoagulant treatment after myocardial infarction. Acta Med Scand 182: 549–566

    Google Scholar 

  98. Luria MH, Knoke JD, Wachs JS, Luria MA (1978) Survival recovery from acute myocardial infarction. Am J Med 67: 7–14

    Article  Google Scholar 

  99. MacMillan RL, Brown KWH, Watt DL (1960) Long-term anticoagulant therapy after myocardial infarction. Can Med Assoc J 83: 567–570

    PubMed  CAS  Google Scholar 

  100. Manchester B (1964) Continuous anticoagulant therapy following myocardial infarction. Angiology 15: 19–26

    Article  PubMed  CAS  Google Scholar 

  101. Meuwissen OJAT, Vervoorn AC, Cohen O, Jordan FLJ, Nelemans FA (1969) Double blind trial of long-term anticoagulant treatment after myocardial infarction. Acta Med Scand 186: 361–368

    Article  PubMed  CAS  Google Scholar 

  102. Moncada S, Vane JR (1979) Arachidonic acid metabolites and the interactions between platelets and blood vessel walls. N Engl J Med 300: 1142–1147

    Article  PubMed  CAS  Google Scholar 

  103. Mustard JF, Rowsell HC, Murphy EA (1966) Platelet economy (platelet survival and turnover). Br J Haematol 12: 1–24

    Article  PubMed  CAS  Google Scholar 

  104. Pareti FS, Smith JB, Angelo AD, Mari D, Capitanio A, Manucci PM (1980) Congenital defiency of platelet-thromboxane and vascular wall prostacyclins in a patient with aspirin-like syndrome. In: Deutsch E, Lechner K (eds) Fibrinolyse, Thrombose, Haemostase. Schattauer, Stuttgart New York, pp 619–622 — 38.

    Google Scholar 

  105. Persantin-Aspirin Study Research Group (1980) Persantin and aspirin in coronary heart diesease. Circulation 62: 449–461

    Article  Google Scholar 

  106. Pietsch U, Lippmann M, Scharrer I, Breddin K (1977) Neue Befunde zur Wirkung von Azetylsalizylsäure. Die Hemmwirkung auf den Formwandel der Thrombozyten und ihre Bedeutung für die Dosierung als Antithrombotikum. In: Alexander K, Cachovan M (Hrsg) Diabetische Angiopathien. Witzstrock, Baden-Baden Köln New York, S 348–351

    Google Scholar 

  107. Ritland S, Lyngren T (1969) Comparison of efficiency of 3 and 12 months’ anticoagulant therapy after myocardial infarction. A controlled clinical trial. Lancet 1: 122–124

    Google Scholar 

  108. Roberts WC, Buja LM (1972) The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction. Am J Med 52: 425–443

    Article  PubMed  CAS  Google Scholar 

  109. Seaman AJ, Griswold HF, Reaume RB, Ritzmann L (1969) Longterm anticoagulant prophylaxis after myocardial infarction. Final report. N Engl J Med 281: 115–119

    Google Scholar 

  110. Seuter F (1976) Inhibition of platelet aggregation by acetylsalicylic acid and other inhibitors. Haemostasis 5: 85–95

    PubMed  CAS  Google Scholar 

  111. Silver MD, Baroldi G, Mariani F (1980) The relationship between acute occlusive coronary thrombi and myocardial infarction studied in 100 consecutive patients. Circulation 61: 219–227

    Article  PubMed  CAS  Google Scholar 

  112. Sinapius D (1972) Zur Morphologie verschiedener Koronarthromben. Dtsch Med Wochenschr 97: 544–551

    Article  PubMed  CAS  Google Scholar 

  113. Sixty Plus Reinfarction Study Research Group (1980) A doubleblind trial to assess long-term oral anticoagulant therapy in elderly patients after myocardial infarction. Lancet 2: 989–993

    Google Scholar 

  114. Steele PP, Carroll J, Overfield D et al. (1977) Effect of sulfinpyrazone on platelet survival time in patients with transient cerebral ischemic attacks. Stroke 8: 396–398

    Article  PubMed  CAS  Google Scholar 

  115. Steele PP, Weily H, Davies H (1975) Platelet survival time following aortic valve replacement. Circulation 51: 358–362

    Article  PubMed  CAS  Google Scholar 

  116. Vedin A, Wilhelmsson C, Elmfeld D, Säve-Söderbergh J, Tibblin G, Wilhelmsen L (1975) Deaths and nonfatal reinfarctions during two years’ follow up after myocardial infarction. Acta Med Scand 198: 353–364

    Article  PubMed  CAS  Google Scholar 

  117. Vogel G, Fischer C, Huyke R (1981) Reinfarktprophylaxe mit Azetylsalizylsäure. In: Loew D (Hrsg) V. Colfarit Symposium. Schattauer, Stuttgart New York (im Druck)

    Google Scholar 

  118. Weichert W, Wiedemann R, Breddin HK (1981) Versuche zur Standardisierung eines Tiermodells. Erzeugung laserinduzierter Thromben im Rattenmesenterium. 15. Angiologisches Symposium in Kitzbühel. Schattauer, Stuttgart New York (im Druck)

    Google Scholar 

  119. Wilhelmsson C, Vedin JA, Wilhelmsen L, Tibblin G, Werkö L (1974) Reduction of sudden deaths after myocardial infarction by treatment with Alprenolol. Lancet 2: 1157–1159

    Article  PubMed  CAS  Google Scholar 

  120. Working Party on anticoagulant therapy in coronary thrombosis (1964) An assessment of long-term anticoagulant administration after cardiac infarction. Br Med J 2: 837–843

    Article  Google Scholar 

  121. Zimmermann R (1981) Wirksamkeit anithrombotischer Substanzen an Modellen arterieller und venöser Thrombosen am Kaninchen. In: Breddin K, Gross D (Hrsg) Thrombosemodelle am Tier. Die Rolle der Prostaglandine für Thrombogenese und Schmerzpathogenese. Schattauer, Stuttgart New York (im Druck)

    Google Scholar 

  122. Alexander K, Buhl V, Holsten D, Poliwoda H, Wagner HH (1968) Fibrinolytische Therapie des chronischen Arterienverschlusses. Med Klin 63: 2067

    PubMed  CAS  Google Scholar 

  123. Copley AL (1979) Fibrin(ogen), Platelets and a new theory of Atherogenesis. Thromb Res 14: 249

    Article  PubMed  CAS  Google Scholar 

  124. Ehringer H, Fischer M, Lechner K, Mayrhofer E (1970) Thrombolytische Therapie nicht akuter arterieller Verschlüsse. Dtsch Med Wochenschr 95: 610

    Article  PubMed  CAS  Google Scholar 

  125. Ehringer H, Dudczak R, Lechner K, Widhalm F (1974) Streptokinasetherapie bei Gliedmaßenarterienverschlüssen. In: Schneider KW (Hrsg) Fibrinolytische Therapie. Med. Verlagsgesellschaft, Marburg, S 49

    Google Scholar 

  126. Ehringer H, Deutsch E, Hirsch M, Ingerle H, Konecny U, Minar E (1980) Urokinase (UK) in peripheral arterial occlusive disease (PAOD). In: Europ. UK Symposium (UK-Therapy) Mainz 1980. Abstract 28

    Google Scholar 

  127. European Cooperation Study Group (1979) Streptokinase in acute myocardial infarction. N Engl J Med 103: 797

    Google Scholar 

  128. Gottlob R. Die Grundlage für die Lyse alter Thromben. In: Pezold FA (Hrsg) Fibrinolyse-Therapie heute. Schattauer, Stuttgart New York S 43

    Google Scholar 

  129. Heinrich F, Schmutzler R, Braun H (1971) Die medikamentöse Eröffnung chronischer Gliedmaßenarterienverschlüsse. Therapiewoche 21: 1317

    Google Scholar 

  130. Heinrich F (1975) Streptokinase-Therapie chronisch arterieller Verschlußkrankheiten. Gelbe Hefte 15: 8

    Google Scholar 

  131. Hess H (1967) Thrombolytische Therapie. Schattauer, Stuttgart New York

    Google Scholar 

  132. Hess H, Mietaschk A, Ingrisch H (1980) Niedrig dosierte thrombolytische Therapie in Verbindung mit Katheterdilatation zur Wiederherstellung der Strombahn bei arteriellen Verschlüssen. Dtsch Ges f Angiologie, Abstract 34: 33

    Google Scholar 

  133. Hess H, Mietaschk A, Ingrisch H (1980) Niedrig dosierte thrombolytische Therapie zur Wiederherstellung der Strombahn bei arteriellen Verschlüssen. Dtsch Med Wochenschr 105: 787

    Article  PubMed  CAS  Google Scholar 

  134. Kirchhof B, van de Loo J (1980) Fibrinolytische Behandlung bei akutem Herzinfarkt. Hämostaseologie 1: 20

    Google Scholar 

  135. Martin M (1978) Application of streptokinase treatment in arterial occlusions. In: Martin M, Schoop W, Hirsh J (eds) New concepts in streptokinase dosimetry. Huber, Bern Stuttgart Vienna, p 180

    Google Scholar 

  136. Martin M, Heimburger N (1978) Clinical and laboratory findings in the course of activator (equimolar SK-plg complex) infusion. In: Martin M, Schoop W, Hirsh J (eds) New concepts in streptokinase dosimetry. Huber, Bern Stuttgart Vienna, p 169

    Google Scholar 

  137. Martin M, Roth F-J, Fiebach BJO, Auel H (1978) Fibrinolytische Therapie mit Aktivator. Dtsch Med Wochenschr 103: 1953

    Article  PubMed  CAS  Google Scholar 

  138. Müller-Fassbinder, Hess H (1975) Spätlysebehandlung chronischer arterieller Verschlüsse. Münch Med Wochenschr 117: 1461

    Google Scholar 

  139. Neuhof H, Hey D, Glaser E, Wolf H, Lasch HG (1975) Hemodynamic reactions induced by streptokinase therapy in patients with acute myocardial infarction. Eur J Intensive Care Med 1: 27

    Article  Google Scholar 

  140. Niessner H (1980) Urokinase-Therapie. In: Deutsch E, Lechner K (Hrsg) Fibrinolyse, Thrombose, Hämostase. Schattauer, Stuttgart New York, S 89

    Google Scholar 

  141. Oka SA (1976) Theoretical approach to the effect of shear stress on the development of atheroma. In: Copley AL, Okamoto S (eds) Hemorheology and Thrombosis. Pergamon Press, New York Oxford, p 305

    Google Scholar 

  142. Poliwoda H, Alexander K, Buhl V, Holsten D, Wagner HH (1969) Treatment of chronic arterial occlusions with streptokinase. N Engl J Med 280: 689

    Article  PubMed  CAS  Google Scholar 

  143. Rentrop P, Blanke H, Köstering H, Krasch KR (1980) Intrakoronare Streptokinase-Applikation bei akutem Infarkt und instabiler Angina pectoris. Dtsch Med Wochenschr 105: 221

    Article  PubMed  CAS  Google Scholar 

  144. Rentrop P, Blanke H, Karsch KR, Kaiser H, Köstering H, Leitz K (1981) Selective intracoronary thrombolysis in acute myocardial infarction and unstable angina pectoris. Circulation 63: 307

    Article  PubMed  CAS  Google Scholar 

  145. Schmutzler R (1969) Klinik der thrombolytischen Behandlung. Internist 10: 21

    PubMed  CAS  Google Scholar 

  146. Schoop W, Martin M, Zeitler E (1968) Beseitigung von Stenosen in Extremitätenarterien durch intravenöse Streptokinase-Therapie. Dtsch Med Wochenschr 35

    Google Scholar 

  147. Schoop W, Martin M, Zeitler E (1968) Beseitigung alter Arterienverschlüsse durch intravenöse Streptokinase-Infusion. Dtsch Med Wochenschr 48: 2321

    Article  Google Scholar 

  148. Schoop W (1970) Thrombolyse chronischer arterieller Stenosen und Verschlüsse. In: Pezold FA (Hrsg) Fibrinolyse-Therapie heute. Schattauer, Stuttgart New York, S 43

    Google Scholar 

  149. Cranley JJ (1972) Vascular Surgery. Harper and Row, New York, Evanston, San Francisco, London

    Google Scholar 

  150. Heberer G, Rau G, Schoop W (1974) Angiologie, 2. Aufl. Thieme, Stuttgart

    Google Scholar 

  151. Heyden B, Vollmar J (1979) Chirurgie kombinierter aortoiliakaler und femoro-poplitealer chronischer Arterienverschlüsse. Angio 1: 17–24

    Google Scholar 

  152. Vollmar J (1980) Reconstructive surgery of the arteries. Thieme-Stratton Inc., Stuttgart New York

    Google Scholar 

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Authors and Affiliations

  1. Patholog. Inst., Univ. Düsseldorf, Deutschland

    W. Hort

  2. Med. Kernklinik, Poliklinik im Univ.- Krankenhaus Hamburg-Eppendorf, Deutschland

    H. Greten

  3. Med. Klinik im Klinikum, Univ. Heidelberg, Deutschland

    G. Schettler

  4. Angiologische Abt., Dept für Innere Medizin, Poliklinik der Univ. Zürich, Deutschland

    A. Bollinger

  5. Abt. für Angiologie im Zentrum, Univ. Frankfurt, Deutschland

    H. K. Breddin

  6. Zentrum für Innere Medizin, Univ. Gießen, Deutschland

    H. G. Lasch & T. H. Schöndorf

  7. Emory University Hospital Atlanta, USA

    A. Grüntzig

  8. Med. Poliklinik der Charité, Berlin, Deutschland

    R. Brüschke

  9. Abt. für Herz- und Gefäßchirurgie und experimentelle Kardiologie, Univ.-Krankenhauses Hamburg-Eppendorf, Deutschland

    G. Rodewald, W. Rödiger & P. Kalmar

  10. Kardiolog. Abt. der Med. Klinik, Univ.-Krankenhauses Hamburg-Eppendorf, Deutschland

    D. Mathey

  11. Allg. Krankenhaus St. Georg, Hamburg, Deutschland

    H. Voss

  12. Abt. für Thorax- und Gefäßchirurgie, Dept. für Chirurgie, Univ. Ulm, Deutschland

    J. F. Vollmar

  13. Zentrum Innere Medizin II, Ulm, Deutschland

    G. Bode, E. Stange & H. Ditschuneit

  14. Oklahoma Medical Research Foundation, Oklahoma, Deutschland

    H. U. Klör

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  1. W. Hort
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  2. H. Greten
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K. Miehlke

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Hort, W. et al. (1981). Pathogenese, Prävention und Therapie der Arteriosklerose. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 87. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47092-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-47092-9_6

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