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Hepatologie

  • Conference paper
Verhandlungen der Deutschen Gesellschaft für innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für innere Medizin ((VDGINNERE,volume 87))

  • 31 Accesses

Zusammenfassung

Der Syntheseweg der Pyrimidinnukleotide und der entsprechenden Enzyme ist in den letzten Jahren intensiv untersucht worden [1–6].Die zytosolische, glutaminabhängige Carbamoylphosphatesynthetase (CPSase II, E.C. 6.3.5.5),die Aspartate-carbamoyltransferase (E.C. 2.1.3.2) und die Dihydroorotase (E.C. 3.5.2.3) sowie die Orotidine-5′-phosphate-pyrophosphate-phosphoribosyltransferase(OMPppase, E. C. 2.4.2.10) und die Orotidine-5′-phosphatedecarboxylase (E.C. 4.1.1.23)befinden sich im Zytosol in zwei Enzymkomplexen [7].

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Literatur

  1. Reichard P (1959) Adv Enzymo121: 263–294

    Google Scholar 

  2. Ito K, Nakamishi S, Terada M, Tatibana M (1970) Biochim Biophys Acta 220: 477–490

    Article  PubMed  CAS  Google Scholar 

  3. Bresnick E, Blatchford K (1964) Biochim Biophys Acta 81: 150–157

    CAS  Google Scholar 

  4. Bresnick E (1969) Adv Enzyme Regul 2: 213–236

    Article  Google Scholar 

  5. Creasey WA, Handschu-macher RE (1961) J Biol Chem 236: 2058–2063

    PubMed  CAS  Google Scholar 

  6. Appel SH (1968) J Biol Chem 243: 3924–3929

    PubMed  CAS  Google Scholar 

  7. Kavipurapu RR, Jones ME (1975) J Biol Chem 251: 5589–5599

    Google Scholar 

  8. Kennedy J (1973) Arch Biochem Biophys 157: 369–373

    Article  PubMed  CAS  Google Scholar 

  9. Jones ME (1971) Adv Enzyme Regul 9: 19–49

    Article  Google Scholar 

  10. Tatibana M, Shigesada K (1972) J Biochem 72: 549–560

    PubMed  CAS  Google Scholar 

  11. Tatibana M, Shigesada K (1972) Biochem Biophys Res Commun 46: 491–497

    Article  PubMed  CAS  Google Scholar 

  12. Rasenack J, Nowack J, Decker K (1978) Eur J Biochem 88: 475–482

    Article  PubMed  CAS  Google Scholar 

  13. Pausch J, Wilkening J, Nowack J, Decker K (1975) Eur J Biochem 53: 349–356

    Article  PubMed  CAS  Google Scholar 

  14. Berry MN, Friend DS (1969) J Cell Biol 43: 506–520

    Article  PubMed  CAS  Google Scholar 

  15. Atkinson D, Walton GM (1967) J Biol Chem 242: 3239–3241

    PubMed  CAS  Google Scholar 

  16. Hofmann F, Wilkening J, Nowack J, Decker K (1976) Hoppe Seylers Z Physiol Chem 357: 427–433

    Article  PubMed  CAS  Google Scholar 

  17. Keppler D In: Bergmeyer HU (Hrsg) Methoden der enzymatischen Analyse, 3. Aufl. Verlag Chemie, Weinheim, S 2238–2146

    Google Scholar 

  18. Hurlbert RB, Schmitz H, Brumm AF, Potter VR (1954) J Biol Chem 209: 23–39

    PubMed  CAS  Google Scholar 

  19. Wyatt GR (1951) Biochem J 48: 584–590

    PubMed  CAS  Google Scholar 

  20. Decker K, Keppler D, Pausch J (1973) Adv Enzyme Regul 11: 205–230

    Article  PubMed  CAS  Google Scholar 

  21. Berry M, Friend D (1969) High yield preparation of isolated rat parenchymal cells. J Cell Biol 43: 506–520

    Article  PubMed  CAS  Google Scholar 

  22. Exton J, Park C (1967) Control of gluconeogenesis in liver: 1.General features of gluconeogenesis in perfused livers of rats. J Biol Chem 242: 2622–2636

    PubMed  CAS  Google Scholar 

  23. Fröhlich J, Schollmeyer P, Gerok W (1978) Carbohydrate metabolism in renal failure. Am J Clin Nutr 31: 1541–1546

    PubMed  Google Scholar 

  24. Hörl WH, Stepinski J, Heidland A (1980) Carbohydrate metabolism and uraemia mechanisms for glycogenolysis and gluconeogenesis. Klin Wochenschr 58: 1051–1064

    Article  PubMed  Google Scholar 

  25. Rizzetto M, Canese MG, Aricó S, Crivelli O, Trepo C, Bonino F, Verme G (1977) Immunfluorescence detection of new antigen-antibody system (6/anti-6) associated to hepatitis B virus in liver and in serum of HBs-Ag carriers. Gut 18: 997

    Article  PubMed  CAS  Google Scholar 

  26. Rizzetto M, Purcell RH, Gerin JL (1980) Epidemiology of HBV-associated delta-agent: Geographical distribution of anti-delta and prevalence in polytransfused HBs-Ag carriers. Lancet 1: 1215

    Google Scholar 

  27. Purcell RH (1981) The hepatitis viruses an overview. The 1981 international symposium on viral hepatitis, New York 30.3.-2. 4. 1981

    Google Scholar 

  28. Rizzetto M (1981) Biology and characterization of the delta agent. The 1981 international symposium on viral hepatitis, New York 30. 3.-2. 4. 1981

    Google Scholar 

  29. Rizzetto M, Shih JWK, Gocke DJ, Purcell RH, Verme G, Gerin JL (1979) Incidence and significance of antibodies to delta antigen in hepatitis B virus infection. Lancet 2: 986

    Article  PubMed  CAS  Google Scholar 

  30. Walker JG, Doniach D, Roitt IM, Sherlock S (1965) Serological tests in diagnosis of primary biliary cirrhosis. Lancet 1: 827–831

    Article  PubMed  CAS  Google Scholar 

  31. Berg PA, Doniach D, Roitt IM (1967) Mitochondrial antibodies in primary biliary cirrhosis. I. Localization of the antigen to mitochondrial membranes. J Exp Med 126: 277–293

    Google Scholar 

  32. Miyachi K, Gupta RC, Dickson ER, Tan EM (1980) Precipitating antibodies to mitochondrial antigens in patients with primary biliary cirrhosis. Clin Exp Immunol 39: 599–606

    PubMed  CAS  Google Scholar 

  33. Berg PA, Binder T, Lindner H, Bannaski H, Maas D, Henning H, Brügel H (1975) Heterogenität mitochondrialer Autoantikörper. Dtsch Med Wochenschr 100: 1123–1127

    Article  PubMed  CAS  Google Scholar 

  34. Sayers TJ, Binder T, Berg PA (1979) Heterogeneity of anti-mitochondrial antibodies; characterization and separation of the antigen associated with the pseudolupus erythematosus syndrome. Clin Exp Immunol 37: 68–75

    PubMed  CAS  Google Scholar 

  35. Ben-Yoseph Y, Shapira E, Doniach D (1974) Further purification of the mitochondrial inner membrane autoantigen reacting with primary biliary cirrhosis sera. Immunology 26: 311–321

    PubMed  CAS  Google Scholar 

  36. Sharp HL (1976) Gastroenterology 70: 611

    PubMed  CAS  Google Scholar 

  37. Morse JO (1978) N Engl J Med 299: 1099 —3. Feldmann G, Martin JP, et al. (1975) Gut 16: 796

    Google Scholar 

  38. Liebermann J (1976) Ann Intern Med 100: 232

    Google Scholar 

  39. Hodges JR, Millward-Sadler GH, Barbatis C, Wright R (1981) N Engl J Med 304: 557

    Article  PubMed  CAS  Google Scholar 

  40. Weigand K (1977) Klin Wochenschr 55: 295

    Article  PubMed  CAS  Google Scholar 

  41. Weigand K, Alpert E, Keutmann H, Isselbacher KJ (1980) Comp Biochem Physiol [B] 67: 115

    Google Scholar 

  42. Schreiber G, Dryburgh H, Weigand K, Schreiber M, Witt J, Howlett G (1981) (eingereicht zur Publikation)

    Google Scholar 

  43. Eriksson S, Larsson C (1975) N Engl J Med 292: 176

    Article  PubMed  CAS  Google Scholar 

  44. Berk PD, Wolkoff AW, Scharschmidt BF, Schupeck M, Ketley JM, Waggoner JG, Jacoby WB (1977) Recent studies of the metabolism of conjugated bilirubin. In: Bianchi L, Gerok W, Sickinger K (eds) Liver and bile. MTP Press, pp 177–185

    Google Scholar 

  45. Goresky CA, Bach G, Nadeau BE (1973) On the uptake of materials by the intact liver; the transport and net removal of galactose. J Clin Invest 52: 991–998

    Article  PubMed  CAS  Google Scholar 

  46. Scharschmidt BF, Waggoner JG, Berk PD (1975) Hepatic organic anion uptake in the rat. J Clin Invest 56: 1280–1292

    Article  PubMed  CAS  Google Scholar 

  47. Wolkoff AW, Goresky CA, Sellin J, Gatmaitan Z, Arias IM (1979) Role of ligandin in transfer of bilirubin from plasma into liver. Am J Physiol 236: E638 — E648

    PubMed  CAS  Google Scholar 

  48. Chao Y-s, Jones AL, Hradek GT, Windier EET, Havel RJ (1981) Autoradiographic localization of the sites of uptake, cellular transport, and catabolism of low density lipoproteins in the liver of normal and estrogen-treated rats. Proc Natl Acad Sci USA 78: 597–601

    Article  PubMed  Google Scholar 

  49. Windier EET, Kovanen PT, Chao Y-s, Brown MS, Havel RJ, Goldstein JL (198Oa) The estradiol-stimulated lipoprotein receptor of rat liver. J Biol Chem 255: 10464–10471

    Google Scholar 

  50. Windier EET, Chao Y-s, Havel RJ (198Ob) Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat. J Biol Chem 255: 5475–5480

    Google Scholar 

  51. Windier EET, Chao Y-s, Havel RJ (198Oc) Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. J Biol Chem 255: 8303–8307

    Google Scholar 

  52. McMahon B, Yen S, Trichopoulos D, Warren K, Nardi G (1981) Coffee and cancer of the pancreas. N Engl J Med 304: 630–633

    Article  Google Scholar 

  53. Desmond PV, Patwardhan PV, Johnson RF, Schenker S (1980) Impaired elimination of caffeine in cirrhosis. Dig Dis Sci 25: 193–197

    Article  PubMed  CAS  Google Scholar 

  54. Parsons WD, Neims AH (1978) Effect of smoking on caffeine clearance. Clin Pharmacol Ther 24: 40–45

    PubMed  CAS  Google Scholar 

  55. Lauterburg B, Bircher J (1976) Expiratory measurement of maximal aminopyrine demethylation in vivo. Effect of phenobarbital, partial hepatectomy, portacaval shunt and bile duct ligation in the rat. J Pharmacol Exp Ther 196: 501–509

    Google Scholar 

  56. Welch RM, Hsu SY, DeAngelis RC (1977) Effect of Aroclor 1254, phenobarbital and polycyclic aromatic hydrocarbons on the plasma clearance of caffeine in the rat. Clin Pharmacol Ther 22: 791–798

    PubMed  CAS  Google Scholar 

  57. Aldrige A, Parsons WD, Neims AH (1977) Stimulation of caffeine metabolism in the rat by 3-methylcholanthrene. Life Sci 21: 967–974

    Article  Google Scholar 

  58. McIntosh PR, Peacock AC, Gelboin HV (1980) The induction of liver microsomal proteins by 3-methylcholanthrene in rats of different age, sex and strain. Biochem Biophys Acta 627: 290–300

    Article  PubMed  CAS  Google Scholar 

  59. Nebert DW, Winker J, Gelboin MV (1969) Aryl hydrocarbon hydroxylase activity in human placenta from cigarette smoking and nonsmoking women. Cancer Res 29: 1763 —1769

    Google Scholar 

  60. Gerok W (1963) Verh Dtsch Ges Inn Med 69: 426

    CAS  Google Scholar 

  61. Denkla WD, Dewey HK (1967) J Lab Clin Med 69: 160

    Google Scholar 

  62. Bloxa DL, Warren WH (1974) Analyt Biochem 60: 621

    Article  Google Scholar 

  63. Holm E (1977) In: Wewalka (Hrsg) 3. Internationales Ammoniak-Symposium. Fischer, Stuttgart

    Google Scholar 

  64. Riderer P, et al. (1978) Gastroenterol 12: 768

    Google Scholar 

  65. Smith AP, et al. (1978) Ann Surg 187: 343

    Article  PubMed  CAS  Google Scholar 

  66. Ferenci P (1977) In: Wewalka (Hrsg) 3. Internationales Ammoniak-Symposium. Fischer, Stuttgart

    Google Scholar 

  67. Fischer JE, et al. (1975) Surgery 78: 276

    PubMed  CAS  Google Scholar 

  68. Fischer JE, et al. (1974) Am J Surg 127: 40

    Article  PubMed  CAS  Google Scholar 

  69. Van Caulaert C, Deviller C (1932) Ammoniémie expérimentale après ingéstion de chloruré d’ammonium chez l’homme a l’état normal et pathologique. CR Soc Biol 111: 50

    Google Scholar 

  70. Eiseman B, Lindeman GM, Clark GM (1956) Clinical evaluation of the ammonium citrate tolerance test for determining the patency of a portacaval shunt. J Lab Clin Med 48: 579

    PubMed  Google Scholar 

  71. Egense J (1960) Ammonium tolerance test. A diagnostic aid in liver diseases. Acta Med Scand 167: 53

    Article  PubMed  CAS  Google Scholar 

  72. Hennrich G (1962) Klinische Erfahrungen mit der Ammoniumchloridbelastung beim Pfortaderhochdruck, insbesondere als Funktionstest porto-kavaler Anastomosen. Acta Hepatogastroenterol (Stuttg) 9: 1

    CAS  Google Scholar 

  73. Conn HO (1973) Ammonia tolerance in assessing the patency of portacaval anastomoses. A long-term controlled investigation. Arch Intern Med 131: 221

    Article  PubMed  CAS  Google Scholar 

  74. Drapanas T, LoCicero J, Dowling JB (1975) Hemodynamics of the interposition mesocaval shunt. Ann Surg 181: 523

    Article  PubMed  CAS  Google Scholar 

  75. Reichle FA, Owen OE (1979) Hemodynamic patterns in human hepatic cirrhosis. A prospective randomized study of the hemodynamic sequelae of distal splenorenal and mesocaval shunts. Ann Surg 190: 523

    Google Scholar 

  76. Swan KG, Howard MM, Rocko JM, Rush BF, Timmes JJ, Leevy CM (1980) Operative vasopressin and mesocaval shunting for portal hypertension. Surgery 87: 46

    PubMed  CAS  Google Scholar 

  77. Halbfass HJ, Herz R (1981) Ergebnisse des mesocavalen Shunts. In: Paquet KJ, Denck H (Hrsg) Diagnose und Therapie der Oesophagusvarizenblutung (im Druck )

    Google Scholar 

  78. Da Fonseca-Wollheim F (1973) Bedeutung von Wasserstoffionenkonzentration und ADP-Zusatz bei der Ammoniakbestimmung mit Glutamatdehydrogenase. J Clin Chem Clin Biochem 11: 421

    Google Scholar 

  79. Herz R, Halbfass HJ, Rössle M, Mathias K, Herrmann D, Gerok W (1980) Frühveränderungen von Leberhämodynamik und -funktion nach mesocavalem Shunt. Verh Dtsch Ges Inn Med 86: 780

    Google Scholar 

  80. Tygstrup N (1966) Determination of the hepatic elimination capacity (Lm) of galactose by single injection. J Clin Invest 39: 118

    Google Scholar 

  81. Bircher J, Blankart R, Halpern A, Häcki W, Laissue J, Preisig R (1973) Criteria for assessment of functional impairment in patients with cirrhosis of the liver. Eur J Clin Invest 3: 72

    Article  PubMed  CAS  Google Scholar 

  82. Herz R, Schulte U, Rössle M, Gerok W (1979) Die quantitative Beurteilung der Leberfunktion mit dem vereinfachten Dimethylaminoantipyrin-Atemtest: Ein Vergleich mit Galaktose-Eliminationskapazität, BSP-Clearance und konventionellen Leberfunktionsproben bei Leberzirrhose. Verh Dtsch Ges Inn Med 85: 485

    Google Scholar 

  83. Warren KS, Reboucas G, Baptista G (1965) Ammonia metabolism and hepatic coma in hepatosplenic schistosomiasis. Patients studied before and after portacaval shunt. Ann Intern Med 62: 1113

    Google Scholar 

  84. Bonati M, Latini R, Marzi E, Cantoni R, Belvedere G (1980) 2–14C-caffeine metabolism in control and 3-methyl-cholanthrene induced rat liver microsomes by high pressure liquid chromatography. Toxicol Lett 7: 1–7

    Google Scholar 

  85. Domschke W (1977) Perspektiven gastrointestinaler Hormone. Dtsch Ärztebl 2789–2794

    Google Scholar 

  86. Grün M, Liehr H, Rasenack U, Thiel H (1977) Die modifizierte portokavale Anastomose der Ratte. Verh Dtsch Ges Inn Med 83: 507–511

    PubMed  Google Scholar 

  87. Grün M (1978) Biologische Auswirkungen einer portokavalen Anastomose. Verh Physikal Med Ges 87: 1–19

    Google Scholar 

  88. Grün M, Heine WD (1980) Einfluß des venösen Pankreasblutes auf das zytologische Bild der Hepatozyten nach portokavalen Anastomosen. Aktuel Endokrinol Stoffwechsel 1: 175

    Google Scholar 

  89. Grün M, Liehr H, Heine WD, Rasenack U (1980) Liver hyperregeneration after end-to-side portacaval anastomosis as a consequence of lack of cell differentiation control by factors originating from the upper intestinal tract. In: Lie TS (ed) Microsurgery. Excerpta Medica, London Amsterdam, pp 453–456

    Google Scholar 

  90. Grün M, Richter E, Heine WD (1981) Renal bile acid excretion as a cause of neoplastic lesions in the urinary tract after total portacaval shunt in the normal rat. Acta Hepatogastroenterol (Stuttg) (in press)

    Google Scholar 

  91. Heine WD, Grün M, Rasenack U, Liehr H (1979) Präneoplastische und neoplastische Urothelveränderungen nach portocavaler Anastomose der Ratte. Verh Dtsch Ges Pathol 63: 517

    Google Scholar 

  92. Heine WD (1981) Hepatozelluläre Reaktionen auf qualitative und quantitative Änderungen der Blutversorgung. In: Tittor W, Schwalbach G (Hrsg) Leberdurchblutung und Kreislauf. Thieme, Stuttgart New York, S 35–48

    Google Scholar 

  93. Putnam CW, Porter KA, Starzl ThE (1976) Hepatic encephalopathy and light and electron micrographic changes of the baboon liver after portal diversion. Ann Surg 184: 155–161

    Article  PubMed  CAS  Google Scholar 

  94. Richter E, Hofstetter GJ, Seifert H (1979) Intravenöse und orale Galaktosebelastung bei Ratten mit Galaktosaminhepatitis und ANIT-Cholestase. Z Gastroenterol 17: 713–721

    PubMed  CAS  Google Scholar 

  95. Rubin E, Hutterer F, Ohshiro J, Jacobson JH (1968) Effect of experimental portacaval shunt on hepatic drug metabolizing enzymes. Proc Soc Exp Biol Med 127: 444–447

    Article  PubMed  CAS  Google Scholar 

  96. Starzl ThE, Watanabe K, Porter KA, Putnam CW (1976) Effects of insulin, glucagon and insulin/glucagon infusion on liver morphology and cell division after complete portacaval shunt in dogs. Lancet 1: 821–825

    Article  PubMed  CAS  Google Scholar 

  97. Terlunen E, Altenähr E, Becker K, Ossenberg FW (1977) Liver atrophy following portacaval shunt in normal rats a morphometric study —. Res Exp Med (Berl) 170: 133–142

    Article  CAS  Google Scholar 

  98. Kakis G, Yousef IM (1980) Gastroenterology 78: 1402–1411

    PubMed  CAS  Google Scholar 

  99. Kakis G, Phillips MJ, Yousef IM (1980) Lab Invest 43: 73–80

    PubMed  CAS  Google Scholar 

  100. Schölmerich J, Kremer B, Schmidt K, Setyadharma H, Richter IE, Schoenenberger GA (1980) Langenbecks Arch Chir 350: 151–163

    Article  PubMed  Google Scholar 

  101. Kremer B, Allgöwer M, Liebermann D, Scheidegger AM, Schölmerich J, Schweitzer A, Wüst B, Schoenenberger GA (1979) Scand J Plast Reconstr Surg 13: 217–222

    Article  PubMed  CAS  Google Scholar 

  102. Gutmann I, Bergmeyer HU (1974) In: Bergmeyer HU (Hrsg) Methoden der enzymatischen Analyse, 3. Aufl. Verlag Chemie, Weinheim

    Google Scholar 

  103. Schölmerich J, Kremer B, Schmidt K, Setyadharma H, Richter IE, Schoenenberger GA (1981) Horm Metab Res (in press)

    Google Scholar 

  104. Bojar H, Balzer L, Reiners K, Basler M, Reipen W, Staib W (1975) J Clin Chem Clin Biochem 13: 25–30

    CAS  Google Scholar 

  105. Petzinger E, Seeger R (1976) Naunyn-Schmiedebergs Arch Pharmacol 295: 211–213

    Article  PubMed  CAS  Google Scholar 

  106. Schölmerich J, Schmidt K, Kremer B, Becher M-S, Gerok W (1981) Klin Wochenschr (im Druck )

    Google Scholar 

  107. Schmidt K, Rogg T, Rodloff C, Schölmerich J (in Vorbereitung)

    Google Scholar 

  108. Lehnert T, Berlet HH (1979) Biochem J 177: 813–816

    PubMed  CAS  Google Scholar 

  109. Kroes J, Ostwald R, Keith A (1972) Biochim Biophys Acta 274: 71–74

    Article  PubMed  CAS  Google Scholar 

  110. Bianchi L (1979) Verh Dtsch Ges Inn Med 85: 362–365

    Google Scholar 

  111. Phillips MJ, Oda M, Funatsu K (1978) Am J Pathol 93: 729–744

    PubMed  CAS  Google Scholar 

  112. Abberger H, Bickel U, Buscher P, Fuchte K, Gerok W, Kramer W, Kurz G (1980) VI. Intern. Bile Acid. Meeting, Bile Acids and Lipids, Freiburg. MTP-Press Ltd., Lancester (in press)

    Google Scholar 

  113. Matern S, Gerok W (1979) Pathophysiology of the enterohepatic circulation of bile acids. Rev Physiol Biochem Pharmacol 85: 125–204

    Article  PubMed  CAS  Google Scholar 

  114. Back P, Spaczinski K, Gerok W (1974) Bile salt glucuronides in urine. Hoppe-Seylers Z Physiol Chem 355: 749–755

    PubMed  CAS  Google Scholar 

  115. Matern H, Matern S, Schelzig Ch, Gerok W (1980) Bile acid UDP-glucuronyltransferase from human liver. Properties ans studies on aglycone substrate specificity. FEBS Lett 118: 251–254

    Google Scholar 

  116. Black M, Billing BH, Heirwegh KPM (1970) Determination of bilirubin UDP-glucuronyltransferase activity in needlebiopsy specimens of human liver. Clin Chim Acta 29: 27–35

    Article  PubMed  CAS  Google Scholar 

  117. Bennion LJ, Grundy SM (1978) Risk factors in the development of cholelithiasis in man. N Engl J Med 299: 1161–1167, 1221–1227

    Google Scholar 

  118. Grundy SM, Metzger AL (1972) A physiologic method for estimation of hepatic secretion of biliary lipids in man. Gastroenterology 62: 1200–1217

    PubMed  CAS  Google Scholar 

  119. Paumgartner G, Horak W, Probst P, Grabner G (1971) Effect of phenobarbital on bile flow and bile salt excretion in the rat. Naunyn-Schmiedebergs Arch Pharmacol 270: 98–103

    Article  PubMed  CAS  Google Scholar 

  120. Bartlett GR (1959) Phosphorus assay in column chromatography. J Biol Chem 234: 466–470

    PubMed  CAS  Google Scholar 

  121. Leiß O, Murawski U, Egge H (1979) Mikrobestimmung von Lipoproteinlipiden im Serum. J Clin Chem Clin Biochem 17: 619–625

    PubMed  Google Scholar 

  122. Albers JJ, Cheung MC, Hazzard WR (1978) High-density lipoproteins in myocardial infarction survivors. Metabolism 27: 479–485

    Article  PubMed  CAS  Google Scholar 

  123. Williams P, Robinson D, Bailey A (1979) High-density lipoprotein and coronary risk factors in normal men. Lancet 1: 72–75

    Article  PubMed  CAS  Google Scholar 

  124. Miller NE, Nestel PJ, Clifton-Bligh P (1976) Relationships between plasma lipoprotein cholesterol concentrations and the pool size and metabolism of cholesterol in man. Atherosclerosis 23: 535–547

    Article  PubMed  CAS  Google Scholar 

  125. Small DM (1971) Prestone gallstone disease

    Google Scholar 

  126. is therapy safe? N Engl J Med 284: 214–216

    Google Scholar 

  127. Alter H, Holland P, Purcell R, Popper H (1978) Transmissible agent in Non-A, Non-B hepatitis. Lancet 1: 459–463

    Google Scholar 

  128. Dienstag J, Alaama A, Mosley J, Redeker A, Purcell R (1977) Etiology of sporadic hepatitis B surface antigen

    Google Scholar 

  129. negative hepatitis. Ann Intern Med 87: 1–6

    Google Scholar 

  130. Müller R, Willers H, Knocken KW, Sipos S, Höpken W (1979) Epidemiologie und Prognose der Hepatitis Non-A, Non-B. Dtsch Med Wochenschr 104: 1471–1474

    Google Scholar 

  131. Prince AM, Brotman B, Grady GF, Kuhns WJ, Hazzi C, Levine RW, Millian SJ (1974) Long-incubation post-transfusion hepatitis without serological evidence of exposure to hepatitis B virus. Lancet 2: 241–246

    Article  PubMed  CAS  Google Scholar 

  132. Shimizu YK, Feinstone SM, Purcell RH, Alter HJ, London WT (1979) Non-A, Non-B hepatitis: ultrastructural evidence for two agents in experimentally infected chimpanzees. Science 205: 197–200

    Article  PubMed  CAS  Google Scholar 

  133. Tabor W, Drucker J, Hoofnagle J, April M, Gerety R, Seeff L, Jackson D, Barker L, Pineda-Tamongong G (1978) Transmission of Non-A, Non-B hepatitis from man to chimpanzees. Lancet 1: 463–465

    Google Scholar 

  134. Tabor E, Peterson DA, April M, Seeff L, Gerety RJ (1980) Transmission of human Non-A, Non-B hepatitis to chimpanzees following failure to transmit GB agent virus. J Med Virol 5: 103–108

    Google Scholar 

  135. Tsiquaye KN, Bird RG, Tovey G, Wyke J, Williams R, Zuckerman AJ (1980) Further evidence of cellular changes associated with Non-A, Non-B hepatitis. J Med Virol 5: 63–71

    Google Scholar 

  136. Beam AG, Kunkel HG, Slater RJ (1956) The problem of chronic liver disease in young women. Am J Med 21: 3

    Article  Google Scholar 

  137. Behrens UJ, Hollander VP (1976) Cell membrane sialoglycopeptides of corticoid-sensitive and -resistant Lymphosarkoma P 1798. Cancer Res 36: 172–180

    PubMed  CAS  Google Scholar 

  138. Berg PA, Doniach D, Roitt IR (1967) Mitochondrial antibodies in primary biliary cirrhosis. I. Localization of the antigen to mitochondrial membranes. J Exp Med 126: 277

    Google Scholar 

  139. Berg PA, Brandt H (1974) Die chronisch-aggressive (lupoide) Hepatitis: Diagnose, Differentialdiagnose and Therapie. Therapiewoche 24: 521

    Google Scholar 

  140. Berg PA, Sayers T, Wiedmann KH, Klöppel G (1980) Serological classification of chronic cholestatic liver disease by the use of two different types of antimitochondrial antibodies. Lancet 2: 1329–1332

    Article  PubMed  CAS  Google Scholar 

  141. Blobel G, Potter VR (1966) Nuclei from rat liver: Isolation method that combines purity with high yield. Science 154: 1662–1665

    Google Scholar 

  142. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248–254

    Article  PubMed  CAS  Google Scholar 

  143. Dallner G (1978) In: Fleischer S, Packer L (eds) Isolation of microsomal subfractions by use of density gradients. Methods Enzymol 52: 71–83

    Google Scholar 

  144. Hopf U, Meyer zum Büschenfelde KH, Arnold W (1976) Detection of a liver-membrane autoantibody in HBs Ag-negative chronic active hepatitis. N Engl J Med 294: 578–582

    Article  PubMed  CAS  Google Scholar 

  145. Mackay IR, Ritts RE (1979) WHO Handbook of Immunological Techniques. WHO Geneva

    Google Scholar 

  146. McFarlane IG, Wojcicka BM, Zucker GM, Eddleston ALWF, Williams R (1977) Purification and characterization of human liver-specific membrane lipoprotein ( LSP ). Clin Exp Immunol 27: 381–390

    Google Scholar 

  147. Miyachi K, Gupta RC, Dickson ER, Tan EM (1980) Precipitating antibodies to mitochondrial antigens in patients with primary biliary cirrhosis. Clin Exp Immunol 39: 599–606

    PubMed  CAS  Google Scholar 

  148. Rizzetto M, Swana G, Doniach D (1973) Microsomal antibodies in active chronic hepatitis and other disorders. Clin Exp Immunol 15: 331–344

    PubMed  CAS  Google Scholar 

  149. Scherbaum WA, Berg PA (1981) Bedeutung von Autoantikörpern in der Diagnostik endokrinologischer Erkrankungen. Dtsch Med Wochenschr 106: 308–313

    Article  PubMed  CAS  Google Scholar 

  150. Spudich JA, Watt S (1971) The regulation of rabbit skeletal muscle contraction. J Biol Chem 246: 4866–4871

    PubMed  CAS  Google Scholar 

  151. Toh BH (1979) Smooth muscle autoantibodies and autoantigens. Clin Exp Immunol 38: 621

    PubMed  CAS  Google Scholar 

  152. Whitaker JR (1963) Determination of molecular weights of proteins by gel filtration on Sephadex. Anal Chem 35: 1950–1953

    Article  CAS  Google Scholar 

  153. Wiedmann KH, Melms A, Berg PA (1981) Anti-Aktinantikörper vom IgG- und IgM-Typ bei hepatischen und nichthepatischen Erkrankungen. Verh Dtsch Ges Inn Med 87 (im Druck)

    Google Scholar 

  154. Burch ER, Sullivan JF (1976) Diagnosis of zinc, copper, and manganese abnormalities in man. Trace elements. Med Clin Nath Am 60: 655–660

    Google Scholar 

  155. Hanisch P (1981) Spurenelementbestimmung mittels protoneninduzierter Röntgenfluoreszenzanalyse (PIXE) in der Leber bei alkoholischen und nichtalkoholischen chronischen Lebererkrankungen sowie bei Lebertumoren. Dissertation, FB Humanmedizin der Universität Marburg (in Vorbereitung)

    Google Scholar 

  156. Hasselmann J, Koenig W, Richter FW, Bode JCh, Ohta W (1977) Application of PIXE to trace element analysis in biological tissues. Nucl Instr Meth 142: 163–169

    Article  CAS  Google Scholar 

  157. Herkel W (1931) Über die Bedeutung des Kupfers (Zinks und Mangans) in der Biologie und Pathologie. Beitr Pathol 85: 513–554

    Google Scholar 

  158. Hunt AH, Parr RM, Taylor DM, Trott NG (1963) Relation between cirrhosis and trace metal content of liver with special reference to primary biliary cirrhosis and copper. Br Med J 2: 1498–1501

    Article  PubMed  CAS  Google Scholar 

  159. Koenig W, Richter FW, Meinel B, Bode JC (1979) Variation of trace element contents in a single human liver. J Clin Chem Clin Biochem 17: 23–27

    PubMed  CAS  Google Scholar 

  160. Lundvall O, Weinfeld A, Lundin P (1969) Iron stores in alcohol abusers. Acta Med Scand 185: 259–269

    Article  PubMed  CAS  Google Scholar 

  161. Lundin P, Lundvall O, Weinfeld A (1971) Iron storage in alcoholic fatty liver. Acta Med Scand 189: 541–546

    Article  PubMed  CAS  Google Scholar 

  162. Meinel B, Bode JC, Koenig W, Richter FW (1979) Study of sample collection and preparation methods for multi element analysis in liver tissue by proton induced X-ray emmission ( PIXE ). J Clin Chem Clin Biochem 17: 15–21

    Google Scholar 

  163. Meinel B, Bode JC, Koenig W, Richter F-W (1979) Contents of trace elements in the human liver before birth. Biol Neonate 36: 225–232 —

    Google Scholar 

  164. Ritland S, Steinnes E, Skrede S (1977) Hepatic copper content, urinary copper excretion and serum ceruloplasmin in liver disease. Scand J Gastroenterol 12: 81–88

    PubMed  CAS  Google Scholar 

  165. Sullivan JF, Burch RE (1976) Potential role of zinc in liver disease. In: Prasad AS (ed) Trace elements and human disease, vol 1, 2. Academic Press, New York

    Google Scholar 

  166. Hoensch H, Hartmann F, Schomerus H, Bieck P, Dölle W (1979) Monooxygenase enzyme activity in alcoholics with varying degrees of liver damage. Gut 20: 666–672

    Article  PubMed  CAS  Google Scholar 

  167. Bock KW, Brunner G, Hoensch H, Huber E, Josting D (1978) Determination of microsomal UDP-glucuronyltransferase in needle-biopsy specimens of human liver. Eur J Clin Pharmacol 14: 367–373

    Article  PubMed  CAS  Google Scholar 

  168. Hoensch H, Woo CH, Raffin SB, Schmid R (1976) Oxidative metabolism of foreign compounds in rat small intestine: cellular localization and dependence on dietary iron. Gastroenterology 70: 1064–1070

    Google Scholar 

  169. Gundert-Remy U, Marquardt R, Andritsch F, Weber E (1975) Veränderungen der Halbwerts-Zeit von Antipyrin und Tolbutamid bei chronischen Alkoholikern im Verlauf der Entzugs-Therapie. Inn Med 2: 67–72

    Google Scholar 

  170. Bode JCh (1980) Alcohol and the gastrointestinal tract. Ergeb Inn Med Kinderheilk 45: 1–75

    CAS  Google Scholar 

  171. Bode JCh, Bode Ch, Kugler V (1981) Bacterial toxins and liver fibrosis. In: Gerlach U, Pott G, Voss B, Rauterberg J (eds) Connective tissue of the normal and fibrotic human liver. Thieme, Stuttgart (in press)

    Google Scholar 

  172. DuBose DA, Lemaire M, Basamania K, Rowlands J (1980) Comparison of plasma extraction techniques in preparation of samples for endotoxin testing by the Limulus amoebocyte lysate test. J Clin Microbiol 11: 68–72

    PubMed  CAS  Google Scholar 

  173. Levin J, Tomasulo PA, Oser RS (1970) Detection of endotoxin in human blood and demonstration of an inhibitor. J Lab Clin Med 75: 903–911

    PubMed  CAS  Google Scholar 

  174. Liehr H, Grün M, Brunswig D, Sautter Th (1976) Endotoxinämie bei Leberzirrhose. Gastroenterology 1: 14–23

    Google Scholar 

  175. Nolan JP (1975) The role of endotoxin in liver injury. Gastroenterology 69: 1346–1356

    PubMed  CAS  Google Scholar 

  176. Nolan JP (1979) The contribution of gut-derived endotoxins to liver injury. Yale J Biol Med 52: 127–133

    PubMed  CAS  Google Scholar 

  177. Prytz H, Holst-Christensen J, Korner B, Liehr H (1976) Portal venous and systemic endotoxinaemia in patients without liver disease and systemic endotoxinaemia in patients with cirrhosis. Scand J Gastroenterol 11: 857–863

    PubMed  CAS  Google Scholar 

  178. Reinhold RB, Fine J (1971) A technique for quantitative measurement of endotoxin in human plasma. Proc Soc Exp Biol Med 137: 304–340

    Article  Google Scholar 

  179. Stefenelli N (Persönl. Mitteilung)

    Google Scholar 

  180. Tarao K, So K, Moroi T, Ikeuchi T, Suyama T, Endo O, Fukushima K (1977) Detection of endotoxin in plasma and ascitic fluid of patients with cirrhosis: its clinical significance. Gastroenterology 73: 539–542

    PubMed  CAS  Google Scholar 

  181. Creutzfeld W, Frerichs H, Kraft W (1969) Acta Diabetol Lat [Suppl I] 4: 205

    Google Scholar 

  182. Megyesi G, Samols E, Marks V (1967) Lancet 2: 1051

    Article  PubMed  CAS  Google Scholar 

  183. Kremer GJ, Atzpodien W, Jacobi H, Friedrichs U, Friedrichs M (1976) Inn Med 3: 267

    Google Scholar 

  184. Oehler G, Bleyl H, Matthes K (1978) Med Welt 29: 1314

    PubMed  CAS  Google Scholar 

  185. Oehler G, Bleyl H, Knecht M, Matthes K (1981) Z Gastroenterol 19: 26

    PubMed  CAS  Google Scholar 

  186. Creutzfeld W, Sickinger K, Frerichs H (1971) In: Pfeiffer EF (Hrsg) Handbuch des Diabetes mellitus, Bd II. Lehmann, München, S 807

    Google Scholar 

  187. Johnston DG, Alberti KGMM, Wright R, Smith-Laing G, Stewart AM, Sherlock S, Faber 0, Binder C (1978) Diabetes [Suppl 1] 27: 201

    CAS  Google Scholar 

  188. Klein B, Morgenstern S, Kaufmann JH (1966) Clin Chem 12: 816

    PubMed  CAS  Google Scholar 

  189. Wide L, Axen R, Porath J (1967) Immunochemistry 4: 381

    Article  CAS  Google Scholar 

  190. Heding LG (1975) Diabetologia 11: 541

    Article  PubMed  CAS  Google Scholar 

  191. Collins JR, Crofford DB (1969) Arch Intern Med 124: 142

    Article  PubMed  CAS  Google Scholar 

  192. Rehfeld JF, Juhl E, Hilden M (1973) Gastroenterology 64: 445

    PubMed  CAS  Google Scholar 

  193. Waldhäusl W, Irsigler K (1969) Wien Klin Wochenschr 81: 544

    PubMed  Google Scholar 

  194. Mating D, Kaufmann M (1975) Manch Med Wochenschr 117: 1689

    Google Scholar 

  195. Megyesi G, Samols E, Marks V (1967) Lancet 2: 1051

    Article  PubMed  CAS  Google Scholar 

  196. Blackard WG, Nelson NC (1970) Diabetes 19: 302

    PubMed  CAS  Google Scholar 

  197. Waldhäusl W, Wewalka F (1966) Wien Klin Wochenschr 78: 734

    PubMed  Google Scholar 

  198. Katz AJ, Rubenstein AH (1973) J Clin Invest 52: 1113

    Article  PubMed  CAS  Google Scholar 

  199. Ishii H, Mamori H, Takahashi H, Muraoka M, Arai M, Shigeta Y, Saito H, Tsuchiya M (1975) Leber Magen Darm 5: 52

    Google Scholar 

  200. Johnston DG, Alberti KGMM, Faber OK, Binder C, Wright R (1977) Lancet 1: 10

    Article  Google Scholar 

  201. Kawai K, Hayakawa H, Yoshida K, Shimizu M, Noto Y, Ohno T, Morita N, Hattori N (1977) Diabete Metab 3: 7

    PubMed  CAS  Google Scholar 

  202. Iwasaki Y, Ohkubo A, Kajinuma H, Akanuma Y, Kosaka K (1978) J Clin Endocrinol Metab 47: 774

    Article  PubMed  CAS  Google Scholar 

  203. Smith-Laing G, Sherlock S, Faber OK (1979) Gastroenterology 76: 685

    PubMed  CAS  Google Scholar 

  204. Iwasaki Y, Sato H, Ohkubo A, Sanjo T, Futagawa S, Sugiura M, Tsuji S (1980) Gastroenterology 78: 677

    PubMed  CAS  Google Scholar 

  205. Boyer TD, Reynolds TB (1976) Prostaglandin insufficiency: A role in the hepatorenal syndrome Gastroenterology 71: A-6/899

    Google Scholar 

  206. Kramer HJ (1979) Humoral and hormonal factors in the pathogenesis of sodium retention in liver cirrhosis and the H.R.S. In: Bartoli E, Chiandussi L (eds) Hepatorenal syndrome. Piccin Medical Books, Padua, pp 311–343

    Google Scholar 

  207. Zipser R, Hoefs J, Speckart P, Zia P, Horton R (1977) Evidence for a critical role of prostaglandins in renin release, vascular reactivity and renal function in liver cirrhosis. Clin Res 25: 305 A

    Google Scholar 

  208. Debongnie JC, Pauls C, Fievez M, Wibin E (1971) Prospective evaluation of the diagnostic accuracy of liver ultrasonography. Gut 22: 130–135

    Article  Google Scholar 

  209. Lutz H (1976) Ultraschalldiagnostik in der Gastroenterologie. Dtsch Ärztebl 4: 175–181

    Google Scholar 

  210. Lutz H, Ehler R, Reichel L, Meyer P (1979) Stellenwert der Ultraschalldiagnostik bei Lebererkrankungen, Klinikarzt 8: 533–541

    Google Scholar 

  211. Rettenmaier G (1976) Sonographischer Oberbauchstatus. Internist 17: 549–564

    PubMed  CAS  Google Scholar 

  212. Strohm WD (1979) Ultraschalltomographie bei der Differenzierung parenchymatöser Lebererkrankungen. Z Gastroenterol 17: 663

    Google Scholar 

  213. Vogel H-M, Scherer K, Look D (1980) Comparative studies of laparoscopy, histology, and Gray-scale echotomography in diffuse diseases of the liver. Endoscopy 12: 166–174

    Article  PubMed  CAS  Google Scholar 

  214. Breddin K, Lechner K (1976) Blutgerinnung in der Gastroenterologie. Z Gastroenterol 14: 202–210

    Google Scholar 

  215. Damus PS, Wallace GA (1975) Immunologic measurement of antithrombin III heparin cofactor and alpha-2-macroglobulin in disseminated intravascular coagulation and hepatic failure coagulopathy. Thromb Res 6: 27–38

    Article  PubMed  CAS  Google Scholar 

  216. Duckert F (1973) Behaviour of antithrombin III in liver disease. Scand J Gastroenterol [Suppl 19] 8: 109–112

    Google Scholar 

  217. Heene DL (s. Ref. 1)

    Google Scholar 

  218. Liehr H, Grün M (1979) Funktionsstörungen des retikulo-endothelialen Systems (RES) In: Kühn HA, Wernze H (Hrsg) Klinische Hepatologie. Thieme, Stuttgart, S 3–151

    Google Scholar 

  219. Liehr H, Englisch G, Rasenack U (1980) Lactulose a drug with antiendotoxin effect. Hepatogastroenterol 27: 356–360

    CAS  Google Scholar 

  220. Mannucci L, Diaguardi N, Del Nimo E, Mannucci M (1973) Value of normotest and antithrombin III in the assessment of liver function. Scand J Gastroenterol [Suppl 19] 8: 103–107

    Google Scholar 

  221. Morawitz P (1905) Die Chemie der Blutgerinnung. Ergebn Physiologie 4: 407

    Google Scholar 

  222. Röka L (1977) Antithrombin. Schriftreihe Boehringer-Mannheim

    Google Scholar 

  223. Sautter T, Liehr H, Grün M, Brunswig D (1977) Die Behandlung der Endotoxinämie bei Leberzirrhose mit Polymyxin B. Verh Dtsch Ges Inn Med 83:1148–1151 —11. Schultze HE, Heremans JF (1966) Molecular biology of human proteins, vol 1. Elsevier Publ. Comp., Amsterdam London New York

    Google Scholar 

  224. Colombi A (1970) Early diagnosis of fatal hepatitis. Digestion 3: 129–145

    Article  PubMed  CAS  Google Scholar 

  225. Fischer M, Vogel G (1977) Extrakorporale Perfusion mit Pavianlebern zur Behandlung des Leberzerfallkomas. Dtsch Med Wochenschr 50: 1862

    Google Scholar 

  226. Hütteroth TH, Meyer zum Büschenfelde KH (1979) Behandlung des akuten Leberversagens. Dtsch Med Wochenschr 104: 1692–1694

    Article  PubMed  Google Scholar 

  227. Koff RS (1978) Acute viral hepatitis In: Harrison’s principles of internal medicine. McGraw Hill Book Company, New York, pp 379–383

    Google Scholar 

  228. Kommerell B (1978) Akute Hepatitis fulminante Verlaufsform. Diagnostik und prognostische Kriterien. In: Die entzündete Leber; zum IV. Hamburger Medizinischen Symposium am 1. und 2. Dezember 1978, S 41–47

    Google Scholar 

  229. Maier KP, Gerok W (1978) Therapie des akuten Leberversagens. Dtsch Med Wochenschr 103: 722–724

    Article  PubMed  CAS  Google Scholar 

  230. Oka K, Tanaka K (1979) Intravascular coagulation in autopsy cases with liver diseases. Thromb Haemostas 42: 564–570

    CAS  Google Scholar 

  231. Rake MO, Shilkin KB, Winch J, Flute PT, Lewis ML, Williams R (1971) Early and intensive therapy of intravascular coagulation in acute liver failure. Lancet 4: 1215–1218

    Article  Google Scholar 

  232. Ronneberger H, Hein D (1980) Antithrombin III effects on experimental liver necrosis. Abstr. 2nd Congr. of Toxicology, Brüssel

    Google Scholar 

  233. Vogel GE, Bottermann P, Kuhlencordt M, Fritsche H-M, Stemberger A, Blümel G, Fischer M, Schleicher P, Sommoggy St v (1979) Antithrombin III in der Behandlung von Gerinnungsstörungen beim akuten Leberversagen. Verh Dtsch Ges Inn Med 85: 477–480

    Google Scholar 

  234. Terblanche J, Northover JMA, Bornman P, Kahn D, Silber W, Barbezat GO, Sellars S, Campbell JAH, Saunders J (1979) A prospective controlled trial of sclerotherapy in the long term management of patients after esophageal variceal bleeding. Surg Gynecol Obstet 148: 323–333

    PubMed  CAS  Google Scholar 

  235. Clark AW, Westaby D, Silk DBA, Dawson JL, MacDuogall BRD, Mitchell KJ, Strunin L, Williams R (1980) Prospective controlled trial of injection sclerotherapy in patients with cirrhosis and recent variceal haemorrhage. Lancet 2: 552–554

    Article  PubMed  CAS  Google Scholar 

  236. Child CG, Turcotte JG (1964) Surgery and portal hypertension. In: Child CG (ed) The liver and portal hypertension. Saunders, Philadelphia, p 50

    Google Scholar 

  237. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R (1973) Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60: 646–649

    Article  PubMed  CAS  Google Scholar 

  238. Heymsfield SB, Fulenwider T, Nordlinger B, Barlow R, Sones P, Kutner M (1979) Accurate measurement of liver, kidney, and spleen volume and mass by computerized axial tomography. Ann Intern Med 90: 185–187

    Article  PubMed  CAS  Google Scholar 

  239. Bircher J, Paumgartner G, Cueni B, Herz R, Preisig R (1973) The significance of liver volume in patients with cirrhosis. The liver. Quantitative aspects of structure and function. Karger, Basel, pp 87–94

    Google Scholar 

  240. Amman R, Olsen R, Schersten T (1976) Survival after portocaval shunt. Who and how? Acta Med Scand 199: 167–173

    Article  Google Scholar 

  241. Colton Th (1974) Statistics in medicine. Little, Brown and Company, Boston

    Google Scholar 

  242. Creuzfeld W, Beck K (1966) Erhebungen über Ätiologie, Pathogenese, Therapieerfolg und Überlebenszeit an einem unausgewählten Krankengut von 560 Patienten mit Leberzirrhose. Dtsch Med Wochenschr 91: 682–688

    Article  Google Scholar 

  243. Curtler S, Ederer F (1958) Maximum utilization of the life table method in analyzing survival. J Chronic Dis 8: 699

    Article  Google Scholar 

  244. Frank H, Leodolzer I (1971) Leberzirrhose. Dtsch Med Wochenschr 32: 1291–1296

    Article  Google Scholar 

  245. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, McPherson K, Peto J, Smith PG (1976, 1977 ) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer 34: 585–612; 35: 1–39

    CAS  Google Scholar 

  246. Ruf-Bächtinger L (1967) Zur Prognose der Leberzirrhose. Schweiz Med Wochenschr 97: 74–78, 124–128

    Google Scholar 

  247. Ufer Ch, Dölle W, Martini GA (1966) Überlebensdauer und Prognose bei Kranken mit Leberkoma. Internist 1: 43–47

    Google Scholar 

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Authors and Affiliations

  1. Abt. für Gastroenterologie, Med. Univ.-Klinik, Freiburg, Deutschland

    J. Rasenack, J. Pausch & W. Gerok

  2. Med. Univ.-Klinik, Würzburg, Deutschland

    W. Riegel, J. Stepinski, W. H. Hörl, A. Heidland, G. Müller, H. Wernze, R. Katzfuß, M. Goerig, H. Liehr, F. Doht, E. Brugger, K. Feldmann & D. Brunswig

  3. Abt. für Gastroenterologie und Hepatologie, Zentrum Innere Medizin der Med. Hochschule, Hannover, Deutschland

    R. Müller, A. Feuerhake & H. Klein

  4. Städt. Krankenanstalten, Turin, Italy

    M. Rizzetto

  5. Abt. Innere Medizin und Poliklinik, Klinikum Charlottenburg, FU Berlin, Deutschland

    M. Manns & K. H. Meyer Zum Büschenfelde

  6. Inst. für klin. Pharmakologie der Univ. Bern, Med, Univ.-Klinik Würzburg und School of BiochemistryUniv. of Melbourne, Deutschland

    K. Weigand, H. Dryburg & G. Schreiber

  7. Abt. Gastroenterologie, Med. Univ.-Klinik, Heidelberg, Deutschland

    U. Gärtner

  8. Med. Kernklinik und Poliklinik, Univ.-Krankenhaus Eppendorf, Hamburg, Deutschland

    E. Windier

  9. Rdiovascular Research Inst, Univ. of California, San Francisco, Deutschland

    R. J. Havel

  10. Inst. für Klin. Pharmakologie Univ, Bern, Deutschland

    H. Wietholtz, M. Voegelin, J. Bircher & R. Preisig

  11. Stlé Products Technical Assistance Co. Ltd, La Tour-de-Peilz, Deutschland

    M. J. Arnaud

  12. Med. Univ.-Klinik, Freiburg, Deutschland

    W. Gerok, M. Rössle, R. Herz & W. Hiss

  13. Zentrum für Innere Medizin, Chirurgie und Radiologie der Univ, Freiburg, Deutschland

    W. Gerok, R. Herz, H. J. Halbfass, M. Rössle, K. Mathias & K. P. Maier

  14. Städt. Krankenhaus Schweinfurt und Med, Univ.-Klinik, Würzburg, Deutschland

    M. Grün, H. Heusler, R. Joeres & E. Richter

  15. Med. Univ.-Klinik Freiburg, Chirurg. Univ.-Klinik Hamburg und Chirurg. Univ.-Klinik, Tübingen, Deutschland

    W. Gerok, J. Schölmerich, C. Rodloff, T. Rogg, B. Kremer & K. Schmidt

  16. Med. Univ. -Klinik, Freiburg, Deutschland

    W. Gerok, S. Matern & H. Matern

  17. Med. Univ.-Klinik, Bonn, Deutschland

    O. Leiß & K. Bergmann

  18. Med. Univ.-Klinik, Heidelberg, Deutschland

    G. Middelhoff, B. Löser & A. Stiehl

  19. Univ. -Krankenhaus Hamburg-Eppendorf, Deutschland

    H. Greten

  20. Med. Univ.-Klinik, Tübingen, Deutschland

    P. A. Berg, E. Stechemesser, J. Strienz, H. Hoensch, W. Dölle, E. H. Egberts, C. Maier, H. Schomerus & R. Maulbetsch

  21. Med. Klinik, Deutschland

    J. C. Bode, P. Hanisch & F. Gloystein

  22. Fachbereich der Physik der Univ, Marburg, Deutschland

    W. Richter

  23. Kurklinik Föhrenkamp der BfA, Mölln, Deutschland

    H. Henning

  24. Med. Klinik der Univ, Marburg, Deutschland

    C. Bode

  25. Zentrum für Innere, Medizin, Deutschland

    G. Oehler & M. Knecht

  26. Inst. für klin, Chemie, Deutschland

    H. Bleyl

  27. Zentrum für Innere Medizin, Gießen, Deutschland

    K. Matthes

  28. Med. Klinik der Univ, Marburg, Deutschland

    J. C. Bode, C. Bode, V. Kugler & H. K. Dürr

  29. Med. Klinik II, Deutschland

    T. Sauerbruch & M. Weinzierl

  30. Radiolog. Klini, Deutschland

    B. Mayr

  31. Med Klinik II, Klinikum Großhadern der Univ, München, Deutschland

    M. Härlin, J. Eisenburg & G. Paumgartner

  32. II. Med. Klinik und Poliklinik, Deutschland

    G. E. Vogel, P. Bottermann, M. Clarmann, C. Komm & M. Kuhlencordt

  33. Inst. für Klin. Chemie und Pathobiochemie der TU München am Klinikum Rechts der Isar, Deutschland

    A. Oberdorfer, M. Waltenberg, J. Erckenbrecht, A. Sonnenberg, P. Peter & M. Wienbeck

  34. Med. Klinik D der Univ. Düsseldorf und Allgemeines Krankenhaus, Hagen, Deutschland

    W. E. Eickenbusch

  35. River Research Center, Albert Einstein College of Medicine, New York, USA

    W. G. Levine & A. W. Wolkoff

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  1. J. Rasenack
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  2. J. Pausch
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  7. A. Heidland
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  8. R. Müller
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  10. A. Feuerhake
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  11. H. Klein
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  12. M. Manns
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  13. K. H. Meyer Zum Büschenfelde
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  14. K. Weigand
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  19. R. J. Havel
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  20. H. Wietholtz
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  21. M. Voegelin
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  22. M. J. Arnaud
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  23. J. Bircher
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  24. R. Preisig
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  25. M. Rössle
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  26. R. Herz
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  27. W. Hiss
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  28. R. Herz
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K. Miehlke

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© 1981 Springer-Verlag Berlin Heidelberg

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Rasenack, J. et al. (1981). Hepatologie. In: Miehlke, K. (eds) Verhandlungen der Deutschen Gesellschaft für innere Medizin. Verhandlungen der Deutschen Gesellschaft für innere Medizin, vol 87. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-47092-9_16

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  • DOI: https://doi.org/10.1007/978-3-642-47092-9_16

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0327-6

  • Online ISBN: 978-3-642-47092-9

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