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DNA gene vaccination for HIV

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Gene Vaccination: Theory and Practice

Part of the book series: Principles and Practice ((PRINCIPLES))

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Abstract

The human immunodeficiency virus-1 (HIV-1) is a retrovirus which preferentially infects and kills CD4+ T cells and macrophages, ultimately resulting in immune system failure and multi-pathogen infections. Recent breakthroughs in combination therapy using three different anti-retroviral agents have generated optimism regarding the ability to control viral replication in vivo [46]. However, this therapeutic regimen is costly, and it is too early to tell whether this approach can eradicate established infection [26, 46]. The costs and the stringent administration regimen requirements of these pharmaceutical agents make it clear that these drugs will only be effectively utilized in a limited part of the world population. Therefore, to address the worldwide problem of HIV-1 infection, there remains a need for a prophylactic vaccination strategy designed to control the epidemic through mass immunization campaigns [115].

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Authors and Affiliations

  1. Department of Chemical Engineering, University of Pennsylvania, 505 Stellar-Chance, 422 Curie Blvd., Philadelphia, PA, 19104, USA

    Jong J. Kim

  2. Department of Pathology and Laboratory Medicine, University of Pennsylvania, 505 Stellar-Chance, 422 Curie Blvd., Philadelphia, PA, 19104, USA

    Jong J. Kim & David B. Weiner

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  1. Jong J. Kim
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  2. David B. Weiner
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Editors and Affiliations

  1. Department of Medicine, University of California, San Diego, 9500 Gilman Drive, 92093-0663, La Jolla, CA, USA

    Eyal Raz M.D. (Associate Professor) (Associate Professor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Kim, J.J., Weiner, D.B. (1998). DNA gene vaccination for HIV. In: Raz, E. (eds) Gene Vaccination: Theory and Practice. Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46867-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-46867-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46869-8

  • Online ISBN: 978-3-642-46867-4

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