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Genetic adjuvants for DNA immunization

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Gene Vaccination: Theory and Practice

Part of the book series: Principles and Practice ((PRINCIPLES))

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Abstract

The injection of naked plasmid DNA expression vectors into animal muscle or skin has been shown to be an effective means to stimulate cellular and humoral immunity against the expressed protein [36]. However, even though such DNA vaccines in some cases may be more effective than inactivated virus or subvirion vaccines in inducing anti-viral immunity [8, 12], the immune response that they elicit is often too weak or too late in developing to provide protective immunity [10, 23]. For this reason, investigators have attempted to enhance the efficacy of DNA vaccines by co-injecting plasmids encoding immune stimulatory cytokines, such as IL-2 and GM-CSF, along with plasmid encoding the antigen [17, 29, 35, 37].

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Author information

Authors and Affiliations

  1. UCSD Human Gene Therapy Program, Division of Hematology/Oncology, Department of Medicine, UCSD School of Medicine, La Jolla, CA, 92093-0663, USA

    Robert B. Mendoza & Thomas J. Kipps

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  1. Robert B. Mendoza
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  2. Thomas J. Kipps
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of California, San Diego, 9500 Gilman Drive, 92093-0663, La Jolla, CA, USA

    Eyal Raz M.D. (Associate Professor) (Associate Professor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Mendoza, R.B., Kipps, T.J. (1998). Genetic adjuvants for DNA immunization. In: Raz, E. (eds) Gene Vaccination: Theory and Practice. Principles and Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46867-4_4

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  • DOI: https://doi.org/10.1007/978-3-642-46867-4_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46869-8

  • Online ISBN: 978-3-642-46867-4

  • eBook Packages: Springer Book Archive

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