Abstract
Natural killer (NK) cell mediated cytotoxicity is affected by both triggering and inhibitory signals (see e.g., Gumperz and Parham 1995; Lanier and Philips 1996; Raulet 1996). In several models target cell major histocompatibility complex (MHC) class I molecules have been demonstrated to be able to turn off NK cells (Ljunggren and Kärre 1990; Kärre 1995) by delivering inhibitory signals to MHC class I binding receptors (Karlhofer et al. 1992; Yokoyama and Seaman 1993). The latter include members of the Ly-49 receptors in mouse and the killer-cell inhibitor receptors (KIR) in man (Gumperz and Parham 1995; Lanier and Philips 1996; Raulet 1996). While much attention has been focused on the role of MHC class I inhibition of NK cell mediated cytotoxicity in recent years, significantly less attention has been devoted to receptor-ligand interactions that may trigger cytotoxicity. This review discusses new insights into the ability of costimulatory molecules to trigger NK cell mediated cytotoxicity.
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© 1998 Springer-Verlag Berlin Heidelberg
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Chambers, B.J., Wilson, J.L., Salcedo, M., Markovic, K., Bejarano, M.T., Ljunggren, H.G. (1998). Triggering of Natural Killer Cell Mediated Cytotoxicity by Costimulatory Molecules. In: Kärre, K., Colonna, M. (eds) Specificity, Function, and Development of NK Cells. Current Topics in Microbiology and Immunology, vol 230. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46859-9_5
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DOI: https://doi.org/10.1007/978-3-642-46859-9_5
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