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Acute and Late Toxicity on Peripheral Nerves After Chemotherapy — A Review

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Book cover Late Sequelae in Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Peripheral neuropathy has long been recognized as a problem in cancer patients. The diagnosis of cancer itself is associated with peripherial neuro-pathy of different degrees in approximately 20%–40% of patients (Paul et al. 1978). Furthermore, damage to the nervous system occurs as a common complication of antineoplastic therapy. Neuro-toxicity may follow treatment with radiation ther-apy, chemotherapy, biological response modifiers, or combined modality therapy, with no portion of the nervous system being immune from potential damage. The peripheral nervous system represents a comment target for the toxic effects of many chemotherapeutic agents. For drugs like cisplatin and vincristine peripheral neurological toxicity may be the dose-limiting factor that prevents a more intensive use of these agents. A number of different cytotoxic drugs have been identified as a cause of peripheral neuropathy, out of which cisplatin and the vinca alkaloids are the most frequent (Forman 1990a, b; Casey et al. 1973; Roelofs et al. 1984).

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Authors and Affiliations

  1. Abteilung Hämatologie/Onkologie, Medizinische Hochschule, Zentrum für Innere Medizin und Dermatologie, Kon-stanty-Gutschow-Strasse 8, 30623, Hannover, Germany

    Carsten Bokemeyer Dr. & H.-J. Schmoll Prof., Dr.

  2. Universitätsklinikum Magdeburg, Leip-zigerStrasse 44, 39120, Magdeburg, Germany

    Bernd Frank Dr

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  1. Carsten Bokemeyer Dr.
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  2. H.-J. Schmoll Prof., Dr.
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  3. Bernd Frank Dr
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Editors and Affiliations

  1. Strahlentherapeutische Klinik, Martin-Luther-Universität Halle-Wittenberg, Dryanderstraße 4-7, 06097, Halle/Saale, Germany

    Jürgen Dunst

  2. Klinik und Poliklinik für Strahlentherapie, Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany

    Rolf Sauer

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© 1995 Springer-Verlag Berlin Heidelberg

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Bokemeyer, C., Schmoll, HJ., Frank, B. (1995). Acute and Late Toxicity on Peripheral Nerves After Chemotherapy — A Review. In: Dunst, J., Sauer, R. (eds) Late Sequelae in Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46794-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-46794-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46796-7

  • Online ISBN: 978-3-642-46794-3

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