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Dose-Time Considerations for Skeletal Growth Disturbances After Radiotherapy

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Late Sequelae in Oncology

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

The radiation-induced growth arrest of bones after radiotherapy in childhood is a side effect well known to pediatric oncologists. In 1903, Perthes described growth retardation which occurred after irradiation of the wings of 1 day old chicks and noted an influence of dose and fractionation. Later on, many case reports appeared regarding radiation-induced damage of growing bones after radiation therapy for tumors and for benign childhood diseases. A very detailed study was published by Dahl (1936), who irradiated 12-14 day old rats with doses of 0.8-40 Gy. The degree of growth arrest was found to be dependent on the dose and indirectly correlated with the age at the time of irradiation. Furthermore fractionation was found to produce a lesser degree of damage than signle dose irradiation.

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Authors and Affiliations

  1. Klinik und Poliklinik für Strahlentherapie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany

    Horst Alheit Dr.

Authors
  1. Horst Alheit Dr.
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Editors and Affiliations

  1. Strahlentherapeutische Klinik, Martin-Luther-Universität Halle-Wittenberg, Dryanderstraße 4-7, 06097, Halle/Saale, Germany

    Jürgen Dunst

  2. Klinik und Poliklinik für Strahlentherapie, Universität Erlangen-Nürnberg, Universitätsstraße 27, 91054, Erlangen, Germany

    Rolf Sauer

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© 1995 Springer-Verlag Berlin Heidelberg

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Alheit, H. (1995). Dose-Time Considerations for Skeletal Growth Disturbances After Radiotherapy. In: Dunst, J., Sauer, R. (eds) Late Sequelae in Oncology. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46794-3_31

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  • DOI: https://doi.org/10.1007/978-3-642-46794-3_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46796-7

  • Online ISBN: 978-3-642-46794-3

  • eBook Packages: Springer Book Archive

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