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Clinical Aspects of Familial Forms of Alzheimer’s Disease

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Genetic Research in Psychiatry

Abstract

Familial Alzheimer’s disease (FAD) has been recognized at least since Lua’s report in 1920. Since then over 100 families with FAD have been reported in different countries.1 Even though nongenetic cases may possibly occur, it is unlikely that the aggregation of affected in families can be explained by chance alone. Autosomal dominant inheritance with age-dependent penetrance has been suggested to explain this aggregation in most of these families. At least 70 reported families contain affected members in at least 3 generations, suggesting an autosomal dominant mode of inheritance in these families. The reports from the remaining families do not contain sufficient information to differentiate between a commonly occurring recessive gene, a dominant transmitted disorder, or multiplex clustering of a nongenetic trait. Analysis of pedigrees segregating a disease phenotype may suggest possible modes of transmission. In addition such pedigrees may allow detection of a unique feature which defines specific subtypes of the disease.

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Authors
  1. L. Amaducci
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  2. P. Forleo
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  3. P. Piersanti
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  4. S. Sorbi
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Editor information

Editors and Affiliations

  1. Hôpital Erasme, University Hospital of Brussels, Route de Lennik 808, B-1070, Bruxelles, Belgium

    Julien Mendlewicz

  2. University of Munich, Nussbaumstrasse 7, D-W-8000, München 2, Germany

    Hanns Hippius (Head of Dept. of Psychiatry) (Head of Dept. of Psychiatry)

  3. Dept. of Psychiatry, University of Munich, Nussbaumstrasse 7, D-W-8000, München 2, Germany

    Brigitta Bondy  & Manfred Ackenheil  & 

  4. Department of Chemical Pathology, Queen Charlotte’s Maternity Hospital, Goldhawk Road, W6 OXG, London, UK

    Merton Sandler

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© 1992 Springer-Verlag Berlin Heidelberg

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Amaducci, L., Forleo, P., Piersanti, P., Sorbi, S. (1992). Clinical Aspects of Familial Forms of Alzheimer’s Disease. In: Mendlewicz, J., Hippius, H., Bondy, B., Ackenheil, M., Sandler, M. (eds) Genetic Research in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46762-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-46762-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46764-6

  • Online ISBN: 978-3-642-46762-2

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