Abstract
Family, twin, and adoption studies suggest the involvement of genetic factors in manic-depressive illness (MDI) but the mode of inheritance remains elusive. The remarkable success with which the classical logarithm of odds (lod) score method has contributed to the localization of loci for numerous diseases has led many authors to apply this strategy to complex illnesses such as affective disorders. Most pertinent was the study conducted by Egeland et al. in 1987, which was based on an extended pedigree in order to minimize a possible genetic heterogeneity. These investigators reported a linkage between MDI and insulin (INS) and c-Harvey-ras-1 oncogene (HRAS) markers located within 11p15. But a recent reinvestigation of the Amish pedigree and the study of a set of non-Amish pedigrees call into question this initial finding (Kelsoe et al. 1989).
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Mallet, J. et al. (1992). Family Studies of Affective Disorders with 11p15.5 DNA Markers. In: Mendlewicz, J., Hippius, H., Bondy, B., Ackenheil, M., Sandler, M. (eds) Genetic Research in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46762-2_14
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DOI: https://doi.org/10.1007/978-3-642-46762-2_14
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