Abstract
With evidence from family, twin, and adoption studies, heredity appears to be a significant etiological factor in several neuropsychiatric disorders including schizophrenia (McGuffin 1988), bipolar affective disorder (Kidd and Weisman 1978), and Gilles de la Tourette’s syndrome (Pauls and Leckerman 1986). However, the mode of inheritance of these diseases is complex and does not follow simple mendelian expectations. In addition, the probable etiological heterogeneity of diseases such as schizophrenia complicates the analysis for linkage studies. Molecular biology has provided polymorphic DNA markers, which can be classified into two types. Nonspecific approaches utilize anonymous markers along the entire genome, the number of which strongly increases as the genome mapping becomes more detailed. This approach might be fruitful, but is a long and exacting task. On the other hand, if the underlying biological substrates for these diseases can be identified, then the gene(s) governing these substrates may constitute good candidate gene(s).
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References
Björklund A, Lindvall O (1984) Dopamine-containing systems in the CNS. In: Björklund A, Hökfelt T (eds) Classical transmitters in the CNS. Elsevier, Amsterdam, pp 55–122 (Handbook of chemical neuro-anatomy, vol 2 )
Bouthenet ML, Souil E, Martres MP, Sokoloff P, Giros B, Schwartz JC (1991) Localization of dopamine D, receptor RNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D, receptor mRNA. Brain Res (in press)
Bunzow JR, Van Tol HHM, Grandy DK, Albert P, Salon J, Christie McD, Machida CA, Neve A, Civelli O (1988) Cloning and expression of a rat D, dopamine receptor cDNA. Nature 336: 783–787
Carlsson A (1988) The current status of the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1: 179–186
Dal Toso R, Sommer B, Ewert M, Herb A, Pritchell DB, Bach A, Shivers BD, Seeburg PH (1989) The dopamine D, receptor: two molecular forms generated by alternative splicing. EMBO J 8: 4025–4034
Dearry A, Gingrich JA, Falardeau P, Fremeau RT, Bates MD, Caron MG (1990) Molecular cloning and expression of the gene for a human D, dopamine receptor. Nature 347: 72–76
Findlay J, Eliopoulous E (1990) Three-dimensional modelling of G protein-linked receptors. Trends Pharmacol Sci 11: 492–499
Fremeau RT, Duncan GE, Fornaretto MG, Dearry A, Gingrich JA, Brees GR, Caron MG (1991) Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission. Proc Natl Acad Sci USA 88: 3772–3776
Giros B, Sokoloff P, Martres MP, Riou JF, Emorine LJ, Schwartz JC (1989) Alternative splicing directs the expression of two D, dopamine receptor isoforms. Nature 342: 923–926
Giros B, Martres MP. Sokoloff P, Schwartz JC (1990) cDNA cloning of the human dopaminergic D3 receptor and chromosome identification. CR Acad Sci (Paris) 111:501–508
Giros B, Martres MP, Pilon C, Sokoloff P and Schwartz JC (1991) Shorter variants of the D. dopamine receptor produced through various patterns of alternative splicing. Biochem Biophys Res Commun 176: 1584–1592
Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277: 93–96
Kidd KK, Weisman MM (1978) Why do we not understand the genetics of affective disorders. In: Cole JJ, Schurtzberg AF, Frazier SH (eds) Depression: biology, psychodynamics and treatment. Plenum, New York, pp 107–121
Lannfelt L, Sokoloff P, Martres MP, Pilon C, Giros B and Schwartz JC (1991) The dopamine D, receptor gene and schizophrenia. Psychiatr Genet 2: 16
Le Coniat M, Sokoloff P, Hillion J, Martres MP, Giros B, Pilon P, Schwartz JC, Berger R (1991) Chromosomal localization of the human D, dopamine receptor gene. J Am Hum Genet (in press)
Martres MP, Bouthenet ML, Sales N, Sokoloff P and Schwartz JC (1985) Widespread distribution of brain dopamine receptors evidenced with’25I-iodosulpride, a highly selective ligand. Science 228: 752–755
Martres MP, Sokoloff P, Giros B, Schwartz JC (1991) Effects of dopaminergic transmission interruption on the Dz receptor isoforms in various cerebral tissues. J Neurochem (in press)
McGuffin P (1988) Genetics of schizophrenia. In: Beddington P, McGuffin P (eds) Schizophrenia: the major issues. Heinemann Medical, London, pp 107–126
Meador-Woodruff JH, Mansour A, Bunzow JR, Van Tol HHM, Watson SJ, Civelli O (1989) Distribution of D, dopamine receptor mRNA in rat brain. Proc Natl Acad Sci USA 86:7625–7628
Monsma FJ, Mahan LC, McVittie LD, Gerfen CR, Sibley DR (1990) Molecular cloning and expression of a D, dopamine receptor linked to adenylyl cyclase activation. Proc Natl Acad Sci USA 87: 6723–6727
Murphy DL, Brodie HKH, Goodwin FK (1971) Regular indication of hypomania by L-dopa in “bipolar” manic-depression patients. Nature 229: 135–136
Pauls DL, Leckerman JF (1986) The inheritance of Gilles de la Tourette syndrome and associated behavior. N Engl J Med 316: 993–997
Schwartz JC, Delandre M, Martres MP, Sokoloff P, Protais P, Vasse M, Costentin J, Laibe P, Wermuth CG, Gulat C, Lafitte A (1984) Biochemical and behavioral identification of discriminant benzamide derivatives: new tools to differentiate subclasses of dopamine receptors. In: Usdin E, Carlsson A. Dahlstrom A, Engel J (eds) Catecholamines: neuropharmacology and central nervous system. Theoretical aspects. Liss, New York, pp 59–72 (Neurology and neurobiology, vol 8B )
Sokoloff P, Giros B, Martres MP, Bouthenet ML, Schwartz JC (1990) Molecular cloning and characterization of a novel dopamine receptor ( D) as a target for neuroleptics. Nature 347: 146–151
Spano PF, Govoni S, Trabucchi M (1978) Studies on the pharmacological properties of dopamine receptors in various areas of the central nervous system. Adv Biochem Psychopharmacol 19: 155–165
Strader DC, Sigal SI, Dixon AFR (1989) Mapping of functional domains of the 13-adrenergic receptor. Am J Respir Cell Mol Biol 1: 81–86
Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang Y, Israel Y, Seeman P, O’Dowd BF (1990) Human dopamine D, receptor encoded by an intronless gene on chromosome 5. Nature 347: 80–83
Sunahara RK, Guan HC, O’Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Turchia J, Van Tol HHM, Niznik HB (1991) Cloning of the gene for a human dopamine Ds receptor with higher affinity for dopamine than D. Nature 350: 614–619
Svensson K, Johansson AM, Magnusson T, Carlsson A (1986) (+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol 334: 234–245
Van Tol HHM, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991) Cloning of the gene for a human dopamine D, receptor with high affinity for the antipsychotic clozapine. Nature 350: 610–614
Wolf ME, Roth RH (1987) Dopamine autoreceptors. In: Creese I, Fraser CM (eds) Dopamine receptors, vol 8. Liss, New York, pp 45–96
Zhou QZ, Grandy DK. Thambi L, Kushner JA, Van Tol HHM, Cone R, Pribnow D, Salon J. Bunzow JR, Livelli O (1990) Cloning and expression of human and rat D dopamine receptors. Nature 347:76–80
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Sokoloff, P., Lannfelt, L., Martres, M.P., Giros, B., Bouthenet, M.L., Schwartz, J.C. (1992). The D3 Dopamine Receptor Gene as a Candidate Gene for Genetic Linkage Studies. In: Mendlewicz, J., Hippius, H., Bondy, B., Ackenheil, M., Sandler, M. (eds) Genetic Research in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46762-2_10
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DOI: https://doi.org/10.1007/978-3-642-46762-2_10
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