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Involvement of Protein Kinase C in the Regulation of Nerve Growth Factor Synthesis: A Possible Cause of Impaired Trophic Supply in Alzheimer’s Disease?

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Growth Factors and Alzheimer’s Disease

Part of the book series: Research and Perspectives in Alzheimer’s Disease ((ALZHEIMER))

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Summary

It is of interest to characterize the regulatory mechanisms which control the synthesis of nerve growth factor (NGF) in order to design pharmacological procedures that might modulate the production of neurotrophic factor in vivo. This approach may be of valuable help in minimizing the deleterious effects of neurodegenerative diseases such as Alzheimer’s disease, which may affect NGF-responsive neurons.

Experiments performed with a line of mouse fibroblast-like cells demonstrated that serum increases the level of expression of NGF gene. The effect of serum on the NGF mRNA pool may be prevented by inhibitors of protein kinase activities, such as compound K 252a. This suggests that a protein phosphorylation step is involved in the up-regulation of NGF synthesis. The effect of serum can be mimicked both in fibroblasts and primary cultures of glial cells by the protein kinase C activator 12-O-tetradecanoyl-phorbol-13-acetate (TPA). This mechanism may be altered in neuropathological disorders such as Alzheimer’s disease or diabetes-associated peripheral neuropathy, where impaired or decreased protein kinase C activity is thought to take place.

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Authors
  1. P. Brachet
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  2. R. Houlgatte
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  3. I. Neveu
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  4. D. MacGrogan
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  5. D. Wion
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Editor information

Editors and Affiliations

  1. Andrus Gerontology Center, University of Southern California, 90089, Los Angeles, CA, USA

    Franz Hefti Ph. D.

  2. INSERM U 298, Centre Hospitalier Régional et Universitaire, F-49033, Angers Cedex, France

    Philippe Brachet Ph. D.

  3. Département de Neurophysiologie et de Biologie des Comportements, Centre de Neurochimie du C.N.R.S., 12 rue Goethe, F-67000, Strasbourg, France

    Bruno Will Ph. D.

  4. Fondation IPSEN pour la Recherche Thérapeutique, 30, rue Cambronne, F-75737, Paris Cedex, France

    Yves Christen Ph. D.

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© 1991 Springer-Verlag Berlin Heidelberg

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Brachet, P., Houlgatte, R., Neveu, I., MacGrogan, D., Wion, D. (1991). Involvement of Protein Kinase C in the Regulation of Nerve Growth Factor Synthesis: A Possible Cause of Impaired Trophic Supply in Alzheimer’s Disease?. In: Hefti, F., Brachet, P., Will, B., Christen, Y. (eds) Growth Factors and Alzheimer’s Disease. Research and Perspectives in Alzheimer’s Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46722-6_7

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  • DOI: https://doi.org/10.1007/978-3-642-46722-6_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46724-0

  • Online ISBN: 978-3-642-46722-6

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