Abstract
The aim of the present investigation was an assessment of toxic effects of ozone on primary cultures of human lung fibroblasts. It has been performed in order to complement the extensive published knowledge (footnote 1) about ozone-induced responses and mortalities of human tumour cell lines, and alveolar macrophages. Previous studies on cultivated lung fibroblasts have been performed using material from rodents (e.g. BASSETT et al., 1988), but reports on human lung fibroblasts are brief and scarce (e.g. BRAUNSCHWEIGER and SMITH, 1980). Fibroblasts constitute approximately 75% of interstitial lung tissue. By synthesizing collagen, and collagenase, fibroblasts are prominent effector cells in pathological processes leading to lung fibrosis, which can be caused by various agents, including ozone. In view of the high diffusion ability of this gas, it can be assumed that interstitial lung cells are affected by ozone in vivo.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bassett DJP, Bowen-Kelly E, Brewster EL, Elbon CL, Reichenbough SS, Bunton T, Kerr JS (1988) A reversible model of acute lung injury based on ozone exposure. Lung 166: 355–369.
Braunschweiger WR and Smith JR (1980) Sensitivity of human diploid cells to low concentrations of ozone.In Vitro16:204.
Ebert W, Mayer D, Vogt-Moykopf I (1988) Schädigung kultivierter Lungenzellen durch Inhalationsnoxen. Kernforschungszentrum KA GmbH, KfK-Pef 35, Vol. 2: 411–421.
Mayer D, Ebert W (1989) Schädigung humaner Lungenfibroblasten durch Ozon. Kernforschungszentrum KA GmbH, KfK-Pef 50 Vol. 2: 423–433.
Mollenhauer J and Bayreuther K (1986) Donor-age-related changes in the morphology, growth potential, and collagen biosynthesis in rat fibroblast subpopulations in vitro. Differentiation, 32: 165–172.
Phipps RP, Penney DP, Keng P, Quill H, Paxhia A, Derdak S, Felch ME (1989) Characterization of two major populations of lung fibroblasts: distinguishing morphology and discordant display of Thy 1 and class II MHC. Am J Respir Cell Mol Biol 1: 65–74.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Mayer, D., Ebert, W. (1990). Responses of Human Lung Fibroblasts to Ozone. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46712-7_24
Download citation
DOI: https://doi.org/10.1007/978-3-642-46712-7_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-46714-1
Online ISBN: 978-3-642-46712-7
eBook Packages: Springer Book Archive