Skip to main content

Lead(II) Interferes with the Repair and Processing of UV-Induced DNA Damage

  • Conference paper
Environmental Hygiene II

Abstract

Inorganic lead compounds are classified as possibly carcinogenic to humans (International Agency for Research on Cancer, IARC, 1987). Even though the data from epidemiological studies of lead-exposed workers with respect to carcinogenicity are still inadequate, lead has been shown to cause renal tumors and to be cocarcinogenic in experimental animals (reviewed by Swierenga et al., 1987). Regarding in-vitro tests, incorsistent results have been reported about the clastogenicity of inorganic lead compounds (Forni et al., 1980; Gebhart and Rossman, 1989). In a previous report, lead ions were shown to enhance the number of mutants at the HPRT-locus after long-term exposure of V79 cells. However, no direct DNA-damage like strand breaks or DNA-protein crossLinks were detected (Zelikoff et al., 1988). For that reason, we investigated Whether the genotoxicity is rather due to indirect effects like an interference with DNA repair processes, by applying UV as a standard mutagen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Charp PA, Regan JD (1985) Inhibition of DNA repair by trifluoperanzine. Biochim. Biophys. Acta 824: 34–39

    Google Scholar 

  • Cook PR, Brazell IA (1976) Detection and repair of single-strand breaks in nuclear DNA. Nature 263: 679–682

    Article  PubMed  CAS  Google Scholar 

  • Forni A, Sciame A, Bertazzi BA Alessio L (1980) Chromosome and biochemical studies in women occupationally exposed to lead. Arch. Environ. Health 35: 139–146

    Google Scholar 

  • Frenkel GD, Middleton C (1987) Effects of lead acetate on DNA and RNA synthesis by intact HeLa cells, isolated nuclei and purified polymerases. Biochem. Pharmacol. 36: 265–268

    Google Scholar 

  • Frenkel GD, Middleton C (1987) Effects of lead acetate on DNA and RNA synthesis by intact HeLa cells, isolated nuclei and purified polymerases. Biochem. Pharmacol. 36: 265–268

    Google Scholar 

  • Hartwig A, Beyersmann D (1989) Enhancement of UV-induced mutagenesis and sister-chromatid exchanges by nickel ions in V79 cells: evidence for inhibition of DNA repair. Mutation Res. 217: 65–73

    PubMed  CAS  Google Scholar 

  • IARC (1987) Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Supplement 7, IARC, Lyon, p 230

    Google Scholar 

  • Popenoe EA, Schmaeler MA (1979) Interaction of human polymerase p with ions of copper, lead, and cadmium. Arch. Biochem. Biophys. 196: 109–120

    Google Scholar 

  • Swierenga SHH, Gilman JPW, McLean JR (1987) Cancer risk from inorganics. Cancer and Metastasis Reviews 6: 113–154

    Article  PubMed  CAS  Google Scholar 

  • Yew F-H, Johnson RT (1979) Ultraviolet-induced DNA excision repair in human B and T lymphocytes, II. Effects of inhibitors and DNA precursors. Biochim. Biophys. Acta 562: 240–251

    Google Scholar 

  • Zelikoff JT, Li JH, Hartwig A, Wang XW, Costa M, Rossman TG (1988) Genetic toxicology of lead compounds. Carcinogenesis 9: 1727–1732

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Hartwig, A., Schlepegrell, R., Beyersmann, D. (1990). Lead(II) Interferes with the Repair and Processing of UV-Induced DNA Damage. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46712-7_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-46712-7_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46714-1

  • Online ISBN: 978-3-642-46712-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics