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Part of the book series: Lecture Notes in Biomathematics ((LNBM,volume 81))

Abstract

Mathematical models of the transmission of the AIDS virus can help us better understand the spread of the AIDS epidemic and prepare for the future. Model explorations can indicate which factors the epidemic is most sensitive to and provide guidance in designing interventions, educational programs and social behavior studies. We explore the sensitivity of a transmission model to different social mixing patterns. This model continuously distributes a homosexual community according to sexual partner change rates and can account for infectivity and conversion times that vary with time since infection. An acceptance function determines which partners are acceptable to an individual and defines the mixing between groups with different partner change rates. We find that if people only select partners with very similar behavior the epidemic grows much slower than if they are not as discriminating. Therefore, understanding social mixing patterns may be one of the most urgent tasks if we are to anticipate the future. We also find that the epidemic is sensitive to variable infectivity and conversion times.

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References

  • Anderson, R. M., May, R. M., Medley, G. F., and Johnson, A. 1986. A Preliminary Study of the Transmission Dynamics of the Human Immunodeficiency Virus (HIV), the Causative Agent of AIDS. IMA J. Math. Appt. Med. Biol. 3, 229–263.

    Article  MathSciNet  MATH  Google Scholar 

  • Auerbach, D. M., Darrow, W. W., Jaffe, H. W., and Curran, J. W. 1984. Cluster of Cases of the Acquired Immune Deficiency Syndrome. Patients Linked by Sexual Contact. Am. J. Med. 76, 487–492.

    Article  Google Scholar 

  • Colgate, S. A., Stanley, E. A., Hyman, J. M., Layne, S. P., and Qualls, C. 1988. A Behavior Based Model of the Initial Growth of AIDS in the United States. Los Alamos National Laboratory report.

    Google Scholar 

  • Darrow, W. W., Echenberg, D. F., and Jaffe, H. W. 1987. Risk Factors for Human Immunodeficiency Virus Infections in Homosexual Men. AJPH 77, 479–483.

    Article  Google Scholar 

  • Dietz, K. 1987. The Dynamics of Spread of HIV Infection in the Heterosexual Population unpublished report.

    Google Scholar 

  • Dietz, K. 1988. On the Transmission Dynamics of HIV. Proceedings of the 1987 CNLS Workshop on Nonlinearity in Medicine and Biology, Math. Bio. 90, 397–414.

    Article  MathSciNet  MATH  Google Scholar 

  • Fischi, M. A., Dickinson, G. M., Scott, G. B., Klimas, N., Fletcher, M. A., and Parks, W. 1987. Evaluation of Heterosexual Partners, Children, and Household Contacts of Adults with AIDS. JAMA 257, 640–644.

    Article  Google Scholar 

  • Francis, D. P., Feorino, P. M., Broderson, J. R., McClure, H. M., Getchell, J. P., McGrath, C. R., Swenson, B., McDougal, J. S., Palmer, E. L., Harrison, A. K., Barre-Sinoussi, F., Chermann, J.-C., Montagnier, L., Curran, J. W., Cabradilla, C. D., and Kalyanaraman, V. S. 1984. Infection of Chimpanzees with Lymphadenopathy-associated Virus. Lancet 1276–1277.

    Google Scholar 

  • Goedert, J. J., Biggar, R. J., and Winn, D. M. 1984. Determinants of Retrovirus (HTLV-III) Antibody and Immunodeficiency Conditions in Homosexual Men. Lancet 711–716.

    Google Scholar 

  • Grant, R., Wiley, J., and Winklestein, W. 1987. The Infectivity of the Human Immunodeficiency Virus: Estimates from a Prospective Study of a Cohort of Homosexual Men. J. Inf. Dis. 156, 189–193.

    Article  Google Scholar 

  • Hardy, A. M., Starcher, E. T., Morgan, W. M., Druker, J., Kristal, A., Day, J., Kelly, C., Ewing, E., and Curran, J. 1987. Review of Death Certificates to Assess Completeness of AIDS Case Reporting. Pub. Hlth. Rep. 102, 386–391.

    Google Scholar 

  • Hethcote, H. W. and Yorke, F. A. 1984. Gonorrhea: Transmission Dynamics and Control. Lecture Notes in Biomathematics 56, 1–105.

    MathSciNet  Google Scholar 

  • Hyman, J. M., Qualls, C. R., and Stanley, E. A. (in preparation). Analysis of CDC AIDS Data. Los Alamos National Laboratory report.

    Google Scholar 

  • Hyman, J. M. and Stanley, E. A. 1988. Using Mathematical Models to Understand the AIDS Epidemic. Mathematical Biosciences 90, 415–474.

    Article  MathSciNet  MATH  Google Scholar 

  • Jaquez, J., Koopman, J., Simon, C., Sattenspiel, L., and Perry, T. 1988. Modeling and Analyzing HIV Transmission: The Effect of Contact Patterns. Mathematical Biosciences 92, 119–199.

    Article  MathSciNet  Google Scholar 

  • Joseph, J. G., Montgomery, S., Kessler, R. C., Ostrow, D. G., Emmons, C.A., and Phair, J. P. Two-Year Longitudinal Study of Behavioral Risk Reduction in a Cohort of Homosexual Men. Presented June 1, 1987 at the I II International Conference on AIDS in Washington, DC.

    Google Scholar 

  • Kingsley, L. A., Kaslow, R., Rinaldo, C. R., Jr., Detre, K., Odaka, N., Van Raden, M., Detels, R., Polk, B. F., Chmiel, J., Kelsey, S. F., Ostrow, D., and Visscher, B. 1987. Risk Factors for Seroconversion to Human Immunodeficiency Virus Among Male Homosexuals. Lancet, 345–349.

    Google Scholar 

  • Lange, J.M.A., Paul, D. A., Huisman, H. G., de Wolf, F., van der Berg, H., Coutinho, R., Danner, S. A., van der Noordaa, J., and Goudsmit, J. 1986. Persistent HIV Antigenemia and Decline of HIV Core Antibodies Associated with Transition to AIDS. Br. Med. J. 293, 1459–1462.

    Article  Google Scholar 

  • May, R. M. and Anderson, R. M. 1987. Transmission Dynamics of HIV Infection. Nature 326, 137–142.

    Article  Google Scholar 

  • Medley, G. F., Anderson, R. M., Cox, D. R., and Billard, L. 1987. Incubation Period of AIDS in Patients Infected via Blood Transfusion. Nature 238, 719–721.

    Article  Google Scholar 

  • Padian, N., Wiley, J., and Winkelstein, W. Male to Female Transmission of Human Immunodeficiency Virus: Current Results, Infectivity Rates, and San Francisco Population Seroprevalence Estimates. Presented June 4, 1987, at the III International Conference on AIDS in Washington, DC.

    Google Scholar 

  • Peterman, T. A., Stoneburner, R. L., Allen, J. R. Jaffe, H. W., and Curran, J. 1988. Risk of Human Immunodeficiency Virus Transmission from Heterosexual Adults with Transfusion-Associated Infections. JAMA, 259, 55–58.

    Article  Google Scholar 

  • Sattenspiel, L. 1987. Population Structure and the Spread of Disease. Human Biology 59.

    Google Scholar 

  • Sattenspiel, L. and Simon, C. 1988. The Spread and Persistence of Infectious Diseases in Structured Populations. Proceedings of the 1987 CNLS Workshop on Nonlinearity in Medicine and Biology, Math. Bio. 90, 341–366.

    Article  MathSciNet  MATH  Google Scholar 

  • Stigum, H., Groennesby, J. K., Magnus, P., Sundet, J. M., and Bakketeig, L. S. 1988. The Effect of Selective Partner Choice on the Spread of HIV. Presented at the Conference on The Global Impact of AIDS, London.

    Google Scholar 

  • Sulahuddin, S. Z., Markham, P. D., Redfield, R. R., Essex, M., Groopman, J. E., Sarngadharan, M. G., McLane, M. F., Sliski, A., and Gallo, R. C. 1984. HTLV-III in Symptom-Free Seronegative Persons. Lancet, 1418–1420.

    Google Scholar 

  • Sundet, J., Kralem, I., Magnus, P., and Bakketeeig, L. 1988. Prevalence of Risk Prone Sexual Behavior in the General Population of Norway. Presented at the Conference on The Global Impact of AIDS, London.

    Google Scholar 

  • Winklestein, W., Lyman, D. M., Padian, N. S., Grant, R., Samuel, M., Wiley, J. A., Anderson, R. E., Lang, W., Riggs, J., and Levy, J. A. 1987. Sexual Practices and Risk of Infection by the Human Immunodeficiency Virus. JAMA 257, 321–325.

    Article  Google Scholar 

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© 1989 Springer-Verlag Berlin Heidelberg

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Hyman, J.M., Stanley, E.A. (1989). The Effect of Social Mixing Patterns on the Spread of AIDS. In: Castillo-Chavez, C., Levin, S.A., Shoemaker, C.A. (eds) Mathematical Approaches to Problems in Resource Management and Epidemiology. Lecture Notes in Biomathematics, vol 81. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46693-9_15

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  • DOI: https://doi.org/10.1007/978-3-642-46693-9_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-51820-4

  • Online ISBN: 978-3-642-46693-9

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