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Opioid Receptors and Ion Channels

  • Chapter
Neurobiology of Opioids

Abstract

At least three basic kinds of membrane receptor for transmitters and hormones can now be distinguished. The first type incorporates an ion channel (e.g., nicotinic acetylcholine receptor, γ-aminobutyric acidA receptor, 5-hydroxytryptamine3 receptor); agonist binding greatly increases the probability of channel opening (Fig. 1A). The second kind has an internal domain which binds guanosine 5’-triphosphate (GTP) binding protein (G-protein); agonist binding results in a much increased rate of synthesis of activated G-protein, which then interacts with different cellular effectors (Fig. 1B). The third class itself has enzyme activity on the internal domain, which is altered by agonist binding to an external domain (e.g., insulin and atrial naturietic factor receptors).

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Authors
  1. R. A. North
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Editors and Affiliations

  1. Department of Neuroendocrinology, Max Planck Institute for Psychiatry, Kraepelinstraße 2, D-8000, München 40, Germany

    Osborne F. X. Almeida

  2. Department of Neuropharmacology, Max Planck Institute for Psychiatry, D-8033, Martinsried, Germany

    Toni S. Shippenberg

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© 1991 Springer-Verlag Berlin Heidelberg

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North, R.A. (1991). Opioid Receptors and Ion Channels. In: Almeida, O.F.X., Shippenberg, T.S. (eds) Neurobiology of Opioids. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46660-1_8

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  • DOI: https://doi.org/10.1007/978-3-642-46660-1_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-46662-5

  • Online ISBN: 978-3-642-46660-1

  • eBook Packages: Springer Book Archive

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