Abstract
The inventory of neurotransmitter systems in different dementias is expanding rapidly. Most attention has been focused on the degenerative dementias, particularly Alzheimer’s disease (AD) and related disorders such as Parkinson’s disease (PD) (Whitehouse et al. 1985; Price et al. 1986). In this paper, we will review some of the neurochemical changes that have been reported in AD, focusing particularly on alterations in the cholinergic and bioaminergic systems. We will then discuss several approaches that are likely to improve our understanding of the neurochemical basis of dementia and behavioral symptoms and outline some strategies to better relate neurochemical studies to molecular biology and clinical investigations.
Keywords
- Alzheimer Disease
- Basal Forebrain
- Corticotropin Release Factor
- Progressive Supranuclear Palsy
- Neurochemical Change
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 1989 Springer-Verlag Berlin Heidelberg
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Whitehouse, P.J., Unnerstall, J.R., Tabaton, M., Lanska, D.J. (1989). Neurochemistry of Dementia: Clinical Pathological Relationships. In: Bergener, M., Reisberg, B. (eds) Diagnosis and Treatment of Senile Dementia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46658-8_6
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DOI: https://doi.org/10.1007/978-3-642-46658-8_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-50800-7
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