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The Molecular Basis of Cerebral Amyloidosis in Alzheimer’s Disease and the Unconventional Virus Diseases

  • C. L. Masters
  • R. Martins
  • G. Simms
  • B. Rumble
  • S. Fuller
  • L. Hutchinson
  • J. Beer
  • C. Hilbich
  • T. Dyrks
  • P. Fischer
  • A. Weidemann
  • U. Monning
  • G. Multhaup
  • M. Cramer
  • J. M. Salbaum
  • S. Wehr
  • K. Beyreuther
Conference paper
Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Summary

The major protein subunit of the amyloid fibril in Alzheimer’s disease is a small molecule of 42 residues (termed A4). It is derived from a larger precursor (PreA4), the gene for which is located on chromosome 21, in close proximity to the region involved in Down’s syndrome. The predicted structure of PreA4 suggests that it is an integral membrane glycoprotein. Knowledge of the mechanisms by which PreA4 is degraded to A4 may contribute to a better understanding of the cause of Alzheimer’s disease. Similarly, the amyloid fibril in the unconventional virus diseases is composed of the PrP molecule, which in turn is derived from a neuronal membrane glycoprotein. An understanding of the process by which the PrP molecule is converted into an amyloidogenic molecule may shed some light on the nature of the infectious unit.

Keywords

Down Syndrome Amyloid Fibril Paired Helical Filament Paired Helical Filament Cerebral Amyloidosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • C. L. Masters
  • R. Martins
  • G. Simms
  • B. Rumble
  • S. Fuller
  • L. Hutchinson
  • J. Beer
  • C. Hilbich
  • T. Dyrks
  • P. Fischer
  • A. Weidemann
  • U. Monning
  • G. Multhaup
  • M. Cramer
  • J. M. Salbaum
  • S. Wehr
  • K. Beyreuther

There are no affiliations available

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